The Neurobiology of Infant Attachment-Trauma and Disruption of Parent–Infant Interactions
Current clinical literature and supporting animal literature have shown that repeated and profound early-life adversity, especially when experienced within the caregiver–infant dyad, disrupts the trajectory of brain development to induce later-life expression of maladaptive behavior and pathology. W...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.882464/full |
| _version_ | 1818190499739074560 |
|---|---|
| author | Nimra Naeem Nimra Naeem Nimra Naeem Roseanna M. Zanca Roseanna M. Zanca Sylvie Weinstein Sylvie Weinstein Alejandra Urquieta Alejandra Urquieta Anna Sosa Anna Sosa Boyi Yu Boyi Yu Regina M. Sullivan Regina M. Sullivan Regina M. Sullivan |
| author_facet | Nimra Naeem Nimra Naeem Nimra Naeem Roseanna M. Zanca Roseanna M. Zanca Sylvie Weinstein Sylvie Weinstein Alejandra Urquieta Alejandra Urquieta Anna Sosa Anna Sosa Boyi Yu Boyi Yu Regina M. Sullivan Regina M. Sullivan Regina M. Sullivan |
| author_sort | Nimra Naeem |
| collection | DOAJ |
| description | Current clinical literature and supporting animal literature have shown that repeated and profound early-life adversity, especially when experienced within the caregiver–infant dyad, disrupts the trajectory of brain development to induce later-life expression of maladaptive behavior and pathology. What is less well understood is the immediate impact of repeated adversity during early life with the caregiver, especially since attachment to the caregiver occurs regardless of the quality of care the infant received including experiences of trauma. The focus of the present manuscript is to review the current literature on infant trauma within attachment, with an emphasis on animal research to define mechanisms and translate developmental child research. Across species, the effects of repeated trauma with the attachment figure, are subtle in early life, but the presence of acute stress can uncover some pathology, as was highlighted by Bowlby and Ainsworth in the 1950s. Through rodent neurobehavioral literature we discuss the important role of repeated elevations in stress hormone corticosterone (CORT) in infancy, especially if paired with the mother (not when pups are alone) as targeting the amygdala and causal in infant pathology. We also show that following induced alterations, at baseline infants appear stable, although acute stress hormone elevation uncovers pathology in brain circuits important in emotion, social behavior, and fear. We suggest that a comprehensive understanding of the role of stress hormones during infant typical development and elevated CORT disruption of this typical development will provide insight into age-specific identification of trauma effects, as well as a better understanding of early markers of later-life pathology. |
| first_indexed | 2024-12-11T23:59:41Z |
| format | Article |
| id | doaj.art-d43d6b002fa6483586f3f4248a18382e |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-11T23:59:41Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-d43d6b002fa6483586f3f4248a18382e2022-12-22T00:45:15ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532022-07-011610.3389/fnbeh.2022.882464882464The Neurobiology of Infant Attachment-Trauma and Disruption of Parent–Infant InteractionsNimra Naeem0Nimra Naeem1Nimra Naeem2Roseanna M. Zanca3Roseanna M. Zanca4Sylvie Weinstein5Sylvie Weinstein6Alejandra Urquieta7Alejandra Urquieta8Anna Sosa9Anna Sosa10Boyi Yu11Boyi Yu12Regina M. Sullivan13Regina M. Sullivan14Regina M. Sullivan15Department of Psychology, Center for Neuroscience, New York University, New York, NY, United StatesEmotional Brain Institute, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, United StatesChild and Adolescent Psychiatry, New York University Langone School of Medicine, New York, NY, United StatesEmotional Brain Institute, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, United StatesChild and Adolescent Psychiatry, New York University Langone School of Medicine, New York, NY, United StatesDepartment of Psychology, Center for Neuroscience, New York University, New York, NY, United StatesChild and Adolescent Psychiatry, New York University Langone School of Medicine, New York, NY, United StatesDepartment of Psychology, Center for Neuroscience, New York University, New York, NY, United StatesChild and Adolescent Psychiatry, New York University Langone School of Medicine, New York, NY, United StatesDepartment of Psychology, Center for Neuroscience, New York University, New York, NY, United StatesChild and Adolescent Psychiatry, New York University Langone School of Medicine, New York, NY, United StatesDepartment of Psychology, Center for Neuroscience, New York University, New York, NY, United StatesChild and Adolescent Psychiatry, New York University Langone School of Medicine, New York, NY, United StatesDepartment of Psychology, Center for Neuroscience, New York University, New York, NY, United StatesEmotional Brain Institute, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, United StatesChild and Adolescent Psychiatry, New York University Langone School of Medicine, New York, NY, United StatesCurrent clinical literature and supporting animal literature have shown that repeated and profound early-life adversity, especially when experienced within