Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia
BackgroundRecent studies have discovered that α‐globin is expressed in blood vessel walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood pressure (BP) might differ between normal individuals and those with α+thalassemia, in whom the production of α‐globin is r...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-04-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.117.005613 |
| _version_ | 1819178211353821184 |
|---|---|
| author | Anthony O. Etyang Christopher Khayeka‐Wandabwa Sailoki Kapesa Esther Muthumbi Emily Odipo Marylene Wamukoya Nicholas Ngomi Tilahun Haregu Catherine Kyobutungi Metrine Tendwa Johnstone Makale Alex Macharia J. Kennedy Cruickshank Liam Smeeth J. Anthony G. Scott Thomas N. Williams |
| author_facet | Anthony O. Etyang Christopher Khayeka‐Wandabwa Sailoki Kapesa Esther Muthumbi Emily Odipo Marylene Wamukoya Nicholas Ngomi Tilahun Haregu Catherine Kyobutungi Metrine Tendwa Johnstone Makale Alex Macharia J. Kennedy Cruickshank Liam Smeeth J. Anthony G. Scott Thomas N. Williams |
| author_sort | Anthony O. Etyang |
| collection | DOAJ |
| description | BackgroundRecent studies have discovered that α‐globin is expressed in blood vessel walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood pressure (BP) might differ between normal individuals and those with α+thalassemia, in whom the production of α‐globin is reduced. Methods and ResultsThe study was conducted in Nairobi, Kenya, among 938 adolescents aged 11 to 17 years. Twenty‐four‐hour ambulatory BP monitoring and arterial stiffness measurements were performed using an arteriograph device. We genotyped for α+thalassemia by polymerase chain reaction. Complete data for analysis were available for 623 subjects; 223 (36%) were heterozygous (−α/αα) and 47 (8%) were homozygous (−α/−α) for α+thalassemia whereas the remaining 353 (55%) were normal (αα/αα). Mean 24‐hour systolic BP ±SD was 118±12 mm Hg in αα/αα, 117±11 mm Hg in −α/αα, and 118±11 mm Hg in −α/−α subjects, respectively. Mean 24‐hour diastolic BP ±SD in these groups was 64±8, 63±7, and 65±8 mm Hg, respectively. Mean pulse wave velocity (PWV)±SD was 7±0.8, 7±0.8, and 7±0.7 ms−1, respectively. No differences were observed in PWV and any of the 24‐hour ambulatory BP monitoring‐derived measures between those with and without α+thalassemia. ConclusionsThese data suggest that the presence of α+thalassemia does not affect BP and/or arterial stiffness in Kenyan adolescents. |
| first_indexed | 2024-12-22T21:38:57Z |
| format | Article |
| id | doaj.art-d42d8beadc204f8f8ea9496cf8e4f754 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-22T21:38:57Z |
| publishDate | 2017-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-d42d8beadc204f8f8ea9496cf8e4f7542022-12-21T18:11:39ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802017-04-016410.1161/JAHA.117.005613Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+ThalassemiaAnthony O. Etyang0Christopher Khayeka‐Wandabwa1Sailoki Kapesa2Esther Muthumbi3Emily Odipo4Marylene Wamukoya5Nicholas Ngomi6Tilahun Haregu7Catherine Kyobutungi8Metrine Tendwa9Johnstone Makale10Alex Macharia11J. Kennedy Cruickshank12Liam Smeeth13J. Anthony G. Scott14Thomas N. Williams15KEMRI‐Wellcome Trust Research Program, Kilifi, KenyaAfrican Population and Health Research Centre, Nairobi, KenyaKEMRI‐Wellcome Trust Research Program, Kilifi, KenyaKEMRI‐Wellcome Trust Research Program, Kilifi, KenyaKEMRI‐Wellcome Trust Research Program, Kilifi, KenyaAfrican Population and Health Research Centre, Nairobi, KenyaAfrican Population and Health Research Centre, Nairobi, KenyaAfrican Population and Health Research Centre, Nairobi, KenyaAfrican Population and Health Research Centre, Nairobi, KenyaKEMRI‐Wellcome Trust Research Program, Kilifi, KenyaKEMRI‐Wellcome Trust Research Program, Kilifi, KenyaKEMRI‐Wellcome Trust Research Program, Kilifi, KenyaKing's College, London, United KingdomLondon School of Hygiene and Tropical Medicine, London, United KingdomKEMRI‐Wellcome Trust Research Program, Kilifi, KenyaKEMRI‐Wellcome Trust Research Program, Kilifi, KenyaBackgroundRecent studies have discovered that α‐globin is expressed in blood vessel walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood pressure (BP) might differ between normal individuals and those with α+thalassemia, in whom the production of α‐globin is reduced. Methods and ResultsThe study was conducted in Nairobi, Kenya, among 938 adolescents aged 11 to 17 years. Twenty‐four‐hour ambulatory BP monitoring and arterial stiffness measurements were performed using an arteriograph device. We genotyped for α+thalassemia by polymerase chain reaction. Complete data for analysis were available for 623 subjects; 223 (36%) were heterozygous (−α/αα) and 47 (8%) were homozygous (−α/−α) for α+thalassemia whereas the remaining 353 (55%) were normal (αα/αα). Mean 24‐hour systolic BP ±SD was 118±12 mm Hg in αα/αα, 117±11 mm Hg in −α/αα, and 118±11 mm Hg in −α/−α subjects, respectively. Mean 24‐hour diastolic BP ±SD in these groups was 64±8, 63±7, and 65±8 mm Hg, respectively. Mean pulse wave velocity (PWV)±SD was 7±0.8, 7±0.8, and 7±0.7 ms−1, respectively. No differences were observed in PWV and any of the 24‐hour ambulatory BP monitoring‐derived measures between those with and without α+thalassemia. ConclusionsThese data suggest that the presence of α+thalassemia does not affect BP and/or arterial stiffness in Kenyan adolescents.https://www.ahajournals.org/doi/10.1161/JAHA.117.005613adolescenceambulatory blood pressure monitoringα+thalassemia |
| spellingShingle | Anthony O. Etyang Christopher Khayeka‐Wandabwa Sailoki Kapesa Esther Muthumbi Emily Odipo Marylene Wamukoya Nicholas Ngomi Tilahun Haregu Catherine Kyobutungi Metrine Tendwa Johnstone Makale Alex Macharia J. Kennedy Cruickshank Liam Smeeth J. Anthony G. Scott Thomas N. Williams Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease adolescence ambulatory blood pressure monitoring α+thalassemia |
| title | Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia |
| title_full | Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia |
| title_fullStr | Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia |
| title_full_unstemmed | Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia |
| title_short | Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia |
| title_sort | blood pressure and arterial stiffness in kenyan adolescents with α thalassemia |
| topic | adolescence ambulatory blood pressure monitoring α+thalassemia |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.117.005613 |
| work_keys_str_mv | AT anthonyoetyang bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT christopherkhayekawandabwa bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT sailokikapesa bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT esthermuthumbi bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT emilyodipo bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT marylenewamukoya bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT nicholasngomi bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT tilahunharegu bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT catherinekyobutungi bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT metrinetendwa bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT johnstonemakale bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT alexmacharia bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT jkennedycruickshank bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT liamsmeeth bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT janthonygscott bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia AT thomasnwilliams bloodpressureandarterialstiffnessinkenyanadolescentswithathalassemia |