The impact of Mir-9 regulation in normal and malignant hematopoiesis
MicroRNA-9 (MiR-9) dysregulation has been observed in various cancers. Recently, MiR-9 is considered to have a part in hematopoiesis and hematologic malignancies. However, its importance in blood neoplasms is not yet well defined. Thus, this study was conducted in order to assess the significance of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | http://www.oncologyreviews.org/index.php/or/article/view/348 |
| _version_ | 1797963110458327040 |
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| author | Abbas Khosravi Shaban Alizadeh Arsalan Jalili Reza Shirzad Najmaldin Saki |
| author_facet | Abbas Khosravi Shaban Alizadeh Arsalan Jalili Reza Shirzad Najmaldin Saki |
| author_sort | Abbas Khosravi |
| collection | DOAJ |
| description | MicroRNA-9 (MiR-9) dysregulation has been observed in various cancers. Recently, MiR-9 is considered to have a part in hematopoiesis and hematologic malignancies. However, its importance in blood neoplasms is not yet well defined. Thus, this study was conducted in order to assess the significance of MiR-9 role in the development of hematologic neoplasia, prognosis, and treatment approaches. We have shown that a large number of MiR-9 targets (such as FOXOs, SIRT1, CCND1, ID2, CCNG1, Ets, and NFkB) play essential roles in leukemogenesis and that it is overexpressed in different leukemias. Our findings indicated MiR-9 downregulation in a majority of leukemias. However, its overexpression was reported in patients with dysregulated MiR-9 controlling factors (such as MLLr). Additionally, prognostic value of MiR-9 has been reported in some types of leukemia. This study generally emphasizes on the critical role of MiR-9 in hematologic malignancies as a prognostic factor and a therapeutic target. |
| first_indexed | 2024-04-11T01:23:12Z |
| format | Article |
| id | doaj.art-d429596da8de44af92dddcf4bae614bb |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T01:23:12Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-d429596da8de44af92dddcf4bae614bb2023-01-03T10:59:53ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652018-03-0112110.4081/oncol.2018.348The impact of Mir-9 regulation in normal and malignant hematopoiesisAbbas Khosravi0Shaban Alizadeh1Arsalan Jalili2Reza Shirzad3Najmaldin Saki4Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, TehranHematology Department, Allied Medical School, Tehran University of Medical Sciences, TehranDepartment of Stem Cells and Developmental Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, TehranWHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, TehranThalassemia & Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, AhvazMicroRNA-9 (MiR-9) dysregulation has been observed in various cancers. Recently, MiR-9 is considered to have a part in hematopoiesis and hematologic malignancies. However, its importance in blood neoplasms is not yet well defined. Thus, this study was conducted in order to assess the significance of MiR-9 role in the development of hematologic neoplasia, prognosis, and treatment approaches. We have shown that a large number of MiR-9 targets (such as FOXOs, SIRT1, CCND1, ID2, CCNG1, Ets, and NFkB) play essential roles in leukemogenesis and that it is overexpressed in different leukemias. Our findings indicated MiR-9 downregulation in a majority of leukemias. However, its overexpression was reported in patients with dysregulated MiR-9 controlling factors (such as MLLr). Additionally, prognostic value of MiR-9 has been reported in some types of leukemia. This study generally emphasizes on the critical role of MiR-9 in hematologic malignancies as a prognostic factor and a therapeutic target.http://www.oncologyreviews.org/index.php/or/article/view/348MiR-9leukemiatumor suppressoroncogene |
| spellingShingle | Abbas Khosravi Shaban Alizadeh Arsalan Jalili Reza Shirzad Najmaldin Saki The impact of Mir-9 regulation in normal and malignant hematopoiesis Oncology Reviews MiR-9 leukemia tumor suppressor oncogene |
| title | The impact of Mir-9 regulation in normal and malignant hematopoiesis |
| title_full | The impact of Mir-9 regulation in normal and malignant hematopoiesis |
| title_fullStr | The impact of Mir-9 regulation in normal and malignant hematopoiesis |
| title_full_unstemmed | The impact of Mir-9 regulation in normal and malignant hematopoiesis |
| title_short | The impact of Mir-9 regulation in normal and malignant hematopoiesis |
| title_sort | impact of mir 9 regulation in normal and malignant hematopoiesis |
| topic | MiR-9 leukemia tumor suppressor oncogene |
| url | http://www.oncologyreviews.org/index.php/or/article/view/348 |
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