Nurse empowerment through Pharmacogenetics
Objective: to verify the existence of elements that justify the use of pharmacogenetics by the Brazilian nurse. Method: this is a quantitative, cross-sectional, observational, descriptive study, whose final sample was 67 individuals. The participants were healthy at the time of the study and report...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
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| Series: | Revista Latino-Americana de Enfermagem |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-11692020000100377&tlng=pt |
| _version_ | 1818891190819356672 |
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| author | Jordana Carvalhaes de Moraes Fernanda Daniela Dornelas Nunes Fernanda Borchers Coeli-Lacchini Anderson Heiji Lima Miyazaki Milena Flória-Santos Riccardo Lacchini |
| author_facet | Jordana Carvalhaes de Moraes Fernanda Daniela Dornelas Nunes Fernanda Borchers Coeli-Lacchini Anderson Heiji Lima Miyazaki Milena Flória-Santos Riccardo Lacchini |
| author_sort | Jordana Carvalhaes de Moraes |
| collection | DOAJ |
| description | Objective: to verify the existence of elements that justify the use of pharmacogenetics by the Brazilian nurse. Method: this is a quantitative, cross-sectional, observational, descriptive study, whose final sample was 67 individuals. The participants were healthy at the time of the study and reported a history of previous use and the occurrence of adverse effects by drugs commonly used and metabolized by CYP2C9. We collected 4 mL of venous blood for subsequent DNA extraction by salting out method and genotyping of the CYP2C9*2 and CYP2C9*3 polymorphisms, using Polymerase Chain Reaction in real time using Taqman assays. Results: the use of drugs metabolized by CYP2C9 was frequent (more than 75% of the individuals have already used between 2 or 4 of these drugs). Regarding adverse events, there were 19 perceived symptomatic occurrences associated with drugs metabolized by CYP2C9. The allele frequency of the polymorphism * 2 and * 3 in the population studied was 11.1% and 7.5%, respectively, and there was a coincidence between the presence of alleles of low enzyme activity and the occurrence of adverse effects. Conclusion: there are elements that justify the adoption of pharmacogenetics in the nursing care to reduce the occurrence of adverse reactions to drugs metabolized by CYP2C9. |
| first_indexed | 2024-12-19T17:36:53Z |
| format | Article |
| id | doaj.art-d42801cc65ac4f299433f7d0dfe61698 |
| institution | Directory Open Access Journal |
| issn | 1518-8345 |
| language | English |
| last_indexed | 2024-12-19T17:36:53Z |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Revista Latino-Americana de Enfermagem |
| spelling | doaj.art-d42801cc65ac4f299433f7d0dfe616982022-12-21T20:12:18ZengUniversidade de São PauloRevista Latino-Americana de Enfermagem1518-834510.1590/1518-8345.3415.3265Nurse empowerment through PharmacogeneticsJordana Carvalhaes de MoraesFernanda Daniela Dornelas NunesFernanda Borchers Coeli-LacchiniAnderson Heiji Lima MiyazakiMilena Flória-SantosRiccardo LacchiniObjective: to verify the existence of elements that justify the use of pharmacogenetics by the Brazilian nurse. Method: this is a quantitative, cross-sectional, observational, descriptive study, whose final sample was 67 individuals. The participants were healthy at the time of the study and reported a history of previous use and the occurrence of adverse effects by drugs commonly used and metabolized by CYP2C9. We collected 4 mL of venous blood for subsequent DNA extraction by salting out method and genotyping of the CYP2C9*2 and CYP2C9*3 polymorphisms, using Polymerase Chain Reaction in real time using Taqman assays. Results: the use of drugs metabolized by CYP2C9 was frequent (more than 75% of the individuals have already used between 2 or 4 of these drugs). Regarding adverse events, there were 19 perceived symptomatic occurrences associated with drugs metabolized by CYP2C9. The allele frequency of the polymorphism * 2 and * 3 in the population studied was 11.1% and 7.5%, respectively, and there was a coincidence between the presence of alleles of low enzyme activity and the occurrence of adverse effects. Conclusion: there are elements that justify the adoption of pharmacogenetics in the nursing care to reduce the occurrence of adverse reactions to drugs metabolized by CYP2C9.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-11692020000100377&tlng=ptCytochrome P-450 CYP2C9PharmacogeneticsDrug-Related Side EffectsAdverse ReactionsNursingNursing Process |
| spellingShingle | Jordana Carvalhaes de Moraes Fernanda Daniela Dornelas Nunes Fernanda Borchers Coeli-Lacchini Anderson Heiji Lima Miyazaki Milena Flória-Santos Riccardo Lacchini Nurse empowerment through Pharmacogenetics Revista Latino-Americana de Enfermagem Cytochrome P-450 CYP2C9 Pharmacogenetics Drug-Related Side Effects Adverse Reactions Nursing Nursing Process |
| title | Nurse empowerment through Pharmacogenetics |
| title_full | Nurse empowerment through Pharmacogenetics |
| title_fullStr | Nurse empowerment through Pharmacogenetics |
| title_full_unstemmed | Nurse empowerment through Pharmacogenetics |
| title_short | Nurse empowerment through Pharmacogenetics |
| title_sort | nurse empowerment through pharmacogenetics |
| topic | Cytochrome P-450 CYP2C9 Pharmacogenetics Drug-Related Side Effects Adverse Reactions Nursing Nursing Process |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-11692020000100377&tlng=pt |
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