Association of the neutrophil-to-lymphocyte ratio and prostate cancer detection rates in patients via contemporary multi-core prostate biopsy
The aim of this study was to determine whether the neutrophil-to-lymphocyte ratio (NLR), a measure of the systemic inflammatory response is associated with the overall prostate cancer detection rate in men who underwent contemporary multi (≥12)-core transrectal ultrasound (TRUS) biopsy. We reviewed...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=6;spage=937;epage=941;aulast=Oh |
| _version_ | 1811256728351670272 |
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| author | Jong Jin Oh Ohsung Kwon Jung Keun Lee Seok-Soo Byun Sang Eun Lee Sangchul Lee Sung Kyu Hong |
| author_facet | Jong Jin Oh Ohsung Kwon Jung Keun Lee Seok-Soo Byun Sang Eun Lee Sangchul Lee Sung Kyu Hong |
| author_sort | Jong Jin Oh |
| collection | DOAJ |
| description | The aim of this study was to determine whether the neutrophil-to-lymphocyte ratio (NLR), a measure of the systemic inflammatory response is associated with the overall prostate cancer detection rate in men who underwent contemporary multi (≥12)-core transrectal ultrasound (TRUS) biopsy. We reviewed the records of 3913 patients with initial prostate-specific antigen (PSA) levels ranging from 4 to 10 ng ml−1 who underwent TRUS-guided prostate biopsy between April 2006 and May 2014. NLR was calculated by prebiopsy neutrophil and lymphocyte counts. We excluded patients who had evidence of acute prostatitis, a history of prostate surgery, and any systemic inflammatory disease. A multivariate logistic regression model was used to analyze prostate cancer detection. After adjusting for confounding factors, predictive values were determined according to the receiver operating characteristic-derived area under the curve, both including and excluding the NLR variable. In univariate analyses, NLR was a significant predictor of prostate cancer detection (P < 0.001). In multivariate analyses, a higher NLR was significantly associated with prostate cancer detection after adjusting for other factors (OR = 1.372, P= 0.038). The addition of NLR increased the accuracy from 0.712 to 0.725 (P = 0.005) in the multivariate model for prostate cancer detection. NLR may be a potentially useful clinical marker in the detection of prostate cancer among men with a PSA level in the 4-10 ng ml−1 range. These findings are derived from a retrospective analysis and should be validated in larger populations through prospective studies. |
| first_indexed | 2024-04-12T17:45:38Z |
| format | Article |
| id | doaj.art-d4391bef2bf84b0199c00b069dbc3fcb |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-04-12T17:45:38Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-d4391bef2bf84b0199c00b069dbc3fcb2022-12-22T03:22:40ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622016-01-0118693794110.4103/1008-682X.164198Association of the neutrophil-to-lymphocyte ratio and prostate cancer detection rates in patients via contemporary multi-core prostate biopsyJong Jin OhOhsung KwonJung Keun LeeSeok-Soo ByunSang Eun LeeSangchul LeeSung Kyu HongThe aim of this study was to determine whether the neutrophil-to-lymphocyte ratio (NLR), a measure of the systemic inflammatory response is associated with the overall prostate cancer detection rate in men who underwent contemporary multi (≥12)-core transrectal ultrasound (TRUS) biopsy. We reviewed the records of 3913 patients with initial prostate-specific antigen (PSA) levels ranging from 4 to 10 ng ml−1 who underwent TRUS-guided prostate biopsy between April 2006 and May 2014. NLR was calculated by prebiopsy neutrophil and lymphocyte counts. We excluded patients who had evidence of acute prostatitis, a history of prostate surgery, and any systemic inflammatory disease. A multivariate logistic regression model was used to analyze prostate cancer detection. After adjusting for confounding factors, predictive values were determined according to the receiver operating characteristic-derived area under the curve, both including and excluding the NLR variable. In univariate analyses, NLR was a significant predictor of prostate cancer detection (P < 0.001). In multivariate analyses, a higher NLR was significantly associated with prostate cancer detection after adjusting for other factors (OR = 1.372, P= 0.038). The addition of NLR increased the accuracy from 0.712 to 0.725 (P = 0.005) in the multivariate model for prostate cancer detection. NLR may be a potentially useful clinical marker in the detection of prostate cancer among men with a PSA level in the 4-10 ng ml−1 range. These findings are derived from a retrospective analysis and should be validated in larger populations through prospective studies.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=6;spage=937;epage=941;aulast=Ohinflammation; lymphocyte; neutrophil; prostate biopsy; prostate cancer |
| spellingShingle | Jong Jin Oh Ohsung Kwon Jung Keun Lee Seok-Soo Byun Sang Eun Lee Sangchul Lee Sung Kyu Hong Association of the neutrophil-to-lymphocyte ratio and prostate cancer detection rates in patients via contemporary multi-core prostate biopsy Asian Journal of Andrology inflammation; lymphocyte; neutrophil; prostate biopsy; prostate cancer |
| title | Association of the neutrophil-to-lymphocyte ratio and prostate cancer detection rates in patients via contemporary multi-core prostate biopsy |
| title_full | Association of the neutrophil-to-lymphocyte ratio and prostate cancer detection rates in patients via contemporary multi-core prostate biopsy |
| title_fullStr | Association of the neutrophil-to-lymphocyte ratio and prostate cancer detection rates in patients via contemporary multi-core prostate biopsy |
| title_full_unstemmed | Association of the neutrophil-to-lymphocyte ratio and prostate cancer detection rates in patients via contemporary multi-core prostate biopsy |
| title_short | Association of the neutrophil-to-lymphocyte ratio and prostate cancer detection rates in patients via contemporary multi-core prostate biopsy |
| title_sort | association of the neutrophil to lymphocyte ratio and prostate cancer detection rates in patients via contemporary multi core prostate biopsy |
| topic | inflammation; lymphocyte; neutrophil; prostate biopsy; prostate cancer |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=6;spage=937;epage=941;aulast=Oh |
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