Review of Animal Models to Study Pulp Inflammation
Human dental pulp is a highly dynamic tissue equipped with a network of resident immunocompetent cells that play a major role in the defense against pathogens and during tissue injury. Animal studies are mandatory and complementary to in vitro experiments when studying the physiopathology of dental...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Dental Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2021.673552/full |
| _version_ | 1818607391873171456 |
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| author | Davy Aubeux Davy Aubeux Davy Aubeux Emmanuelle Renard Emmanuelle Renard Emmanuelle Renard Fabienne Pérez Fabienne Pérez Fabienne Pérez Solène Tessier Solène Tessier Valérie Geoffroy Valérie Geoffroy Alexis Gaudin Alexis Gaudin Alexis Gaudin |
| author_facet | Davy Aubeux Davy Aubeux Davy Aubeux Emmanuelle Renard Emmanuelle Renard Emmanuelle Renard Fabienne Pérez Fabienne Pérez Fabienne Pérez Solène Tessier Solène Tessier Valérie Geoffroy Valérie Geoffroy Alexis Gaudin Alexis Gaudin Alexis Gaudin |
| author_sort | Davy Aubeux |
| collection | DOAJ |
| description | Human dental pulp is a highly dynamic tissue equipped with a network of resident immunocompetent cells that play a major role in the defense against pathogens and during tissue injury. Animal studies are mandatory and complementary to in vitro experiments when studying the physiopathology of dental pulp, new diagnostic tools, or innovative therapeutic strategies. This animal approach makes it possible to define a benefit-risk ratio necessary to be subsequently tested in humans. Among the animal kingdom, rodents, rabbits, ferrets, swine, dogs, and non-human primates have been used to model human pulpitis. The diversity of animals found in studies indicate the difficulty of choosing the correct and most efficient model. Each animal model has its own characteristics that may be advantageous or limiting, according to the studied parameters. These elements have to be considered in preclinical studies. This article aims to provide a thorough understanding of the different animal models used to study pulp inflammation. This may help to find the most pertinent or appropriate animal model depending on the hypothesis investigated and the expected results. |
| first_indexed | 2024-12-16T14:26:01Z |
| format | Article |
| id | doaj.art-d433f9c0d7cf4501b09a3583395e1a30 |
| institution | Directory Open Access Journal |
| issn | 2673-4915 |
| language | English |
| last_indexed | 2024-12-16T14:26:01Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Dental Medicine |
| spelling | doaj.art-d433f9c0d7cf4501b09a3583395e1a302022-12-21T22:28:22ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152021-05-01210.3389/fdmed.2021.673552673552Review of Animal Models to Study Pulp InflammationDavy Aubeux0Davy Aubeux1Davy Aubeux2Emmanuelle Renard3Emmanuelle Renard4Emmanuelle Renard5Fabienne Pérez6Fabienne Pérez7Fabienne Pérez8Solène Tessier9Solène Tessier10Valérie Geoffroy11Valérie Geoffroy12Alexis Gaudin13Alexis Gaudin14Alexis Gaudin15Inserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, École nationale vétérinaire, agroalimentaire et de l'alimentation de Nantes Atlantique (ONIRIS), Nantes, FranceUnité Formation Recherche (UFR) Odontologie, Université de Nantes, Nantes, FrancePôle Hospitalo-Universitaire 4 Ostéo-Articulaire - Tête et Cou - Odontologie - Neurochirurgie - Neuro-Traumatologie - Uca (PHU4 OTONN), Centre Hospitalo-Universitaire (CHU) Nantes, Nantes, FranceInserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, École nationale vétérinaire, agroalimentaire et de l'alimentation de Nantes Atlantique (ONIRIS), Nantes, FranceUnité Formation Recherche (UFR) Odontologie, Université de Nantes, Nantes, FrancePôle Hospitalo-Universitaire 4 Ostéo-Articulaire - Tête et Cou - Odontologie - Neurochirurgie - Neuro-Traumatologie - Uca (PHU4 OTONN), Centre Hospitalo-Universitaire (CHU) Nantes, Nantes, FranceInserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, École nationale vétérinaire, agroalimentaire et de l'alimentation de Nantes Atlantique (ONIRIS), Nantes, FranceUnité Formation Recherche (UFR) Odontologie, Université de Nantes, Nantes, FrancePôle Hospitalo-Universitaire 4 Ostéo-Articulaire - Tête et Cou - Odontologie - Neurochirurgie - Neuro-Traumatologie - Uca (PHU4 OTONN), Centre Hospitalo-Universitaire (CHU) Nantes, Nantes, FranceInserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, École nationale vétérinaire, agroalimentaire et de l'alimentation de Nantes Atlantique (ONIRIS), Nantes, FranceUnité Formation Recherche (UFR) Odontologie, Université de Nantes, Nantes, FranceInserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, École nationale vétérinaire, agroalimentaire et de l'alimentation de Nantes Atlantique (ONIRIS), Nantes, FranceUnité Formation Recherche (UFR) Odontologie, Université de Nantes, Nantes, FranceInserm, UMR 1229, RMeS, Regenerative Medicine and Skeleton, Université de Nantes, École nationale vétérinaire, agroalimentaire et de l'alimentation de Nantes Atlantique (ONIRIS), Nantes, FranceUnité Formation Recherche (UFR) Odontologie, Université de Nantes, Nantes, FrancePôle Hospitalo-Universitaire 4 Ostéo-Articulaire - Tête et Cou - Odontologie - Neurochirurgie - Neuro-Traumatologie - Uca (PHU4 OTONN), Centre Hospitalo-Universitaire (CHU) Nantes, Nantes, FranceHuman dental pulp is a highly dynamic tissue equipped with a network of resident immunocompetent cells that play a major role in the defense against pathogens and during tissue injury. Animal studies are mandatory and complementary to in vitro experiments when studying the physiopathology of dental pulp, new diagnostic tools, or innovative therapeutic strategies. This animal approach makes it possible to define a benefit-risk ratio necessary to be subsequently tested in humans. Among the animal kingdom, rodents, rabbits, ferrets, swine, dogs, and non-human primates have been used to model human pulpitis. The diversity of animals found in studies indicate the difficulty of choosing the correct and most efficient model. Each animal model has its own characteristics that may be advantageous or limiting, according to the studied parameters. These elements have to be considered in preclinical studies. This article aims to provide a thorough understanding of the different animal models used to study pulp inflammation. This may help to find the most pertinent or appropriate animal model depending on the hypothesis investigated and the expected results.https://www.frontiersin.org/articles/10.3389/fdmed.2021.673552/fullpulpitisanimal researchanimal modelslipopolysaccharidedental pulp |
| spellingShingle | Davy Aubeux Davy Aubeux Davy Aubeux Emmanuelle Renard Emmanuelle Renard Emmanuelle Renard Fabienne Pérez Fabienne Pérez Fabienne Pérez Solène Tessier Solène Tessier Valérie Geoffroy Valérie Geoffroy Alexis Gaudin Alexis Gaudin Alexis Gaudin Review of Animal Models to Study Pulp Inflammation Frontiers in Dental Medicine pulpitis animal research animal models lipopolysaccharide dental pulp |
| title | Review of Animal Models to Study Pulp Inflammation |
| title_full | Review of Animal Models to Study Pulp Inflammation |
| title_fullStr | Review of Animal Models to Study Pulp Inflammation |
| title_full_unstemmed | Review of Animal Models to Study Pulp Inflammation |
| title_short | Review of Animal Models to Study Pulp Inflammation |
| title_sort | review of animal models to study pulp inflammation |
| topic | pulpitis animal research animal models lipopolysaccharide dental pulp |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2021.673552/full |
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