Anti aquaporin 4 positive neuromyelitis optica spectrum disorder and primary Sjögren syndrome following successful therapy for chronic hepatitis C – report of a clinical case
Neuromyelitis optica spectrum disorders (NMOSD) are a heterogeneous group of potentially disabling central nervous system inflammatory disorders. Association with other organ-specific or multisystem autoimmune disorders is commonly encountered. We report the case of a Caucasian woman with AQP4-IgG p...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Amaltea Medical Publishing House
2017-06-01
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| Series: | Romanian Journal of Neurology |
| Subjects: | |
| Online Access: | https://rjn.com.ro/articles/2017.2/RJN_2017_2_Art-07.pdf |
| _version_ | 1811265531930476544 |
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| author | Carmen Predoiu Laura Dumitrescu Adela Danau Liviu Cozma Irina Orban Antonia Lefter Adriana Nicolau Radu Tanasescu |
| author_facet | Carmen Predoiu Laura Dumitrescu Adela Danau Liviu Cozma Irina Orban Antonia Lefter Adriana Nicolau Radu Tanasescu |
| author_sort | Carmen Predoiu |
| collection | DOAJ |
| description | Neuromyelitis optica spectrum disorders (NMOSD) are a heterogeneous group of potentially disabling central nervous system inflammatory disorders. Association with other organ-specific or multisystem autoimmune disorders is commonly encountered. We report the case of a Caucasian woman with AQP4-IgG positive NMOSD and primary Sjögren syndrome - previously reported as a poster at the 14th Congress of the Romanian Society of Neurology (abstract published in ROJN, Vol. XV, Suppl.). The clinical onset followed the successful treatment of chronic hepatitis C with interferon alpha and ribavirin. To the best of our knowledge, similar clinical presentations have not been described. The etiopathogenic treatment included high dose methylprednisolone, immune suppression with cyclophosphamide, and periodic plasma exchanges. In spite of an active disease with very high baseline AQP4-IgG titres, during the four years of treatment the patient has had only one relapse and has no residual disability. |
| first_indexed | 2024-04-12T20:25:29Z |
| format | Article |
| id | doaj.art-d422d0e403c540c696d94771509e4399 |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-04-12T20:25:29Z |
| publishDate | 2017-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-d422d0e403c540c696d94771509e43992022-12-22T03:17:54ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942017-06-01162747710.37897/RJN.2017.2.7Anti aquaporin 4 positive neuromyelitis optica spectrum disorder and primary Sjögren syndrome following successful therapy for chronic hepatitis C – report of a clinical caseCarmen Predoiu0Laura Dumitrescu1Adela Danau2Liviu Cozma3Irina Orban4Antonia Lefter5Adriana Nicolau6Radu Tanasescu7Second Neurology Department, CDPC, Colentina Clinical Hospital, Bucharest, RomaniaSecond Neurology Department, CDPC, Colentina Clinical Hospital, Bucharest, RomaniaSecond Neurology Department, CDPC, Colentina Clinical Hospital, Bucharest, RomaniaSecond Neurology Department, CDPC, Colentina Clinical Hospital, Bucharest, RomaniaSecond Neurology Department, CDPC, Colentina Clinical Hospital, Bucharest, RomaniaSecond Neurology Department, CDPC, Colentina Clinical Hospital, Bucharest, RomaniaInternal Medicine Department, CDPC, Colentina Clinical Hospital, Bucharest, RomaniaSecond Neurology Department, CDPC, Colentina Clinical Hospital, Bucharest, Romania; General Medical School, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania Neuromyelitis optica spectrum disorders (NMOSD) are a heterogeneous group of potentially disabling central nervous system inflammatory disorders. Association with other organ-specific or multisystem autoimmune disorders is commonly encountered. We report the case of a Caucasian woman with AQP4-IgG positive NMOSD and primary Sjögren syndrome - previously reported as a poster at the 14th Congress of the Romanian Society of Neurology (abstract published in ROJN, Vol. XV, Suppl.). The clinical onset followed the successful treatment of chronic hepatitis C with interferon alpha and ribavirin. To the best of our knowledge, similar clinical presentations have not been described. The etiopathogenic treatment included high dose methylprednisolone, immune suppression with cyclophosphamide, and periodic plasma exchanges. In spite of an active disease with very high baseline AQP4-IgG titres, during the four years of treatment the patient has had only one relapse and has no residual disability.https://rjn.com.ro/articles/2017.2/RJN_2017_2_Art-07.pdfneuromyelitis optica spectrum disordersaqp4-iggsjögren syndromechronic hepatitis cinterferon alpha |
| spellingShingle | Carmen Predoiu Laura Dumitrescu Adela Danau Liviu Cozma Irina Orban Antonia Lefter Adriana Nicolau Radu Tanasescu Anti aquaporin 4 positive neuromyelitis optica spectrum disorder and primary Sjögren syndrome following successful therapy for chronic hepatitis C – report of a clinical case Romanian Journal of Neurology neuromyelitis optica spectrum disorders aqp4-igg sjögren syndrome chronic hepatitis c interferon alpha |
| title | Anti aquaporin 4 positive neuromyelitis optica spectrum disorder and primary Sjögren syndrome following successful therapy for chronic hepatitis C – report of a clinical case |
| title_full | Anti aquaporin 4 positive neuromyelitis optica spectrum disorder and primary Sjögren syndrome following successful therapy for chronic hepatitis C – report of a clinical case |
| title_fullStr | Anti aquaporin 4 positive neuromyelitis optica spectrum disorder and primary Sjögren syndrome following successful therapy for chronic hepatitis C – report of a clinical case |
| title_full_unstemmed | Anti aquaporin 4 positive neuromyelitis optica spectrum disorder and primary Sjögren syndrome following successful therapy for chronic hepatitis C – report of a clinical case |
| title_short | Anti aquaporin 4 positive neuromyelitis optica spectrum disorder and primary Sjögren syndrome following successful therapy for chronic hepatitis C – report of a clinical case |
| title_sort | anti aquaporin 4 positive neuromyelitis optica spectrum disorder and primary sjogren syndrome following successful therapy for chronic hepatitis c report of a clinical case |
| topic | neuromyelitis optica spectrum disorders aqp4-igg sjögren syndrome chronic hepatitis c interferon alpha |
| url | https://rjn.com.ro/articles/2017.2/RJN_2017_2_Art-07.pdf |
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