the caregiver–infant dyad, disrupts the trajectory of brain development to induce later-life expression of maladaptive behavior and pathology. What is less well understood is the immediate impact of repeated adversity during early life with the caregiver, especially since attachment to the caregiver occurs regardless of the quality of care the infant received including experiences of trauma. The focus of the present manuscript is to review the current literature on infant trauma within attachment, with an emphasis on animal research to define mechanisms and translate developmental child research. Across species, the effects of repeated trauma with the attachment figure, are subtle in early life, but the presence of acute stress can uncover some pathology, as was highlighted by Bowlby and Ainsworth in the 1950s. Through rodent neurobehavioral literature we discuss the important role of repeated elevations in stress hormone corticosterone (CORT) in infancy, especially if paired with the mother (not when pups are alone) as targeting the amygdala and causal in infant pathology. We also show that following induced alterations, at baseline infants appear stable, although acute stress hormone elevation uncovers pathology in brain circuits important in emotion, social behavior, and fear. We suggest that a comprehensive understanding of the role of stress hormones during infant typical development and elevated CORT disruption of this typical development will provide insight into age-specific identification of trauma effects, as well as a better understanding of early markers of later-life pathology.https://www.frontiersin.org/articles/10.3389/fnbeh.2022.882464/fulladversitytrauma bondingattachmentsocial bufferingchild abusemother-infant dyad |
| spellingShingle | Nimra Naeem Nimra Naeem Nimra Naeem Roseanna M. Zanca Roseanna M. Zanca Sylvie Weinstein Sylvie Weinstein Alejandra Urquieta Alejandra Urquieta Anna Sosa Anna Sosa Boyi Yu Boyi Yu Regina M. Sullivan Regina M. Sullivan Regina M. Sullivan The Neurobiology of Infant Attachment-Trauma and Disruption of Parent–Infant Interactions Frontiers in Behavioral Neuroscience adversity trauma bonding attachment social buffering child abuse mother-infant dyad |
| title | The Neurobiology of Infant Attachment-Trauma and Disruption of Parent–Infant Interactions |
| title_full | The Neurobiology of Infant Attachment-Trauma and Disruption of Parent–Infant Interactions |
| title_fullStr | The Neurobiology of Infant Attachment-Trauma and Disruption of Parent–Infant Interactions |
| title_full_unstemmed | The Neurobiology of Infant Attachment-Trauma and Disruption of Parent–Infant Interactions |
| title_short | The Neurobiology of Infant Attachment-Trauma and Disruption of Parent–Infant Interactions |
| title_sort | neurobiology of infant attachment trauma and disruption of parent infant interactions |
| topic | adversity trauma bonding attachment social buffering child abuse mother-infant dyad |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.882464/full |
| work_keys_str_mv | AT nimranaeem theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT nimranaeem theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT nimranaeem theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT roseannamzanca theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT roseannamzanca theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT sylvieweinstein theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT sylvieweinstein theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT alejandraurquieta theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT alejandraurquieta theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT annasosa theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT annasosa theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT boyiyu theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT boyiyu theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT reginamsullivan theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT reginamsullivan theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT reginamsullivan theneurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT nimranaeem neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT nimranaeem neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT nimranaeem neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT roseannamzanca neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT roseannamzanca neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT sylvieweinstein neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT sylvieweinstein neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT alejandraurquieta neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT alejandraurquieta neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT annasosa neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT annasosa neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT boyiyu neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT boyiyu neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT reginamsullivan neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT reginamsullivan neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions AT reginamsullivan neurobiologyofinfantattachmenttraumaanddisruptionofparentinfantinteractions |