Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling
Data on vitamin D status of patients with inherited ichthyosis in Europe is scarce and unspecific concerning the genetic subtype. This study determined serum levels of 25-hydroxyvitamin D3 (25(OH)D3) in 87 patients with ichthyosis; 69 patients were additionally analysed for parathyroid hormone. Vita...
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Medical Journals Sweden
2021-09-01
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Series: | Acta Dermato-Venereologica |
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https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3887
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author | Mi-Ran Kim Vinzenz Oji Frederic Valentin Heiko Traupe Jerzy-Roch Nofer Ingrid Hausser Hans Christian Hennies Katja Eckl Stefan A. Wudy Alberto Sánchez-Guijo Laura Kerschke Judith Fischer Kira Süßmuth |
author_facet | Mi-Ran Kim Vinzenz Oji Frederic Valentin Heiko Traupe Jerzy-Roch Nofer Ingrid Hausser Hans Christian Hennies Katja Eckl Stefan A. Wudy Alberto Sánchez-Guijo Laura Kerschke Judith Fischer Kira Süßmuth |
author_sort | Mi-Ran Kim |
collection | DOAJ |
description | Data on vitamin D status of patients with inherited ichthyosis in Europe is scarce and unspecific concerning the genetic subtype. This study determined serum levels of 25-hydroxyvitamin D3 (25(OH)D3) in 87 patients with ichthyosis; 69 patients were additionally analysed for parathyroid hormone. Vitamin D deficiency was pronounced in keratinopathic ichthyosis (n = 17; median 25(OH)D3: 10.5 ng/ml), harlequin ichthyosis (n = 2;7.0 ng/ml) and rare syndromic subtypes (n = 3; 7.0 ng/ml). Vitamin D levels were reduced in TG1-proficient lamellar ichthyosis (n = 15; 8.9 ng/ml), TG1-deficient lamellar ichthyosis (n = 12; 11.7 ng/ml), congenital ichthyosiform erythroderma (n = 13; 12.4 ng/ml), Netherton syndrome (n = 7; 10.7 ng/ml) and X-linked ichthyosis (n = 8; 13.9 ng/ml). In ichthyosis vulgaris 25(OH)D3 levels were higher (n = 10; 19.7 ng/ml). Parathyroid hormone was elevated in 12 patients. Low 25(OH)D3 levels were associated with high severity of scaling (p = 0.03) implicating scaling as a risk factor for vitamin D deficiency. Thus, this study supports our recent guidelines for ichthyoses, which recommend screening for and substituting of vitamin D deficiency. |
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id | doaj.art-d4365859e08147dda236502c70629500 |
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issn | 0001-5555 1651-2057 |
language | English |
last_indexed | 2024-04-11T16:19:08Z |
publishDate | 2021-09-01 |
publisher | Medical Journals Sweden |
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series | Acta Dermato-Venereologica |
spelling | doaj.art-d4365859e08147dda236502c706295002022-12-22T04:14:25ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572021-09-011019adv0054610.2340/00015555-38877031Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of ScalingMi-Ran Kim0Vinzenz OjiFrederic ValentinHeiko TraupeJerzy-Roch NoferIngrid HausserHans Christian HenniesKatja EcklStefan A. WudyAlberto Sánchez-GuijoLaura KerschkeJudith FischerKira Süßmuth Department of Dermatology, University of Münster, Münster, Germany. Data on vitamin D status of patients with inherited ichthyosis in Europe is scarce and unspecific concerning the genetic subtype. This study determined serum levels of 25-hydroxyvitamin D3 (25(OH)D3) in 87 patients with ichthyosis; 69 patients were additionally analysed for parathyroid hormone. Vitamin D deficiency was pronounced in keratinopathic ichthyosis (n = 17; median 25(OH)D3: 10.5 ng/ml), harlequin ichthyosis (n = 2;7.0 ng/ml) and rare syndromic subtypes (n = 3; 7.0 ng/ml). Vitamin D levels were reduced in TG1-proficient lamellar ichthyosis (n = 15; 8.9 ng/ml), TG1-deficient lamellar ichthyosis (n = 12; 11.7 ng/ml), congenital ichthyosiform erythroderma (n = 13; 12.4 ng/ml), Netherton syndrome (n = 7; 10.7 ng/ml) and X-linked ichthyosis (n = 8; 13.9 ng/ml). In ichthyosis vulgaris 25(OH)D3 levels were higher (n = 10; 19.7 ng/ml). Parathyroid hormone was elevated in 12 patients. Low 25(OH)D3 levels were associated with high severity of scaling (p = 0.03) implicating scaling as a risk factor for vitamin D deficiency. Thus, this study supports our recent guidelines for ichthyoses, which recommend screening for and substituting of vitamin D deficiency. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3887 ichthyosis vitamin d deficiency parathyroid hormone |
spellingShingle | Mi-Ran Kim Vinzenz Oji Frederic Valentin Heiko Traupe Jerzy-Roch Nofer Ingrid Hausser Hans Christian Hennies Katja Eckl Stefan A. Wudy Alberto Sánchez-Guijo Laura Kerschke Judith Fischer Kira Süßmuth Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling Acta Dermato-Venereologica ichthyosis vitamin d deficiency parathyroid hormone |
title | Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling |
title_full | Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling |
title_fullStr | Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling |
title_full_unstemmed | Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling |
title_short | Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling |
title_sort | vitamin d status in distinct types of ichthyosis importance of genetic type and severity of scaling |
topic | ichthyosis vitamin d deficiency parathyroid hormone |
url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3887
|
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