The role of ethnicity, biological sex, and psychotropic agents in early and late onset Alzheimer’s disease
ObjectiveThis study investigates differences in pharmacological and demographic factors among male and female patients with Late-onset Alzheimer’s disease (LOAD) and Early-onset Alzheimer’s disease (EOAD).MethodData are from 10,126 AD patients, 9,290 were diagnosed with LOAD, while 836 were diagnose...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1052330/full |
| _version_ | 1797979195730558976 |
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| author | Alyssa Miller Ashna Desai Laurie Theriot Roley Richard L. Goodwin Adebobola I. Nathaniel Thomas I. Nathaniel |
| author_facet | Alyssa Miller Ashna Desai Laurie Theriot Roley Richard L. Goodwin Adebobola I. Nathaniel Thomas I. Nathaniel |
| author_sort | Alyssa Miller |
| collection | DOAJ |
| description | ObjectiveThis study investigates differences in pharmacological and demographic factors among male and female patients with Late-onset Alzheimer’s disease (LOAD) and Early-onset Alzheimer’s disease (EOAD).MethodData are from 10,126 AD patients, 9,290 were diagnosed with LOAD, while 836 were diagnosed with EOAD. Data were collected from the Prisma Health Upstate Alzheimer’s patients’ registry between 2016 and 2021. The logistic regression analysis was used to assess the association between pharmacological and demographic factors in males and females with LOAD and EOAD.ResultsIn the adjusted analysis for males, patients that were administered memantine [odd ratio (OR) = 1.588, 95% CI, 1.175–2.145, p = 0.003], and buspirone [OR = 1.971, 95% CI, 1.221–3.183, p = 0.006] were more likely to be associated with EOAD, while increasing age [OR = 0.816, 95% CI, 0.799–0.834, p < 0.001] was associated with LOAD. Female patients with a history of alcohol (ETOH) use were more likely to be associated with EOAD while increasing age [OR = 0.845, 95% CI, 0.834–0.857, p < 0.001], treatment with memantine [OR = 0.774, 95% CI, 0.627–0.956, p = 0.017], African Americans [OR = 0.621, 95% CI, 0.462–0.835, p = 0.002] and tobacco use [OR = 0.529, 95% CI, 0.424–0.660, p < 0.001] were associated with LOAD.ConclusionOur findings identified specific demographic and pharmacological factors associated with males and females with LOAD and EOAD. These findings suggest the need to develop strategies to eliminate disparity in the care of LOAD or EOAD patients. |
| first_indexed | 2024-04-11T05:35:10Z |
| format | Article |
| id | doaj.art-d425733cfd1e4c7085fe71aa7e4b8579 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T05:35:10Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-d425733cfd1e4c7085fe71aa7e4b85792022-12-22T14:27:25ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-12-011410.3389/fnagi.2022.10523301052330The role of ethnicity, biological sex, and psychotropic agents in early and late onset Alzheimer’s diseaseAlyssa Miller0Ashna Desai1Laurie Theriot Roley2Richard L. Goodwin3Adebobola I. Nathaniel4Thomas I. Nathaniel5Department of Biology, North Greenville University, Tigerville, SC, United StatesDepartment of Biology, University of South Carolina, Columbia, SC, United StatesDepartment of Geriatric Medicine, Prisma Health, Greer, SC, United StatesSchool of Medicine Greenville, University of South Carolina, Greenville, SC, United StatesDepartment of Biology, North Greenville University, Tigerville, SC, United StatesSchool of Medicine Greenville, University of South Carolina, Greenville, SC, United StatesObjectiveThis study investigates differences in pharmacological and demographic factors among male and female patients with Late-onset Alzheimer’s disease (LOAD) and Early-onset Alzheimer’s disease (EOAD).MethodData are from 10,126 AD patients, 9,290 were diagnosed with LOAD, while 836 were diagnosed with EOAD. Data were collected from the Prisma Health Upstate Alzheimer’s patients’ registry between 2016 and 2021. The logistic regression analysis was used to assess the association between pharmacological and demographic factors in males and females with LOAD and EOAD.ResultsIn the adjusted analysis for males, patients that were administered memantine [odd ratio (OR) = 1.588, 95% CI, 1.175–2.145, p = 0.003], and buspirone [OR = 1.971, 95% CI, 1.221–3.183, p = 0.006] were more likely to be associated with EOAD, while increasing age [OR = 0.816, 95% CI, 0.799–0.834, p < 0.001] was associated with LOAD. Female patients with a history of alcohol (ETOH) use were more likely to be associated with EOAD while increasing age [OR = 0.845, 95% CI, 0.834–0.857, p < 0.001], treatment with memantine [OR = 0.774, 95% CI, 0.627–0.956, p = 0.017], African Americans [OR = 0.621, 95% CI, 0.462–0.835, p = 0.002] and tobacco use [OR = 0.529, 95% CI, 0.424–0.660, p < 0.001] were associated with LOAD.ConclusionOur findings identified specific demographic and pharmacological factors associated with males and females with LOAD and EOAD. These findings suggest the need to develop strategies to eliminate disparity in the care of LOAD or EOAD patients.https://www.frontiersin.org/articles/10.3389/fnagi.2022.1052330/fullAlzheimer’s diseaselate onset of Alzheimer’s diseaseearly onset of Alzheimer’s diseasemalefemale |
| spellingShingle | Alyssa Miller Ashna Desai Laurie Theriot Roley Richard L. Goodwin Adebobola I. Nathaniel Thomas I. Nathaniel The role of ethnicity, biological sex, and psychotropic agents in early and late onset Alzheimer’s disease Frontiers in Aging Neuroscience Alzheimer’s disease late onset of Alzheimer’s disease early onset of Alzheimer’s disease male female |
| title | The role of ethnicity, biological sex, and psychotropic agents in early and late onset Alzheimer’s disease |
| title_full | The role of ethnicity, biological sex, and psychotropic agents in early and late onset Alzheimer’s disease |
| title_fullStr | The role of ethnicity, biological sex, and psychotropic agents in early and late onset Alzheimer’s disease |
| title_full_unstemmed | The role of ethnicity, biological sex, and psychotropic agents in early and late onset Alzheimer’s disease |
| title_short | The role of ethnicity, biological sex, and psychotropic agents in early and late onset Alzheimer’s disease |
| title_sort | role of ethnicity biological sex and psychotropic agents in early and late onset alzheimer s disease |
| topic | Alzheimer’s disease late onset of Alzheimer’s disease early onset of Alzheimer’s disease male female |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1052330/full |
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