The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol
Abstract Background Age-related musculoskeletal diseases are becoming increasingly burdensome in terms of both individual quality of life and medical cost. We intended to establish a large population-based cohort study to determine environmental, lifestyle, and genetic risk factors of musculoskeleta...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Komiyama Printing Co. Ltd
2018-06-01
|
| Series: | Environmental Health and Preventive Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12199-018-0715-2 |
| _version_ | 1811343232666173440 |
|---|---|
| author | Kazutoshi Nakamura Ribeka Takachi Kaori Kitamura Toshiko Saito Ryosaku Kobayashi Rieko Oshiki Yumi Watanabe Keiko Kabasawa Akemi Takahashi Shoichiro Tsugane Masayuki Iki Ayako Sasaki Osamu Yamazaki |
| author_facet | Kazutoshi Nakamura Ribeka Takachi Kaori Kitamura Toshiko Saito Ryosaku Kobayashi Rieko Oshiki Yumi Watanabe Keiko Kabasawa Akemi Takahashi Shoichiro Tsugane Masayuki Iki Ayako Sasaki Osamu Yamazaki |
| author_sort | Kazutoshi Nakamura |
| collection | DOAJ |
| description | Abstract Background Age-related musculoskeletal diseases are becoming increasingly burdensome in terms of both individual quality of life and medical cost. We intended to establish a large population-based cohort study to determine environmental, lifestyle, and genetic risk factors of musculoskeletal and other age-related diseases, and to clarify the association between vitamin D status and such diseases. Methods We targeted 34,802 residents aged 40–74 years living in areas of northern Niigata Prefecture, including Sekikawa Village, Awashimaura Village, and Murakami City (Murakami region). The baseline questionnaire survey, conducted between 2011 and 2013, queried respondents on their lifestyle and environmental factors (predictors), and self-reported outcomes. Plasma 25-hydroxyvitamin D (25[OH]D) concentration, an indicator of vitamin D status, was determined with the Liaison® 25OH Vitamin D Total Assay. The primary outcome of this study was osteoporotic fracture; other outcomes included age-related diseases including knee osteoarthritis, perception of chronic pain, dementia, and long-term care insurance use. Mean ages of men and women were 59.2 (SD = 9.3, N = 6907) and 59.0 (SD = 9.3, N = 7457) years, respectively. From the blood samples provided by 3710 men and 4787 women, mean 25(OH)D concentrations were 56.5 (SD = 18.4) nmol/L (22.6 ng/mL) and 45.4 (SD = 16.5) nmol/L (18.2 ng/mL), respectively. Discussion Follow-up surveys are planned every 5 years for 15 years, and incident cases of our targeted diseases will be followed at hospitals and clinics in and nearby the cohort area. We anticipate that we will be able to clarify the association between vitamin D status and multiple disease outcomes in a Japanese population. |
| first_indexed | 2024-04-13T19:26:10Z |
| format | Article |
| id | doaj.art-d42204134c8d46b18ef82033ef7626d7 |
| institution | Directory Open Access Journal |
| issn | 1342-078X 1347-4715 |
| language | English |
| last_indexed | 2024-04-13T19:26:10Z |
| publishDate | 2018-06-01 |
| publisher | Komiyama Printing Co. Ltd |
| record_format | Article |
| series | Environmental Health and Preventive Medicine |
| spelling | doaj.art-d42204134c8d46b18ef82033ef7626d72022-12-22T02:33:22ZengKomiyama Printing Co. LtdEnvironmental Health and Preventive Medicine1342-078X1347-47152018-06-012311810.1186/s12199-018-0715-2The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocolKazutoshi Nakamura0Ribeka Takachi1Kaori Kitamura2Toshiko Saito3Ryosaku Kobayashi4Rieko Oshiki5Yumi Watanabe6Keiko Kabasawa7Akemi Takahashi8Shoichiro Tsugane9Masayuki Iki10Ayako Sasaki11Osamu Yamazaki12Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental SciencesDivision of Preventive Medicine, Niigata University Graduate School of Medical and Dental SciencesDivision of Preventive Medicine, Niigata University Graduate School of Medical and Dental SciencesDepartment of Health and Nutrition, Niigata University of Health and WelfareDepartment of Physical Therapy, Niigata University of Health and WelfareDepartment of Physical Therapy, Niigata University of Health and WelfareDivision of Preventive Medicine, Niigata University Graduate School of Medical and Dental SciencesDepartment of Health Promotion Medicine, Niigata University Graduate School of Medical and Dental SciencesDepartment of Rehabilitation, Niigata University of RehabilitationCenter for Public Health Sciences, National Cancer CenterDepartment of Public Health, Kindai University Faculty of MedicineMurakami Public Health CenterNiigata Prefectural OfficeAbstract Background Age-related musculoskeletal diseases are becoming increasingly burdensome in terms of both individual quality of