Global epistasis in plasmid-mediated antimicrobial resistance
Abstract Antimicrobial resistance (AMR) in bacteria is a major public health threat and conjugative plasmids play a key role in the dissemination of AMR genes among bacterial pathogens. Interestingly, the association between AMR plasmids and pathogens is not random and certain associations spread su...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2024-02-01
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| Series: | Molecular Systems Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s44320-024-00012-1 |
| _version_ | 1797219488134856704 |
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| author | Javier DelaFuente Juan Diaz-Colunga Alvaro Sanchez Alvaro San Millan |
| author_facet | Javier DelaFuente Juan Diaz-Colunga Alvaro Sanchez Alvaro San Millan |
| author_sort | Javier DelaFuente |
| collection | DOAJ |
| description | Abstract Antimicrobial resistance (AMR) in bacteria is a major public health threat and conjugative plasmids play a key role in the dissemination of AMR genes among bacterial pathogens. Interestingly, the association between AMR plasmids and pathogens is not random and certain associations spread successfully at a global scale. The burst of genome sequencing has increased the resolution of epidemiological programs, broadening our understanding of plasmid distribution in bacterial populations. Despite the immense value of these studies, our ability to predict future plasmid-bacteria associations remains limited. Numerous empirical studies have recently reported systematic patterns in genetic interactions that enable predictability, in a phenomenon known as global epistasis. In this perspective, we argue that global epistasis patterns hold the potential to predict interactions between plasmids and bacterial genomes, thereby facilitating the prediction of future successful associations. To assess the validity of this idea, we use previously published data to identify global epistasis patterns in clinically relevant plasmid-bacteria associations. Furthermore, using simple mechanistic models of antibiotic resistance, we illustrate how global epistasis patterns may allow us to generate new hypotheses on the mechanisms associated with successful plasmid-bacteria associations. Collectively, we aim at illustrating the relevance of exploring global epistasis in the context of plasmid biology. |
| first_indexed | 2024-04-24T12:34:26Z |
| format | Article |
| id | doaj.art-d4379e71c8324a4c9a554cef7e92ea40 |
| institution | Directory Open Access Journal |
| issn | 1744-4292 |
| language | English |
| last_indexed | 2024-04-24T12:34:26Z |
| publishDate | 2024-02-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj.art-d4379e71c8324a4c9a554cef7e92ea402024-04-07T11:35:03ZengSpringer NatureMolecular Systems Biology1744-42922024-02-0120431132010.1038/s44320-024-00012-1Global epistasis in plasmid-mediated antimicrobial resistanceJavier DelaFuente0Juan Diaz-Colunga1Alvaro Sanchez2Alvaro San Millan3Centro Nacional de Biotecnología (CNB-CSIC)Centro Nacional de Biotecnología (CNB-CSIC)Centro Nacional de Biotecnología (CNB-CSIC)Centro Nacional de Biotecnología (CNB-CSIC)Abstract Antimicrobial resistance (AMR) in bacteria is a major public health threat and conjugative plasmids play a key role in the dissemination of AMR genes among bacterial pathogens. Interestingly, the association between AMR plasmids and pathogens is not random and certain associations spread successfully at a global scale. The burst of genome sequencing has increased the resolution of epidemiological programs, broadening our understanding of plasmid distribution in bacterial populations. Despite the immense value of these studies, our ability to predict future plasmid-bacteria associations remains limited. Numerous empirical studies have recently reported systematic patterns in genetic interactions that enable predictability, in a phenomenon known as global epistasis. In this perspective, we argue that global epistasis patterns hold the potential to predict interactions between plasmids and bacterial genomes, thereby facilitating the prediction of future successful associations. To assess the validity of this idea, we use previously published data to identify global epistasis patterns in clinically relevant plasmid-bacteria associations. Furthermore, using simple mechanistic models of antibiotic resistance, we illustrate how global epistasis patterns may allow us to generate new hypotheses on the mechanisms associated with successful plasmid-bacteria associations. Collectively, we aim at illustrating the relevance of exploring global epistasis in the context of plasmid biology.https://doi.org/10.1038/s44320-024-00012-1Global EpistasisAntimicrobial ResistancePlasmidsMicrobiologyEvolution |
| spellingShingle | Javier DelaFuente Juan Diaz-Colunga Alvaro Sanchez Alvaro San Millan Global epistasis in plasmid-mediated antimicrobial resistance Molecular Systems Biology Global Epistasis Antimicrobial Resistance Plasmids Microbiology Evolution |
| title | Global epistasis in plasmid-mediated antimicrobial resistance |
| title_full | Global epistasis in plasmid-mediated antimicrobial resistance |
| title_fullStr | Global epistasis in plasmid-mediated antimicrobial resistance |
| title_full_unstemmed | Global epistasis in plasmid-mediated antimicrobial resistance |
| title_short | Global epistasis in plasmid-mediated antimicrobial resistance |
| title_sort | global epistasis in plasmid mediated antimicrobial resistance |
| topic | Global Epistasis Antimicrobial Resistance Plasmids Microbiology Evolution |
| url | https://doi.org/10.1038/s44320-024-00012-1 |
| work_keys_str_mv | AT javierdelafuente globalepistasisinplasmidmediatedantimicrobialresistance AT juandiazcolunga globalepistasisinplasmidmediatedantimicrobialresistance AT alvarosanchez globalepistasisinplasmidmediatedantimicrobialresistance AT alvarosanmillan globalepistasisinplasmidmediatedantimicrobialresistance |