Antifungal Activity of Essential Oil and Plant-Derived Natural Compounds against <i>Aspergillus flavus</i>
<i>Aspergillus flavus</i> is a facultative parasite that contaminates several important food crops at both the pre- and post-harvest stages. Moreover, it is an opportunistic animal and human pathogen that causes aspergillosis diseases. <i>A. flavus</i> also produces the polyk...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/12/1727 |
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| author | Fei Tian So Young Woo Sang Yoo Lee Su Been Park Yaxin Zheng Hyang Sook Chun |
| author_facet | Fei Tian So Young Woo Sang Yoo Lee Su Been Park Yaxin Zheng Hyang Sook Chun |
| author_sort | Fei Tian |
| collection | DOAJ |
| description | <i>Aspergillus flavus</i> is a facultative parasite that contaminates several important food crops at both the pre- and post-harvest stages. Moreover, it is an opportunistic animal and human pathogen that causes aspergillosis diseases. <i>A. flavus</i> also produces the polyketide-derived carcinogenic and mutagenic secondary metabolite aflatoxin, which negatively impacts global food security and threatens human and livestock health. Recently, plant-derived natural compounds and essential oils (EOs) have shown great potential in combatting <i>A. flavus</i> spoilage and aflatoxin contamination. In this review, the in situ antifungal and antiaflatoxigenic properties of EOs are discussed. The mechanisms through which EOs affect <i>A. flavus</i> growth and aflatoxin biosynthesis are then reviewed. Indeed, several involve physical, chemical, or biochemical changes to the cell wall, cell membrane, mitochondria, and related metabolic enzymes and genes. Finally, the future perspectives towards the application of plant-derived natural compounds and EOs in food protection and novel antifungal agent development are discussed. The present review highlights the great potential of plant-derived natural compounds and EOs to protect agricultural commodities and food items from <i>A. flavus</i> spoilage and aflatoxin contamination, along with reducing the threat of aspergillosis diseases. |
| first_indexed | 2024-03-09T17:24:27Z |
| format | Article |
| id | doaj.art-d432e121899d4aeb80d45688ae1d33ce |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T17:24:27Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-d432e121899d4aeb80d45688ae1d33ce2023-11-24T12:53:20ZengMDPI AGAntibiotics2079-63822022-12-011112172710.3390/antibiotics11121727Antifungal Activity of Essential Oil and Plant-Derived Natural Compounds against <i>Aspergillus flavus</i>Fei Tian0So Young Woo1Sang Yoo Lee2Su Been Park3Yaxin Zheng4Hyang Sook Chun5Food Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong 17546, Republic of KoreaFood Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong 17546, Republic of KoreaFood Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong 17546, Republic of KoreaFood Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong 17546, Republic of KoreaFood Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong 17546, Republic of KoreaFood Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea<i>Aspergillus flavus</i> is a facultative parasite that contaminates several important food crops at both the pre- and post-harvest stages. Moreover, it is an opportunistic animal and human pathogen that causes aspergillosis diseases. <i>A. flavus</i> also produces the polyketide-derived carcinogenic and mutagenic secondary metabolite aflatoxin, which negatively impacts global food security and threatens human and livestock health. Recently, plant-derived natural compounds and essential oils (EOs) have shown great potential in combatting <i>A. flavus</i> spoilage and aflatoxin contamination. In this review, the in situ antifungal and antiaflatoxigenic properties of EOs are discussed. The mechanisms through which EOs affect <i>A. flavus</i> growth and aflatoxin biosynthesis are then reviewed. Indeed, several involve physical, chemical, or biochemical changes to the cell wall, cell membrane, mitochondria, and related metabolic enzymes and genes. Finally, the future perspectives towards the application of plant-derived natural compounds and EOs in food protection and novel antifungal agent development are discussed. The present review highlights the great potential of plant-derived natural compounds and EOs to protect agricultural commodities and food items from <i>A. flavus</i> spoilage and aflatoxin contamination, along with reducing the threat of aspergillosis diseases.https://www.mdpi.com/2079-6382/11/12/1727natural compoundsessential oilantifungal agent<i>Aspergillus flavus</i>aflatoxinmechanism of action |
| spellingShingle | Fei Tian So Young Woo Sang Yoo Lee Su Been Park Yaxin Zheng Hyang Sook Chun Antifungal Activity of Essential Oil and Plant-Derived Natural Compounds against <i>Aspergillus flavus</i> Antibiotics natural compounds essential oil antifungal agent <i>Aspergillus flavus</i> aflatoxin mechanism of action |
| title | Antifungal Activity of Essential Oil and Plant-Derived Natural Compounds against <i>Aspergillus flavus</i> |
| title_full | Antifungal Activity of Essential Oil and Plant-Derived Natural Compounds against <i>Aspergillus flavus</i> |
| title_fullStr | Antifungal Activity of Essential Oil and Plant-Derived Natural Compounds against <i>Aspergillus flavus</i> |
| title_full_unstemmed | Antifungal Activity of Essential Oil and Plant-Derived Natural Compounds against <i>Aspergillus flavus</i> |
| title_short | Antifungal Activity of Essential Oil and Plant-Derived Natural Compounds against <i>Aspergillus flavus</i> |
| title_sort | antifungal activity of essential oil and plant derived natural compounds against i aspergillus flavus i |
| topic | natural compounds essential oil antifungal agent <i>Aspergillus flavus</i> aflatoxin mechanism of action |
| url | https://www.mdpi.com/2079-6382/11/12/1727 |
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