life and medical cost. We intended to establish a large population-based cohort study to determine environmental, lifestyle, and genetic risk factors of musculoskeletal and other age-related diseases, and to clarify the association between vitamin D status and such diseases. Methods We targeted 34,802 residents aged 40–74 years living in areas of northern Niigata Prefecture, including Sekikawa Village, Awashimaura Village, and Murakami City (Murakami region). The baseline questionnaire survey, conducted between 2011 and 2013, queried respondents on their lifestyle and environmental factors (predictors), and self-reported outcomes. Plasma 25-hydroxyvitamin D (25[OH]D) concentration, an indicator of vitamin D status, was determined with the Liaison® 25OH Vitamin D Total Assay. The primary outcome of this study was osteoporotic fracture; other outcomes included age-related diseases including knee osteoarthritis, perception of chronic pain, dementia, and long-term care insurance use. Mean ages of men and women were 59.2 (SD = 9.3, N = 6907) and 59.0 (SD = 9.3, N = 7457) years, respectively. From the blood samples provided by 3710 men and 4787 women, mean 25(OH)D concentrations were 56.5 (SD = 18.4) nmol/L (22.6 ng/mL) and 45.4 (SD = 16.5) nmol/L (18.2 ng/mL), respectively. Discussion Follow-up surveys are planned every 5 years for 15 years, and incident cases of our targeted diseases will be followed at hospitals and clinics in and nearby the cohort area. We anticipate that we will be able to clarify the association between vitamin D status and multiple disease outcomes in a Japanese population.http://link.springer.com/article/10.1186/s12199-018-0715-2Cohort studiesDementiaMusculoskeletal diseasesOsteoporotic fracturesVitamin D |
| spellingShingle | Kazutoshi Nakamura Ribeka Takachi Kaori Kitamura Toshiko Saito Ryosaku Kobayashi Rieko Oshiki Yumi Watanabe Keiko Kabasawa Akemi Takahashi Shoichiro Tsugane Masayuki Iki Ayako Sasaki Osamu Yamazaki The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol Environmental Health and Preventive Medicine Cohort studies Dementia Musculoskeletal diseases Osteoporotic fractures Vitamin D |
| title | The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol |
| title_full | The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol |
| title_fullStr | The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol |
| title_full_unstemmed | The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol |
| title_short | The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol |
| title_sort | murakami cohort study of vitamin d for the prevention of musculoskeletal and other age related diseases a study protocol |
| topic | Cohort studies Dementia Musculoskeletal diseases Osteoporotic fractures Vitamin D |
| url | http://link.springer.com/article/10.1186/s12199-018-0715-2 |
| work_keys_str_mv | AT kazutoshinakamura themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT ribekatakachi themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT kaorikitamura themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT toshikosaito themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT ryosakukobayashi themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT riekooshiki themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT yumiwatanabe themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT keikokabasawa themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT akemitakahashi themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT shoichirotsugane themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT masayukiiki themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT ayakosasaki themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT osamuyamazaki themurakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT kazutoshinakamura murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT ribekatakachi murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT kaorikitamura murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT toshikosaito murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT ryosakukobayashi murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT riekooshiki murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT yumiwatanabe murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT keikokabasawa murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT akemitakahashi murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT shoichirotsugane murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT masayukiiki murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT ayakosasaki murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol AT osamuyamazaki murakamicohortstudyofvitamindforthepreventionofmusculoskeletalandotheragerelateddiseasesastudyprotocol |