BioCloneBot: A versatile, low-cost, and open-source automated liquid handler

Liquid handler systems can provide significant benefits to researchers by automating laboratory work, however, their unaffordable price provides a steep barrier to entry. Therefore, we provide the BioCloneBot, a versatile, low-cost, and open-source automated liquid handler. This system can be easily...

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Main Authors: Ke’Koa CDH Wells, Nawwaf Kharma, Brandon B. Jaunky, Kaiyu Nie, Gabriel Aguiar-Tawil, Daniel Berry
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:HardwareX
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2468067224000105
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author Ke’Koa CDH Wells
Nawwaf Kharma
Brandon B. Jaunky
Kaiyu Nie
Gabriel Aguiar-Tawil
Daniel Berry
author_facet Ke’Koa CDH Wells
Nawwaf Kharma
Brandon B. Jaunky
Kaiyu Nie
Gabriel Aguiar-Tawil
Daniel Berry
author_sort Ke’Koa CDH Wells
collection DOAJ
description Liquid handler systems can provide significant benefits to researchers by automating laboratory work, however, their unaffordable price provides a steep barrier to entry. Therefore, we provide the BioCloneBot, a versatile, low-cost, and open-source automated liquid handler. This system can be easily built with 3D-printed parts and readily available commercial components. The BioCloneBot is highly adaptive to user needs and facilitates various liquid handling tasks in research and diagnostics. Its user-friendly interface and programmable nature make it suitable for a wide range of applications, from small-scale experiments to larger laboratory setups. By utilizing BioCloneBot, researchers and scientists can streamline their liquid handling processes without the financial constraints posed by traditional systems. In this paper, we detail the design, construction, and validation of BioCloneBot, showcasing its precise control, accuracy, and repeatability in various liquid handling tasks. The open-source nature of the system encourages collaboration and customization, enabling researchers to contribute and adapt the technology to specific experimental requirements.
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spelling doaj.art-d427e1715f404216aae32a0657ef77122024-06-13T04:45:23ZengElsevierHardwareX2468-06722024-06-0118e00516BioCloneBot: A versatile, low-cost, and open-source automated liquid handlerKe’Koa CDH Wells0Nawwaf Kharma1Brandon B. Jaunky2Kaiyu Nie3Gabriel Aguiar-Tawil4Daniel Berry5Department of Electrical and Computer Engineering, Concordia University, Montréal, Québec, CanadaDepartment of Electrical and Computer Engineering, Concordia University, Montréal, Québec, Canada; Department of Biology, Concordia University, Montréal, Québec, Canada; Corresponding author at: Department of Electrical and Computer Engineering, Concordia University, Montréal, Québec, Canada.Department of Biology, Concordia University, Montréal, Québec, CanadaDepartment of Electrical and Computer Engineering, Concordia University, Montréal, Québec, CanadaDepartment of Biology, Concordia University, Montréal, Québec, CanadaDepartment of Mechanical, Industrial and Aerospace Engineering, Concordia University, Montréal, Québec, CanadaLiquid handler systems can provide significant benefits to researchers by automating laboratory work, however, their unaffordable price provides a steep barrier to entry. Therefore, we provide the BioCloneBot, a versatile, low-cost, and open-source automated liquid handler. This system can be easily built with 3D-printed parts and readily available commercial components. The BioCloneBot is highly adaptive to user needs and facilitates various liquid handling tasks in research and diagnostics. Its user-friendly interface and programmable nature make it suitable for a wide range of applications, from small-scale experiments to larger laboratory setups. By utilizing BioCloneBot, researchers and scientists can streamline their liquid handling processes without the financial constraints posed by traditional systems. In this paper, we detail the design, construction, and validation of BioCloneBot, showcasing its precise control, accuracy, and repeatability in various liquid handling tasks. The open-source nature of the system encourages collaboration and customization, enabling researchers to contribute and adapt the technology to specific experimental requirements.http://www.sciencedirect.com/science/article/pii/S2468067224000105Open-sourceLiquid handlerSynthetic biologyDNA cloning3D printing
spellingShingle Ke’Koa CDH Wells
Nawwaf Kharma
Brandon B. Jaunky
Kaiyu Nie
Gabriel Aguiar-Tawil
Daniel Berry
BioCloneBot: A versatile, low-cost, and open-source automated liquid handler
HardwareX
Open-source
Liquid handler
Synthetic biology
DNA cloning
3D printing
title BioCloneBot: A versatile, low-cost, and open-source automated liquid handler
title_full BioCloneBot: A versatile, low-cost, and open-source automated liquid handler
title_fullStr BioCloneBot: A versatile, low-cost, and open-source automated liquid handler
title_full_unstemmed BioCloneBot: A versatile, low-cost, and open-source automated liquid handler
title_short BioCloneBot: A versatile, low-cost, and open-source automated liquid handler
title_sort bioclonebot a versatile low cost and open source automated liquid handler
topic Open-source
Liquid handler
Synthetic biology
DNA cloning
3D printing
url http://www.sciencedirect.com/science/article/pii/S2468067224000105
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