Multicellular Bioprinting of Biomimetic Inks for Tendon‐to‐Bone Regeneration
Abstract Tendon‐to‐bone interface has a hierarchical structure and gradient component that are conducive to distributing the stresses to achieve movement. Conventional biomaterials lack the capacity to induce synchronous repair of multiple tissues, resulting in the failure of the interface repair. B...
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202301309 |
| _version_ | 1827891521345552384 |
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| author | Lin Du Chen Qin Hongjian Zhang Fei Han Jianmin Xue Yufeng Wang Jinfu Wu Yin Xiao Zhiguang Huan Chengtie Wu |
| author_facet | Lin Du Chen Qin Hongjian Zhang Fei Han Jianmin Xue Yufeng Wang Jinfu Wu Yin Xiao Zhiguang Huan Chengtie Wu |
| author_sort | Lin Du |
| collection | DOAJ |
| description | Abstract Tendon‐to‐bone interface has a hierarchical structure and gradient component that are conducive to distributing the stresses to achieve movement. Conventional biomaterials lack the capacity to induce synchronous repair of multiple tissues, resulting in the failure of the interface repair. Biomimetic strategies have attracted enormous attention in the field of complex structure regeneration because they can meet the different physiological requirements of multiple tissues. Herein, a biomimetic ink mimicking tendon/bone tissues is developed by combining tendon/bone‐related cells and Mo‐containing silicate (MS) bioceramics. Subsequently, biomimetic multicellular scaffolds are fabricated to achieve the simulation of the hierarchical structure and cellular composition of tendon‐to‐bone interfaces by the spatial distribution of the biomimetic inks via 3D bioprinting, which is of great significance for inducing the regeneration of complex structures in the interface region. In addition, attributed to the desirable ionic microenvironment created by MS bioceramics, the biomimetic scaffolds possess the dual function of inducing tendon/bone‐related cells tenogenic and osteogenic differentiation in vitro, and promote the integrated regeneration of tendon‐to‐bone interfaces in vivo. The study offers a feasible strategy to construct biomimetic multicellular scaffolds with bifunction for inducing multi‐lineage tissue regeneration, especially for regenerating soft‐to‐hard tissue interfaces. |
| first_indexed | 2024-03-12T21:27:01Z |
| format | Article |
| id | doaj.art-d434ec113b1a43e3a8a08056c1677a45 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-12T21:27:01Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-d434ec113b1a43e3a8a08056c1677a452023-07-28T06:53:01ZengWileyAdvanced Science2198-38442023-07-011021n/an/a10.1002/advs.202301309Multicellular Bioprinting of Biomimetic Inks for Tendon‐to‐Bone RegenerationLin Du0Chen Qin1Hongjian Zhang2Fei Han3Jianmin Xue4Yufeng Wang5Jinfu Wu6Yin Xiao7Zhiguang Huan8Chengtie Wu9State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. ChinaNanjing First Hospital Nanjing Medical University 68th Changle Road Nanjing Jiangsu 210006 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. ChinaSchool of Medicine and Dentistry Menzies Health Institute Queensland Griffith University Queensland 4222 AustraliaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. ChinaAbstract Tendon‐to‐bone interface has a hierarchical structure and gradient component that are conducive to distributing the stresses to achieve movement. Conventional biomaterials lack the capacity to induce synchronous repair of multiple tissues, resulting in the failure of the interface repair. Biomimetic strategies have attracted enormous attention in the field of complex structure regeneration because they can meet the different physiological requirements of multiple tissues. Herein, a biomimetic ink mimicking tendon/bone tissues is developed by combining tendon/bone‐related cells and Mo‐containing silicate (MS) bioceramics. Subsequently, biomimetic multicellular scaffolds are fabricated to achieve the simulation of the hierarchical structure and cellular composition of tendon‐to‐bone interfaces by the spatial distribution of the biomimetic inks via 3D bioprinting, which is of great significance for inducing the regeneration of complex structures in the interface region. In addition, attributed to the desirable ionic microenvironment created by MS bioceramics, the biomimetic scaffolds possess the dual function of inducing tendon/bone‐related cells tenogenic and osteogenic differentiation in vitro, and promote the integrated regeneration of tendon‐to‐bone interfaces in vivo. The study offers a feasible strategy to construct biomimetic multicellular scaffolds with bifunction for inducing multi‐lineage tissue regeneration, especially for regenerating soft‐to‐hard tissue interfaces.https://doi.org/10.1002/advs.2023013093D bioprintingbiomaterialsbiomimetictendon‐to‐bone interface regeneration |
| spellingShingle | Lin Du Chen Qin Hongjian Zhang Fei Han Jianmin Xue Yufeng Wang Jinfu Wu Yin Xiao Zhiguang Huan Chengtie Wu Multicellular Bioprinting of Biomimetic Inks for Tendon‐to‐Bone Regeneration Advanced Science 3D bioprinting biomaterials biomimetic tendon‐to‐bone interface regeneration |
| title | Multicellular Bioprinting of Biomimetic Inks for Tendon‐to‐Bone Regeneration |
| title_full | Multicellular Bioprinting of Biomimetic Inks for Tendon‐to‐Bone Regeneration |
| title_fullStr | Multicellular Bioprinting of Biomimetic Inks for Tendon‐to‐Bone Regeneration |
| title_full_unstemmed | Multicellular Bioprinting of Biomimetic Inks for Tendon‐to‐Bone Regeneration |
| title_short | Multicellular Bioprinting of Biomimetic Inks for Tendon‐to‐Bone Regeneration |
| title_sort | multicellular bioprinting of biomimetic inks for tendon to bone regeneration |
| topic | 3D bioprinting biomaterials biomimetic tendon‐to‐bone interface regeneration |
| url | https://doi.org/10.1002/advs.202301309 |
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