Preparation and physicochemical characterization of N-succinyl chitosan-coated liposomes for oral delivery of grape seed extract and evaluation of its effect on pulmonary fibrosis induced by bleomycin in rats

Objective(s): This study aimed to develop an oral succinyl chitosan-coated liposomal formulation containing grape seed extract and assess its therapeutic efficacy in rats with bleomycin-induced pulmonary fibrosis. Materials and Methods: N-succinyl chitosan was synthesized, and the liposomal formulat...

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Bibliographic Details
Main Authors: Neda Bavarsad, Aliasghar Hemmati, Fateme Jafarian, Azar Mostoufi, Amir Siahpoosh, Mohammadreza Rashidi Nooshabadi, Esrafil Mansouri
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2023-10-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Online Access:https://ijbms.mums.ac.ir/article_22480_ef27fc3ebcdd6235b01bd7e9aa32fd63.pdf