Within amygdala: Basolateral parts are selectively impaired in premature-born adults
While it is known that whole amygdala volume is lastingly reduced after premature birth, it is unknown whether different amygdala nuclei are distinctively affected by prematurity. This question is motivated by two points: First, the observation that developmental trajectories of superficial, centrom...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
|
| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158221002242 |
| _version_ | 1818880883791233024 |
|---|---|
| author | Benita Schmitz-Koep Juliana Zimmermann Aurore Menegaux Rachel Nuttall Josef G. Bäuml Sebastian C. Schneider Marcel Daamen Henning Boecker Claus Zimmer Dieter Wolke Peter Bartmann Dennis M. Hedderich Christian Sorg |
| author_facet | Benita Schmitz-Koep Juliana Zimmermann Aurore Menegaux Rachel Nuttall Josef G. Bäuml Sebastian C. Schneider Marcel Daamen Henning Boecker Claus Zimmer Dieter Wolke Peter Bartmann Dennis M. Hedderich Christian Sorg |
| author_sort | Benita Schmitz-Koep |
| collection | DOAJ |
| description | While it is known that whole amygdala volume is lastingly reduced after premature birth, it is unknown whether different amygdala nuclei are distinctively affected by prematurity. This question is motivated by two points: First, the observation that developmental trajectories of superficial, centromedial and basolateral amygdala nuclei are different. And second, the expectation that these different developmental pathways are distinctively affected by prematurity. Furthermore, we stated the question whether alterations in amygdala nuclei are associated with increased adults’ anxiety traits after premature birth.We investigated 101 very premature-born adults (<32 weeks of gestation and/or birth weight below 1500 g) and 108 full-term controls of a prospectively and longitudinally collected cohort at 26 years of age using automated amygdala nuclei segmentation based on structural MRI.We found selectively reduced volumes of bilateral accessory basal nuclei (pertaining to the basolateral amygdala of claustral developmental trajectory) adjusted for whole amygdala volume. Volumes of bilateral accessory basal nuclei were positively associated with gestational age and negatively associated with duration of ventilation. Furthermore, structural covariance within the basolateral amygdala was increased in premature-born adults. We did not find an association between reduced volumes of basolateral amygdala and increased social anxiety in the prematurity group.These results demonstrate specifically altered basolateral amygdala structure in premature-born adults. Data suggest that prematurity has distinct effects on amygdala nuclei. |
| first_indexed | 2024-12-19T14:53:03Z |
| format | Article |
| id | doaj.art-d430db7057d94061aed31d500e865e82 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-19T14:53:03Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-d430db7057d94061aed31d500e865e822022-12-21T20:16:47ZengElsevierNeuroImage: Clinical2213-15822021-01-0131102780Within amygdala: Basolateral parts are selectively impaired in premature-born adultsBenita Schmitz-Koep0Juliana Zimmermann1Aurore Menegaux2Rachel Nuttall3Josef G. Bäuml4Sebastian C. Schneider5Marcel Daamen6Henning Boecker7Claus Zimmer8Dieter Wolke9Peter Bartmann10Dennis M. Hedderich11Christian Sorg12Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, Germany; TUM-NIC Neuroimaging Center, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, Germany; Corresponding author at: Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, Germany.Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, Germany; TUM-NIC Neuroimaging Center, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, Germany; TUM-NIC Neuroimaging Center, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, Germany; TUM-NIC Neuroimaging Center, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, Germany; TUM-NIC Neuroimaging Center, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, Germany; TUM-NIC Neuroimaging Center, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, GermanyFunctional Neuroimaging Group, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany; Department of Neonatology, University Hospital Bonn, Venusberg-Campus 1, Bonn, GermanyFunctional Neuroimaging Group, Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, Bonn, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, Germany; TUM-NIC Neuroimaging Center, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, GermanyDepartment of Psychology, University of Warwick, University Road, Coventry CV4 7AL, United Kingdom; Warwick Medical School, University of Warwick, University Road, Coventry CV4 7AL, United KingdomDepartment of Neonatology, University Hospital Bonn, Venusberg-Campus 1, Bonn, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, Germany; TUM-NIC Neuroimaging Center, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, Germany; TUM-NIC Neuroimaging Center, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, Germany; Department of Psychiatry, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich 81675, GermanyWhile it is known that whole amygdala volume is lastingly reduced after premature birth, it is unknown whether different amygdala nuclei are distinctively affected by prematurity. This question is motivated by two points: First, the observation that developmental trajectories of superficial, centromedial and basolateral amygdala nuclei are different. And second, the expectation that these different developmental pathways are distinctively affected by prematurity. Furthermore, we stated the question whether alterations in amygdala nuclei are associated with increased adults’ anxiety traits after premature birth.We investigated 101 very premature-born adults (<32 weeks of gestation and/or birth weight below 1500 g) and 108 full-term controls of a prospectively and longitudinally collected cohort at 26 years of age using automated amygdala nuclei segmentation based on structural MRI.We found selectively reduced volumes of bilateral accessory basal nuclei (pertaining to the basolateral amygdala of claustral developmental trajectory) adjusted for whole amygdala volume. Volumes of bilateral accessory basal nuclei were positively associated with gestational age and negatively associated with duration of ventilation. Furthermore, structural covariance within the basolateral amygdala was increased in premature-born adults. We did not find an association between reduced volumes of basolateral amygdala and increased social anxiety in the prematurity group.These results demonstrate specifically altered basolateral amygdala structure in premature-born adults. Data suggest that prematurity has distinct effects on amygdala nuclei.http://www.sciencedirect.com/science/article/pii/S2213158221002242Premature birthHumanBrain developmentAmygdala nucleiBasolateral amygdalaStructural magnetic resonance imaging |
| spellingShingle | Benita Schmitz-Koep Juliana Zimmermann Aurore Menegaux Rachel Nuttall Josef G. Bäuml Sebastian C. Schneider Marcel Daamen Henning Boecker Claus Zimmer Dieter Wolke Peter Bartmann Dennis M. Hedderich Christian Sorg Within amygdala: Basolateral parts are selectively impaired in premature-born adults NeuroImage: Clinical Premature birth Human Brain development Amygdala nuclei Basolateral amygdala Structural magnetic resonance imaging |
| title | Within amygdala: Basolateral parts are selectively impaired in premature-born adults |
| title_full | Within amygdala: Basolateral parts are selectively impaired in premature-born adults |
| title_fullStr | Within amygdala: Basolateral parts are selectively impaired in premature-born adults |
| title_full_unstemmed | Within amygdala: Basolateral parts are selectively impaired in premature-born adults |
| title_short | Within amygdala: Basolateral parts are selectively impaired in premature-born adults |
| title_sort | within amygdala basolateral parts are selectively impaired in premature born adults |
| topic | Premature birth Human Brain development Amygdala nuclei Basolateral amygdala Structural magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2213158221002242 |
| work_keys_str_mv | AT benitaschmitzkoep withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults AT julianazimmermann withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults AT auroremenegaux withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults AT rachelnuttall withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults AT josefgbauml withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults AT sebastiancschneider withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults AT marceldaamen withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults AT henningboecker withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults AT clauszimmer withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults AT dieterwolke withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults AT peterbartmann withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults AT dennismhedderich withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults AT christiansorg withinamygdalabasolateralpartsareselectivelyimpairedinprematurebornadults |