Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination
Summary: Co-transmission of multiple neurotransmitters from a single neuron increases the complexity of signaling information within defined neuronal circuits. Superficial short-axon cells in the olfactory bulb release both dopamine and γ-aminobutyric acid (GABA), yet the specific targets of these n...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723014833 |
| _version_ | 1797564979275104256 |
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| author | Ariel M. Lyons-Warren Evelyne K. Tantry Elizabeth H. Moss Mikhail Y. Kochukov Benjamin D.W. Belfort Joshua Ortiz-Guzman Zachary Freyberg Benjamin R. Arenkiel |
| author_facet | Ariel M. Lyons-Warren Evelyne K. Tantry Elizabeth H. Moss Mikhail Y. Kochukov Benjamin D.W. Belfort Joshua Ortiz-Guzman Zachary Freyberg Benjamin R. Arenkiel |
| author_sort | Ariel M. Lyons-Warren |
| collection | DOAJ |
| description | Summary: Co-transmission of multiple neurotransmitters from a single neuron increases the complexity of signaling information within defined neuronal circuits. Superficial short-axon cells in the olfactory bulb release both dopamine and γ-aminobutyric acid (GABA), yet the specific targets of these neurotransmitters and their respective roles in olfaction have remained unknown. Here, we implement intersectional genetics in mice to selectively block GABA or dopamine release from superficial short-axon cells to identify their distinct cellular targets, impact on circuit function, and behavioral contribution of each neurotransmitter toward olfactory behaviors. We provide functional and anatomical evidence for divergent superficial short-axon cell signaling onto downstream neurons to shape patterns of mitral cell firing that contribute to olfactory-related behaviors. |
| first_indexed | 2024-03-10T19:05:29Z |
| format | Article |
| id | doaj.art-d426480f99f24a6a8a652cb6c1443abd |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-10T19:05:29Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-d426480f99f24a6a8a652cb6c1443abd2023-11-20T04:11:42ZengElsevierCell Reports2211-12472023-12-014212113471Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discriminationAriel M. Lyons-Warren0Evelyne K. Tantry1Elizabeth H. Moss2Mikhail Y. Kochukov3Benjamin D.W. Belfort4Joshua Ortiz-Guzman5Zachary Freyberg6Benjamin R. Arenkiel7Department of Pediatrics, Section of Pediatric Neurology and Developmental Neuroscience, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, 1250 Moursund Street, Houston, TX 77030, USADepartment of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, 1250 Moursund Street, Houston, TX 77030, USADepartment of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, 1250 Moursund Street, Houston, TX 77030, USADepartment of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, 1250 Moursund Street, Houston, TX 77030, USADepartment of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, 1250 Moursund Street, Houston, TX 77030, USA; Medical Scientist Training Program, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USADepartment of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, 1250 Moursund Street, Houston, TX 77030, USADepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Molecular and Human Genetics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, 1250 Moursund Street, Houston, TX 77030, USA; Corresponding authorSummary: Co-transmission of multiple neurotransmitters from a single neuron increases the complexity of signaling information within defined neuronal circuits. Superficial short-axon cells in the olfactory bulb release both dopamine and γ-aminobutyric acid (GABA), yet the specific targets of these neurotransmitters and their respective roles in olfaction have remained unknown. Here, we implement intersectional genetics in mice to selectively block GABA or dopamine release from superficial short-axon cells to identify their distinct cellular targets, impact on circuit function, and behavioral contribution of each neurotransmitter toward olfactory behaviors. We provide functional and anatomical evidence for divergent superficial short-axon cell signaling onto downstream neurons to shape patterns of mitral cell firing that contribute to olfactory-related behaviors.http://www.sciencedirect.com/science/article/pii/S2211124723014833CP: Neuroscience |
| spellingShingle | Ariel M. Lyons-Warren Evelyne K. Tantry Elizabeth H. Moss Mikhail Y. Kochukov Benjamin D.W. Belfort Joshua Ortiz-Guzman Zachary Freyberg Benjamin R. Arenkiel Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination Cell Reports CP: Neuroscience |
| title | Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination |
| title_full | Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination |
| title_fullStr | Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination |
| title_full_unstemmed | Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination |
| title_short | Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination |
| title_sort | co transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723014833 |
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