Endoplasmic Reticulum Chemical Chaperone 3‐Hydroxy‐2‐Naphthoic Acid Reduces Angiotensin II‐Induced Vascular Remodeling and Hypertension In Vivo and Protein Synthesis In Vitro

Endoplasmic Reticulum Chemical Chaperone 3‐Hydroxy‐2‐Naphthoic Acid Reduces Angiotensin II‐Induced Vascular Remodeling and Hypertension In Vivo and Protein Synthesis In Vitro

Background Investigations into alternative treatments for hypertension are necessary because current treatments cannot fully reduce the risk for the development of cardiovascular diseases. Chronic activation of unfolded protein response attributable to the endoplasmic reticulum stress has been propo...

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Bibliographic Details
Main Authors: Stephanie Cicalese, Keiichi Torimoto, Keisuke Okuno, Katherine J. Elliott, Victor Rizzo, Tomoki Hashimoto, Satoru Eguchi
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
angiotensin II
ER stress
hypertension
vascular fibrosis
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.122.028201

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