Granulocyte macrophage colony-stimulating factor-induced macrophages of individuals with autism spectrum disorder adversely affect neuronal dendrites through the secretion of pro-inflammatory cytokines

Granulocyte macrophage colony-stimulating factor-induced macrophages of individuals with autism spectrum disorder adversely affect neuronal dendrites through the secretion of pro-inflammatory cytokines

Abstract Background A growing body of evidence suggests that immune dysfunction and inflammation in the peripheral tissues as well as the central nervous system are associated with the neurodevelopmental deficits observed in autism spectrum disorder (ASD). Elevated expression of pro-inflammatory cyt...

Full description

Bibliographic Details
Main Authors: Ryohei Takada, Michihiro Toritsuka, Takahira Yamauchi, Rio Ishida, Yoshinori Kayashima, Yuki Nishi, Mitsuru Ishikawa, Kazuhiko Yamamuro, Minobu Ikehara, Takashi Komori, Yuki Noriyama, Kohei Kamikawa, Yasuhiko Saito, Hideyuki Okano, Manabu Makinodan
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Molecular Autism
Subjects:
Autism spectrum disorder
Human iPS cell
Macrophage
Interleukin-1α
Tumor necrosis factor-α
Dendrite
Online Access:https://doi.org/10.1186/s13229-024-00589-2

Internet

https://doi.org/10.1186/s13229-024-00589-2

Similar Items