Novel mechanisms of immune evasion by Schistosoma mansoni
The interaction of Schistosoma mansoni with its host's immune system is largely affected by multiple specific and non-specific evasion mechanisms employed by the parasite to reduce the host's immune reactivity. Only little is known about these mechanisms on the molecular level. The four mo...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1995-03-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200029 |
| _version_ | 1797757922867937280 |
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| author | Zvi Fishelson |
| author_facet | Zvi Fishelson |
| author_sort | Zvi Fishelson |
| collection | DOAJ |
| description | The interaction of Schistosoma mansoni with its host's immune system is largely affected by multiple specific and non-specific evasion mechanisms employed by the parasite to reduce the host's immune reactivity. Only little is known about these mechanisms on the molecular level. The four molecules described below are intrinsic parasitic proteins recently identified and studied in our laboratory. 1. m28-A 28kDa membrane serine protease. m28 cleaves iC3b and can thus restrict attack by effector cells utilizing complement receptors (especially CR3). Treatment with protease inhibitors potentiates killing of schistosomula by complement plus neutrophils. 2. Smpi56-A 56kDa serine protease inhibitor. Smpi56 binds covalently to m28 and to neutrophil's elastase and blocks their proteolytic activity. 3. P70-A 70kDa C3b binding protein. The postulated activity of P70 includes binding to C3b and blocking of complement activation of the C3 step. 4. SCIP-1-A 94kDa schistosome complement inhibitor. SCIP-1 shows antigenic and functional similarities to the human 18kDa complement inhibitor CD59. Like CD59, SCIP-1 binds to C8 and C9 and blocks formation of the complement membrane attack complex. Antibodies directed to human CD59 bind to schistosomula and potentiate their killing by complement. The structure and function of these four proteins as well as their capacity to induce protection from infection with S. mansoni are under investigation. |
| first_indexed | 2024-03-12T18:22:33Z |
| format | Article |
| id | doaj.art-d428824ba48143a79fb632669e8e6ce9 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:22:33Z |
| publishDate | 1995-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-d428824ba48143a79fb632669e8e6ce92023-08-02T08:46:54ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601995-03-0190228929210.1590/S0074-02761995000200029Novel mechanisms of immune evasion by Schistosoma mansoniZvi FishelsonThe interaction of Schistosoma mansoni with its host's immune system is largely affected by multiple specific and non-specific evasion mechanisms employed by the parasite to reduce the host's immune reactivity. Only little is known about these mechanisms on the molecular level. The four molecules described below are intrinsic parasitic proteins recently identified and studied in our laboratory. 1. m28-A 28kDa membrane serine protease. m28 cleaves iC3b and can thus restrict attack by effector cells utilizing complement receptors (especially CR3). Treatment with protease inhibitors potentiates killing of schistosomula by complement plus neutrophils. 2. Smpi56-A 56kDa serine protease inhibitor. Smpi56 binds covalently to m28 and to neutrophil's elastase and blocks their proteolytic activity. 3. P70-A 70kDa C3b binding protein. The postulated activity of P70 includes binding to C3b and blocking of complement activation of the C3 step. 4. SCIP-1-A 94kDa schistosome complement inhibitor. SCIP-1 shows antigenic and functional similarities to the human 18kDa complement inhibitor CD59. Like CD59, SCIP-1 binds to C8 and C9 and blocks formation of the complement membrane attack complex. Antibodies directed to human CD59 bind to schistosomula and potentiate their killing by complement. The structure and function of these four proteins as well as their capacity to induce protection from infection with S. mansoni are under investigation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200029immune evasioncomplementproteaseinhibitorCD59 |
| spellingShingle | Zvi Fishelson Novel mechanisms of immune evasion by Schistosoma mansoni Memorias do Instituto Oswaldo Cruz immune evasion complement protease inhibitor CD59 |
| title | Novel mechanisms of immune evasion by Schistosoma mansoni |
| title_full | Novel mechanisms of immune evasion by Schistosoma mansoni |
| title_fullStr | Novel mechanisms of immune evasion by Schistosoma mansoni |
| title_full_unstemmed | Novel mechanisms of immune evasion by Schistosoma mansoni |
| title_short | Novel mechanisms of immune evasion by Schistosoma mansoni |
| title_sort | novel mechanisms of immune evasion by schistosoma mansoni |
| topic | immune evasion complement protease inhibitor CD59 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200029 |
| work_keys_str_mv | AT zvifishelson novelmechanismsofimmuneevasionbyschistosomamansoni |