Association of ApE1 gene Asp148Glu polymorphism and idiopathic male infertility
Background and Objective: Despite enormous progress in the understanding of human reproductive physiology, the underlying cause of male infertility remains undefined in about 50.0% of cases, which are referred to as idiopathic infertility and affects about 5.0-7.0% of the general male population. Hu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
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Golestan University of Medical Sciences
2015-06-01
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| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-833&slc_lang=en&sid=1 |
| _version_ | 1811257833035923456 |
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| author | Yousefi M Salehi Z Mashayekhi F Bahadori MH |
| author_facet | Yousefi M Salehi Z Mashayekhi F Bahadori MH |
| author_sort | Yousefi M |
| collection | DOAJ |
| description | Background and Objective: Despite enormous progress in the understanding of human reproductive physiology, the underlying cause of male infertility remains undefined in about 50.0% of cases, which are referred to as idiopathic infertility and affects about 5.0-7.0% of the general male population. Human apurinic/apyrimidinic endonuclease (ApE1) is a multifunctional protein that has an important role in the base excision repair (BER) pathway. ApE1 SNP T>G found in exon 5 led to substitution of Asp>Glu at codon 148. This study was done to evaluate the association of ApE1 Asp148Glu polymorphism and the risk of idiopathic male infertility. Methods: In this case-control study, blood samples were collected from 90 patients diagnosed with idiopathic male infertility and 90 healthy men, genotyped by Allele-Specific PCR (AS-PCR) method by using specific primers that were designed and the association between genotype and allele frequencies in cases and controls were estimated. Results: There was no significant association between ApE1 gene polymorphism at codon 148 in case and control groups. Conclusion: No significant association was found between the Asp148Glu polymorphism and idiopathic male infertility. |
| first_indexed | 2024-04-12T18:03:41Z |
| format | Article |
| id | doaj.art-d427013d4dfe4c9596532b5b0bfaea1b |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-04-12T18:03:41Z |
| publishDate | 2015-06-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-d427013d4dfe4c9596532b5b0bfaea1b2022-12-22T03:22:04ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802015-06-011728791Association of ApE1 gene Asp148Glu polymorphism and idiopathic male infertilityYousefi M0Salehi Z1Mashayekhi F2Bahadori MH3 M.Sc student in Cell and Developmental Biology, Faculty of Sciences, University of Guilan, Rasht, Iran Professor, Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran Professor, Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran Associate Professor, Cellular and Molecular Research Center, Faculty of Medical Sciences, Guilan University of Medical Sciences, Rasht, Iran Background and Objective: Despite enormous progress in the understanding of human reproductive physiology, the underlying cause of male infertility remains undefined in about 50.0% of cases, which are referred to as idiopathic infertility and affects about 5.0-7.0% of the general male population. Human apurinic/apyrimidinic endonuclease (ApE1) is a multifunctional protein that has an important role in the base excision repair (BER) pathway. ApE1 SNP T>G found in exon 5 led to substitution of Asp>Glu at codon 148. This study was done to evaluate the association of ApE1 Asp148Glu polymorphism and the risk of idiopathic male infertility. Methods: In this case-control study, blood samples were collected from 90 patients diagnosed with idiopathic male infertility and 90 healthy men, genotyped by Allele-Specific PCR (AS-PCR) method by using specific primers that were designed and the association between genotype and allele frequencies in cases and controls were estimated. Results: There was no significant association between ApE1 gene polymorphism at codon 148 in case and control groups. Conclusion: No significant association was found between the Asp148Glu polymorphism and idiopathic male infertility.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-833&slc_lang=en&sid=1InfertilityMalePolymorphismApE1 gene |
| spellingShingle | Yousefi M Salehi Z Mashayekhi F Bahadori MH Association of ApE1 gene Asp148Glu polymorphism and idiopathic male infertility مجله دانشگاه علوم پزشکی گرگان Infertility Male Polymorphism ApE1 gene |
| title | Association of ApE1 gene Asp148Glu polymorphism and idiopathic male infertility |
| title_full | Association of ApE1 gene Asp148Glu polymorphism and idiopathic male infertility |
| title_fullStr | Association of ApE1 gene Asp148Glu polymorphism and idiopathic male infertility |
| title_full_unstemmed | Association of ApE1 gene Asp148Glu polymorphism and idiopathic male infertility |
| title_short | Association of ApE1 gene Asp148Glu polymorphism and idiopathic male infertility |
| title_sort | association of ape1 gene asp148glu polymorphism and idiopathic male infertility |
| topic | Infertility Male Polymorphism ApE1 gene |
| url | http://goums.ac.ir/journal/browse.php?a_code=A-10-1-833&slc_lang=en&sid=1 |
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