Cortactin in Lung Cell Function and Disease
Cortactin (CTTN) is an actin-binding and cytoskeletal protein that is found in abundance in the cell cortex and other peripheral structures of most cell types. It was initially described as a target for Src-mediated phosphorylation at several tyrosine sites within CTTN, and post-translational modifi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/4606 |
| _version_ | 1797504670074142720 |
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| author | Mounica Bandela Patrick Belvitch Joe G. N. Garcia Steven M. Dudek |
| author_facet | Mounica Bandela Patrick Belvitch Joe G. N. Garcia Steven M. Dudek |
| author_sort | Mounica Bandela |
| collection | DOAJ |
| description | Cortactin (CTTN) is an actin-binding and cytoskeletal protein that is found in abundance in the cell cortex and other peripheral structures of most cell types. It was initially described as a target for Src-mediated phosphorylation at several tyrosine sites within CTTN, and post-translational modifications at these tyrosine sites are a primary regulator of its function. CTTN participates in multiple cellular functions that require cytoskeletal rearrangement, including lamellipodia formation, cell migration, invasion, and various other processes dependent upon the cell type involved. The role of CTTN in vascular endothelial cells is particularly important for promoting barrier integrity and inhibiting vascular permeability and tissue edema. To mediate its functional effects, CTTN undergoes multiple post-translational modifications and interacts with numerous other proteins to alter cytoskeletal structures and signaling mechanisms. In the present review, we briefly describe CTTN structure, post-translational modifications, and protein binding partners and then focus on its role in regulating cellular processes and well-established functional mechanisms, primarily in vascular endothelial cells and disease models. We then provide insights into how CTTN function affects the pathophysiology of multiple lung disorders, including acute lung injury syndromes, COPD, and asthma. |
| first_indexed | 2024-03-10T04:07:37Z |
| format | Article |
| id | doaj.art-d42f5c9da1fb4d54a303242ff6760a89 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:07:37Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d42f5c9da1fb4d54a303242ff6760a892023-11-23T08:19:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01239460610.3390/ijms23094606Cortactin in Lung Cell Function and DiseaseMounica Bandela0Patrick Belvitch1Joe G. N. Garcia2Steven M. Dudek3Department of Biomedical Engineering, College of Engineering, University of Illinois at Chicago, Chicago, IL 60607, USADivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USADepartment of Medicine, University of Arizona, Tucson, AZ 85721, USADivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USACortactin (CTTN) is an actin-binding and cytoskeletal protein that is found in abundance in the cell cortex and other peripheral structures of most cell types. It was initially described as a target for Src-mediated phosphorylation at several tyrosine sites within CTTN, and post-translational modifications at these tyrosine sites are a primary regulator of its function. CTTN participates in multiple cellular functions that require cytoskeletal rearrangement, including lamellipodia formation, cell migration, invasion, and various other processes dependent upon the cell type involved. The role of CTTN in vascular endothelial cells is particularly important for promoting barrier integrity and inhibiting vascular permeability and tissue edema. To mediate its functional effects, CTTN undergoes multiple post-translational modifications and interacts with numerous other proteins to alter cytoskeletal structures and signaling mechanisms. In the present review, we briefly describe CTTN structure, post-translational modifications, and protein binding partners and then focus on its role in regulating cellular processes and well-established functional mechanisms, primarily in vascular endothelial cells and disease models. We then provide insights into how CTTN function affects the pathophysiology of multiple lung disorders, including acute lung injury syndromes, COPD, and asthma.https://www.mdpi.com/1422-0067/23/9/4606cortactinendotheliumactin cytoskeletonARDSCOPDasthma |
| spellingShingle | Mounica Bandela Patrick Belvitch Joe G. N. Garcia Steven M. Dudek Cortactin in Lung Cell Function and Disease International Journal of Molecular Sciences cortactin endothelium actin cytoskeleton ARDS COPD asthma |
| title | Cortactin in Lung Cell Function and Disease |
| title_full | Cortactin in Lung Cell Function and Disease |
| title_fullStr | Cortactin in Lung Cell Function and Disease |
| title_full_unstemmed | Cortactin in Lung Cell Function and Disease |
| title_short | Cortactin in Lung Cell Function and Disease |
| title_sort | cortactin in lung cell function and disease |
| topic | cortactin endothelium actin cytoskeleton ARDS COPD asthma |
| url | https://www.mdpi.com/1422-0067/23/9/4606 |
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