Approaching Sex Differences in Cardiovascular Non-Coding RNA Research
Cardiovascular disease (CVD) is the biggest cause of sickness and mortality worldwide in both males and females. Clinical statistics demonstrate clear sex differences in risk, prevalence, mortality rates, and response to treatment for different entities of CVD. The reason for this remains poorly und...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/14/4890 |
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| author | Amela Jusic Antonio Salgado-Somoza Ana B. Paes Francesca Maria Stefanizzi Núria Martínez-Alarcón Florence Pinet Fabio Martelli Yvan Devaux Emma Louise Robinson Susana Novella |
| author_facet | Amela Jusic Antonio Salgado-Somoza Ana B. Paes Francesca Maria Stefanizzi Núria Martínez-Alarcón Florence Pinet Fabio Martelli Yvan Devaux Emma Louise Robinson Susana Novella |
| author_sort | Amela Jusic |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is the biggest cause of sickness and mortality worldwide in both males and females. Clinical statistics demonstrate clear sex differences in risk, prevalence, mortality rates, and response to treatment for different entities of CVD. The reason for this remains poorly understood. Non-coding RNAs (ncRNAs) are emerging as key mediators and biomarkers of CVD. Similarly, current knowledge on differential regulation, expression, and pathology-associated function of ncRNAs between sexes is minimal. Here, we provide a state-of-the-art overview of what is known on sex differences in ncRNA research in CVD as well as discussing the contributing biological factors to this sex dimorphism including genetic and epigenetic factors and sex hormone regulation of transcription. We then focus on the experimental models of CVD and their use in translational ncRNA research in the cardiovascular field. In particular, we want to highlight the importance of considering sex of the cellular and pre-clinical models in clinical studies in ncRNA research and to carefully consider the appropriate experimental models most applicable to human patient populations. Moreover, we aim to identify sex-specific targets for treatment and diagnosis for the biggest socioeconomic health problem globally. |
| first_indexed | 2024-03-10T18:32:59Z |
| format | Article |
| id | doaj.art-d43d599e37d64be5a4b1e9aeed588312 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:32:59Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d43d599e37d64be5a4b1e9aeed5883122023-11-20T06:28:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012114489010.3390/ijms21144890Approaching Sex Differences in Cardiovascular Non-Coding RNA ResearchAmela Jusic0Antonio Salgado-Somoza1Ana B. Paes2Francesca Maria Stefanizzi3Núria Martínez-Alarcón4Florence Pinet5Fabio Martelli6Yvan Devaux7Emma Louise Robinson8Susana Novella9Department of Biology, Faculty of Natural Sciences and Mathematics, University of Tuzla, 75000 Tuzla, Bosnia and HerzegovinaCardiovascular Research Unit, Department of Population Health, Luxembourg Institute of Health, L-1445 Strassen, LuxembourgINCLIVA Biomedical Research Institute, Menéndez Pelayo 4 Accesorio, 46010 Valencia, SpainCardiovascular Research Unit, Department of Population Health, Luxembourg Institute of Health, L-1445 Strassen, LuxembourgINCLIVA Biomedical Research Institute, Menéndez Pelayo 4 Accesorio, 46010 Valencia, SpainINSERM, CHU Lille, Institut Pasteur de Lille, University of Lille, U1167 F-59000 Lille, FranceMolecular Cardiology Laboratory, Policlinico San Donato IRCCS, San Donato Milanese, 20097 Milan, ItalyCardiovascular Research Unit, Department of Population Health, Luxembourg Institute of Health, L-1445 Strassen, LuxembourgDepartment of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 ER Maastricht, The NetherlandsDepartment of Physiology, Faculty of Medicine and Dentistry, University of Valencia, and INCLIVA Biomedical Research Institute, Menéndez Pelayo 4 Accesorio, 46010 Valencia, SpainCardiovascular disease (CVD) is the biggest cause of sickness and mortality worldwide in both males and females. Clinical statistics demonstrate clear sex differences in risk, prevalence, mortality rates, and response to treatment for different entities of CVD. The reason for this remains poorly understood. Non-coding RNAs (ncRNAs) are emerging as key mediators and biomarkers of CVD. Similarly, current knowledge on differential regulation, expression, and pathology-associated function of ncRNAs between sexes is minimal. Here, we provide a state-of-the-art overview of what is known on sex differences in ncRNA research in CVD as well as discussing the contributing biological factors to this sex dimorphism including genetic and epigenetic factors and sex hormone regulation of transcription. We then focus on the experimental models of CVD and their use in translational ncRNA research in the cardiovascular field. In particular, we want to highlight the importance of considering sex of the cellular and pre-clinical models in clinical studies in ncRNA research and to carefully consider the appropriate experimental models most applicable to human patient populations. Moreover, we aim to identify sex-specific targets for treatment and diagnosis for the biggest socioeconomic health problem globally.https://www.mdpi.com/1422-0067/21/14/4890ncRNAmiRNAlncRNAcardiovascular diseasesexperimental modelsvascular cells |
| spellingShingle | Amela Jusic Antonio Salgado-Somoza Ana B. Paes Francesca Maria Stefanizzi Núria Martínez-Alarcón Florence Pinet Fabio Martelli Yvan Devaux Emma Louise Robinson Susana Novella Approaching Sex Differences in Cardiovascular Non-Coding RNA Research International Journal of Molecular Sciences ncRNA miRNA lncRNA cardiovascular diseases experimental models vascular cells |
| title | Approaching Sex Differences in Cardiovascular Non-Coding RNA Research |
| title_full | Approaching Sex Differences in Cardiovascular Non-Coding RNA Research |
| title_fullStr | Approaching Sex Differences in Cardiovascular Non-Coding RNA Research |
| title_full_unstemmed | Approaching Sex Differences in Cardiovascular Non-Coding RNA Research |
| title_short | Approaching Sex Differences in Cardiovascular Non-Coding RNA Research |
| title_sort | approaching sex differences in cardiovascular non coding rna research |
| topic | ncRNA miRNA lncRNA cardiovascular diseases experimental models vascular cells |
| url | https://www.mdpi.com/1422-0067/21/14/4890 |
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