Pt Nanoparticles Anchored on NH<sub>2</sub>-MIL-101 with Efficient Peroxidase-Like Activity for Colorimetric Detection of Dopamine
Dopamine (DA) is an important catecholamine neurotransmitter that plays a highly relevant role in regulating the central nervous system, and abnormal DA content can cause many immune-related diseases. Hence, it is of significance to sensitively and specifically identify DA for clinical medicine. In...
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MDPI AG
2021-06-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/9/6/140 |
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| author | Jing Li Keying Xu Yang Chen Jie Zhao Peiyao Du Libing Zhang Zhen Zhang Xiaoquan Lu |
| author_facet | Jing Li Keying Xu Yang Chen Jie Zhao Peiyao Du Libing Zhang Zhen Zhang Xiaoquan Lu |
| author_sort | Jing Li |
| collection | DOAJ |
| description | Dopamine (DA) is an important catecholamine neurotransmitter that plays a highly relevant role in regulating the central nervous system, and abnormal DA content can cause many immune-related diseases. Hence, it is of significance to sensitively and specifically identify DA for clinical medicine. In this work, Pt/NH<sub>2</sub>-MIL-101 hybrid nanozymes with bimetallic catalytic centers were fabricated by forming coordinate bonds between Pt nanoparticles (Pt NPs) and –NH<sub>2</sub> on metal–organic frameworks (MOF). The catalytic activity of Pt/NH<sub>2</sub>-MIL-101 was increased by 1.5 times via enlarging the exposure of more active sites and improving the activity of the active sites through the strategy of forming bimetallic catalytic centers. In the presence of DA, competing with 3, 3′, 5, 5′-tetramethylbenzidine (TMB) for the generated hydroxyl radicals (•OH), the blue oxidation state TMB (Ox-TMB) is reduced to colorless TMB, showing dramatic color changes. The Pt/NH<sub>2</sub>-MIL-101-based colorimetric assay enables the sensitive and robust detection of DA molecules with a detection limit of only 0.42 μM and has an observable potential in clinical applications. |
| first_indexed | 2024-03-10T10:25:46Z |
| format | Article |
| id | doaj.art-d436ffbef8f1434c93cea293e9032a03 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-10T10:25:46Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-d436ffbef8f1434c93cea293e9032a032023-11-22T00:05:34ZengMDPI AGChemosensors2227-90402021-06-019614010.3390/chemosensors9060140Pt Nanoparticles Anchored on NH<sub>2</sub>-MIL-101 with Efficient Peroxidase-Like Activity for Colorimetric Detection of DopamineJing Li0Keying Xu1Yang Chen2Jie Zhao3Peiyao Du4Libing Zhang5Zhen Zhang6Xiaoquan Lu7Tianjin Key Laboratory of Molecular Optoelectronic, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory of Molecular Optoelectronic, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory of Molecular Optoelectronic, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory of Molecular Optoelectronic, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory of Molecular Optoelectronic, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory of Molecular Optoelectronic, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory of Molecular Optoelectronic, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, ChinaKey Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, ChinaDopamine (DA) is an important catecholamine neurotransmitter that plays a highly relevant role in regulating the central nervous system, and abnormal DA content can cause many immune-related diseases. Hence, it is of significance to sensitively and specifically identify DA for clinical medicine. In this work, Pt/NH<sub>2</sub>-MIL-101 hybrid nanozymes with bimetallic catalytic centers were fabricated by forming coordinate bonds between Pt nanoparticles (Pt NPs) and –NH<sub>2</sub> on metal–organic frameworks (MOF). The catalytic activity of Pt/NH<sub>2</sub>-MIL-101 was increased by 1.5 times via enlarging the exposure of more active sites and improving the activity of the active sites through the strategy of forming bimetallic catalytic centers. In the presence of DA, competing with 3, 3′, 5, 5′-tetramethylbenzidine (TMB) for the generated hydroxyl radicals (•OH), the blue oxidation state TMB (Ox-TMB) is reduced to colorless TMB, showing dramatic color changes. The Pt/NH<sub>2</sub>-MIL-101-based colorimetric assay enables the sensitive and robust detection of DA molecules with a detection limit of only 0.42 μM and has an observable potential in clinical applications.https://www.mdpi.com/2227-9040/9/6/140peroxidase-like activityPt NPsmetal–organic frameworkcolorimetricdopamine |
| spellingShingle | Jing Li Keying Xu Yang Chen Jie Zhao Peiyao Du Libing Zhang Zhen Zhang Xiaoquan Lu Pt Nanoparticles Anchored on NH<sub>2</sub>-MIL-101 with Efficient Peroxidase-Like Activity for Colorimetric Detection of Dopamine Chemosensors peroxidase-like activity Pt NPs metal–organic framework colorimetric dopamine |
| title | Pt Nanoparticles Anchored on NH<sub>2</sub>-MIL-101 with Efficient Peroxidase-Like Activity for Colorimetric Detection of Dopamine |
| title_full | Pt Nanoparticles Anchored on NH<sub>2</sub>-MIL-101 with Efficient Peroxidase-Like Activity for Colorimetric Detection of Dopamine |
| title_fullStr | Pt Nanoparticles Anchored on NH<sub>2</sub>-MIL-101 with Efficient Peroxidase-Like Activity for Colorimetric Detection of Dopamine |
| title_full_unstemmed | Pt Nanoparticles Anchored on NH<sub>2</sub>-MIL-101 with Efficient Peroxidase-Like Activity for Colorimetric Detection of Dopamine |
| title_short | Pt Nanoparticles Anchored on NH<sub>2</sub>-MIL-101 with Efficient Peroxidase-Like Activity for Colorimetric Detection of Dopamine |
| title_sort | pt nanoparticles anchored on nh sub 2 sub mil 101 with efficient peroxidase like activity for colorimetric detection of dopamine |
| topic | peroxidase-like activity Pt NPs metal–organic framework colorimetric dopamine |
| url | https://www.mdpi.com/2227-9040/9/6/140 |
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