VENDOTOXIN IMMUNITY AND LEVEL OF С-REACTIVE PROTEIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON HEMODIALYSIS AND PERITONEAL DIALYSIS
Purpose: studying of endotoxin antibodies level of classes G, M, A and level of C-reactive protein at patients on a programhemodialysis and a constant peritoneal dialysis.Materials and methods:16 patients with a chronic kidneys disease 5 stage on a peritoneal dialysis and 62 patients on a program he...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2015-12-01
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| Series: | Медицинский вестник Юга России |
| Subjects: | |
| Online Access: | https://www.medicalherald.ru/jour/article/view/253 |
| _version_ | 1811179499461541888 |
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| author | V. A. Biloglazov A. V. Klimchuk |
| author_facet | V. A. Biloglazov A. V. Klimchuk |
| author_sort | V. A. Biloglazov |
| collection | DOAJ |
| description | Purpose: studying of endotoxin antibodies level of classes G, M, A and level of C-reactive protein at patients on a programhemodialysis and a constant peritoneal dialysis.Materials and methods:16 patients with a chronic kidneys disease 5 stage on a peritoneal dialysis and 62 patients on a program hemodialysis are surveyed. Level endotoxin antibody classes G, M, A, and C-reactive protein was determined by ELISA.Results: it is established that patients on a peritonial dialysis have level anti-ET-IgG in 4.9 times in comparison with group of conditionally healthy patients, and levels anti-ET-IgA and anti-ET-IgM didn’t differ from norm indicators. Also increase of level of C-reactive protein in 8.8 times, in comparison with indicators of healthy donors. At patients on a program hemodialysis increase in 5.6 times anti-ET-IgG, and in 8 times of C-reactive protein in comparison with group of healthy patients. And levels anti-ET-IgA and anti-ET-IgM also didn’t differ from norm indicators. Levels of endotoxin antibodies and C-reactive protein at patients on a hemodialysis and on a peritonial dialysis among didn’t differ.Conclusion: in both groups of patients found an increased antibody response to ET (on a high level of anti-ET-IgG) against the background of a high level of systemic inflammation (at the level of C-reactive protein). There is chronic endotoxin aggression in hemodialysis patients. |
| first_indexed | 2024-04-11T06:35:22Z |
| format | Article |
| id | doaj.art-d43a7773e0124e228300454dccc009d1 |
| institution | Directory Open Access Journal |
| issn | 2219-8075 2618-7876 |
| language | English |
| last_indexed | 2024-04-11T06:35:22Z |
| publishDate | 2015-12-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Медицинский вестник Юга России |
| spelling | doaj.art-d43a7773e0124e228300454dccc009d12022-12-22T04:39:50ZengState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationМедицинский вестник Юга России2219-80752618-78762015-12-0104182110.21886/2219-8075-2015-4-18-21252VENDOTOXIN IMMUNITY AND LEVEL OF С-REACTIVE PROTEIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON HEMODIALYSIS AND PERITONEAL DIALYSISV. A. Biloglazov0A. V. Klimchuk1FSAEE AE «Crimean Federal University named after V.I. Vernadsky», Medical Academy named after S.I. GeorgievskyFSAEE AE «Crimean Federal University named after V.I. Vernadsky», Medical Academy named after S.I. GeorgievskyPurpose: studying of endotoxin antibodies level of classes G, M, A and level of C-reactive protein at patients on a programhemodialysis and a constant peritoneal dialysis.Materials and methods:16 patients with a chronic kidneys disease 5 stage on a peritoneal dialysis and 62 patients on a program hemodialysis are surveyed. Level endotoxin antibody classes G, M, A, and C-reactive protein was determined by ELISA.Results: it is established that patients on a peritonial dialysis have level anti-ET-IgG in 4.9 times in comparison with group of conditionally healthy patients, and levels anti-ET-IgA and anti-ET-IgM didn’t differ from norm indicators. Also increase of level of C-reactive protein in 8.8 times, in comparison with indicators of healthy donors. At patients on a program hemodialysis increase in 5.6 times anti-ET-IgG, and in 8 times of C-reactive protein in comparison with group of healthy patients. And levels anti-ET-IgA and anti-ET-IgM also didn’t differ from norm indicators. Levels of endotoxin antibodies and C-reactive protein at patients on a hemodialysis and on a peritonial dialysis among didn’t differ.Conclusion: in both groups of patients found an increased antibody response to ET (on a high level of anti-ET-IgG) against the background of a high level of systemic inflammation (at the level of C-reactive protein). There is chronic endotoxin aggression in hemodialysis patients.https://www.medicalherald.ru/jour/article/view/253chronic kidney diseasedialysischronic inflammationendotoxinendotoxin immunity |
| spellingShingle | V. A. Biloglazov A. V. Klimchuk VENDOTOXIN IMMUNITY AND LEVEL OF С-REACTIVE PROTEIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON HEMODIALYSIS AND PERITONEAL DIALYSIS Медицинский вестник Юга России chronic kidney disease dialysis chronic inflammation endotoxin endotoxin immunity |
| title | VENDOTOXIN IMMUNITY AND LEVEL OF С-REACTIVE PROTEIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON HEMODIALYSIS AND PERITONEAL DIALYSIS |
| title_full | VENDOTOXIN IMMUNITY AND LEVEL OF С-REACTIVE PROTEIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON HEMODIALYSIS AND PERITONEAL DIALYSIS |
| title_fullStr | VENDOTOXIN IMMUNITY AND LEVEL OF С-REACTIVE PROTEIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON HEMODIALYSIS AND PERITONEAL DIALYSIS |
| title_full_unstemmed | VENDOTOXIN IMMUNITY AND LEVEL OF С-REACTIVE PROTEIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON HEMODIALYSIS AND PERITONEAL DIALYSIS |
| title_short | VENDOTOXIN IMMUNITY AND LEVEL OF С-REACTIVE PROTEIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE ON HEMODIALYSIS AND PERITONEAL DIALYSIS |
| title_sort | vendotoxin immunity and level of с reactive protein in patients with chronic kidney disease on hemodialysis and peritoneal dialysis |
| topic | chronic kidney disease dialysis chronic inflammation endotoxin endotoxin immunity |
| url | https://www.medicalherald.ru/jour/article/view/253 |
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