Long-term effects of malnutrition on severity of COVID-19
Abstract The COVID-19 pandemic is a public health crisis that has the potential to exacerbate worldwide malnutrition. This study examines whether patients with a history of malnutrition are predisposed to severe COVID-19. To do so, data on 103,099 COVID-19 inpatient encounters from 56 hospitals in t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-94138-z |
| _version_ | 1818430539736023040 |
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| author | Alec Kurtz Kenneth Grant Rachel Marano Antonio Arrieta Kenneth Grant William Feaster Caroline Steele Louis Ehwerhemuepha |
| author_facet | Alec Kurtz Kenneth Grant Rachel Marano Antonio Arrieta Kenneth Grant William Feaster Caroline Steele Louis Ehwerhemuepha |
| author_sort | Alec Kurtz |
| collection | DOAJ |
| description | Abstract The COVID-19 pandemic is a public health crisis that has the potential to exacerbate worldwide malnutrition. This study examines whether patients with a history of malnutrition are predisposed to severe COVID-19. To do so, data on 103,099 COVID-19 inpatient encounters from 56 hospitals in the United States between March 2020 and June 2020 were retrieved from the Cerner COVID-19 Dataset. Patients with a history of malnutrition between 2015 and 2019 were identified, and a random intercept logistic regression models for pediatric and adult patients were built controlling for patient demographics, socioeconomic status, admission vital signs, and related comorbidities. Statistical interactions between malnutrition and patient age were significant in both the pediatric [log-odds and 95% confidence interval: 0.094 (0.012, 0.175)] and adult [− 0.014 (− 0.021, − 0.006] models. These interactions, together with the main effect terms of malnutrition and age, imply higher odds for severe COVID-19 for children between 6 and 17 years with history of malnutrition. Even higher odds of severe COVID-19 exist for adults (with history of malnutrition) between 18 and 79 years. These results indicate that the long-term effect of malnutrition predisposes patients to severe COVID-19 in an age-dependent way. |
| first_indexed | 2024-12-14T15:35:01Z |
| format | Article |
| id | doaj.art-d42c0cbee56c4b90898013ab6a206eb6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T15:35:01Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d42c0cbee56c4b90898013ab6a206eb62022-12-21T22:55:46ZengNature PortfolioScientific Reports2045-23222021-07-011111810.1038/s41598-021-94138-zLong-term effects of malnutrition on severity of COVID-19Alec Kurtz0Kenneth Grant1Rachel Marano2Antonio Arrieta3Kenneth Grant4William Feaster5Caroline Steele6Louis Ehwerhemuepha7Albany Medical CollegeChildren’s Hospital of Orange CountyChildren’s Hospital of Orange CountyChildren’s Hospital of Orange CountyAlbany Medical CollegeChildren’s Hospital of Orange CountyChildren’s Hospital of Orange CountyChildren’s Hospital of Orange CountyAbstract The COVID-19 pandemic is a public health crisis that has the potential to exacerbate worldwide malnutrition. This study examines whether patients with a history of malnutrition are predisposed to severe COVID-19. To do so, data on 103,099 COVID-19 inpatient encounters from 56 hospitals in the United States between March 2020 and June 2020 were retrieved from the Cerner COVID-19 Dataset. Patients with a history of malnutrition between 2015 and 2019 were identified, and a random intercept logistic regression models for pediatric and adult patients were built controlling for patient demographics, socioeconomic status, admission vital signs, and related comorbidities. Statistical interactions between malnutrition and patient age were significant in both the pediatric [log-odds and 95% confidence interval: 0.094 (0.012, 0.175)] and adult [− 0.014 (− 0.021, − 0.006] models. These interactions, together with the main effect terms of malnutrition and age, imply higher odds for severe COVID-19 for children between 6 and 17 years with history of malnutrition. Even higher odds of severe COVID-19 exist for adults (with history of malnutrition) between 18 and 79 years. These results indicate that the long-term effect of malnutrition predisposes patients to severe COVID-19 in an age-dependent way.https://doi.org/10.1038/s41598-021-94138-z |
| spellingShingle | Alec Kurtz Kenneth Grant Rachel Marano Antonio Arrieta Kenneth Grant William Feaster Caroline Steele Louis Ehwerhemuepha Long-term effects of malnutrition on severity of COVID-19 Scientific Reports |
| title | Long-term effects of malnutrition on severity of COVID-19 |
| title_full | Long-term effects of malnutrition on severity of COVID-19 |
| title_fullStr | Long-term effects of malnutrition on severity of COVID-19 |
| title_full_unstemmed | Long-term effects of malnutrition on severity of COVID-19 |
| title_short | Long-term effects of malnutrition on severity of COVID-19 |
| title_sort | long term effects of malnutrition on severity of covid 19 |
| url | https://doi.org/10.1038/s41598-021-94138-z |
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