An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes
Background: Over the last decades, various approaches have been explored to restore sufficient β-cell mass in diabetic patients. Stem cells are certainly an attractive source of new β-cells, but an alternative option is to induce the endogenous regeneration of these cells. Scope of Review: Since the...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
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| Series: | Molecular Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212877823000881 |
| _version_ | 1797779221777481728 |
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| author | Laura Soldovieri Gianfranco Di Giuseppe Gea Ciccarelli Giuseppe Quero Francesca Cinti Michela Brunetti Enrico C. Nista Antonio Gasbarrini Sergio Alfieri Alfredo Pontecorvi Andrea Giaccari Teresa Mezza |
| author_facet | Laura Soldovieri Gianfranco Di Giuseppe Gea Ciccarelli Giuseppe Quero Francesca Cinti Michela Brunetti Enrico C. Nista Antonio Gasbarrini Sergio Alfieri Alfredo Pontecorvi Andrea Giaccari Teresa Mezza |
| author_sort | Laura Soldovieri |
| collection | DOAJ |
| description | Background: Over the last decades, various approaches have been explored to restore sufficient β-cell mass in diabetic patients. Stem cells are certainly an attractive source of new β-cells, but an alternative option is to induce the endogenous regeneration of these cells. Scope of Review: Since the exocrine and endocrine pancreatic glands have a common origin and a continuous crosstalk unites the two, we believe that analyzing the mechanisms that induce pancreatic regeneration in different conditions could further advance our knowledge in the field. In this review, we summarize the latest evidence on physiological and pathological conditions associated with the regulation of pancreas regeneration and proliferation, as well as the complex and coordinated signaling cascade mediating cell growth. Major conclusions: Unraveling the mechanisms involved in intracellular signaling and regulation of pancreatic cell proliferation and regeneration may inspire future investigations to discover potential strategies to cure diabetes. |
| first_indexed | 2024-03-12T23:27:35Z |
| format | Article |
| id | doaj.art-d43e32cf29044d3c8ac89abf182b502f |
| institution | Directory Open Access Journal |
| issn | 2212-8778 |
| language | English |
| last_indexed | 2024-03-12T23:27:35Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Metabolism |
| spelling | doaj.art-d43e32cf29044d3c8ac89abf182b502f2023-07-16T04:18:29ZengElsevierMolecular Metabolism2212-87782023-08-0174101754An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetesLaura Soldovieri0Gianfranco Di Giuseppe1Gea Ciccarelli2Giuseppe Quero3Francesca Cinti4Michela Brunetti5Enrico C. Nista6Antonio Gasbarrini7Sergio Alfieri8Alfredo Pontecorvi9Andrea Giaccari10Teresa Mezza11Endocrinologia e Diabetologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyEndocrinologia e Diabetologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyEndocrinologia e Diabetologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy; Chirurgia Digestiva, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, ItalyEndocrinologia e Diabetologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyEndocrinologia e Diabetologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyPancreas Unit, CEMAD Centro Malattie dell'Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, ItalyDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy; Pancreas Unit, CEMAD Centro Malattie dell'Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, ItalyDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy; Chirurgia Digestiva, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, ItalyEndocrinologia e Diabetologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, ItalyEndocrinologia e Diabetologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy; Corresponding author. Endocrinologia e Diabetologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy; Pancreas Unit, CEMAD Centro Malattie dell'Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy; Corresponding author. Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.Background: Over the last decades, various approaches have been explored to restore sufficient β-cell mass in diabetic patients. Stem cells are certainly an attractive source of new β-cells, but an alternative option is to induce the endogenous regeneration of these cells. Scope of Review: Since the exocrine and endocrine pancreatic glands have a common origin and a continuous crosstalk unites the two, we believe that analyzing the mechanisms that induce pancreatic regeneration in different conditions could further advance our knowledge in the field. In this review, we summarize the latest evidence on physiological and pathological conditions associated with the regulation of pancreas regeneration and proliferation, as well as the complex and coordinated signaling cascade mediating cell growth. Major conclusions: Unraveling the mechanisms involved in intracellular signaling and regulation of pancreatic cell proliferation and regeneration may inspire future investigations to discover potential strategies to cure diabetes.http://www.sciencedirect.com/science/article/pii/S2212877823000881Pancreas regenerationProliferationExocrine pancreasIslet plasticity |
| spellingShingle | Laura Soldovieri Gianfranco Di Giuseppe Gea Ciccarelli Giuseppe Quero Francesca Cinti Michela Brunetti Enrico C. Nista Antonio Gasbarrini Sergio Alfieri Alfredo Pontecorvi Andrea Giaccari Teresa Mezza An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes Molecular Metabolism Pancreas regeneration Proliferation Exocrine pancreas Islet plasticity |
| title | An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes |
| title_full | An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes |
| title_fullStr | An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes |
| title_full_unstemmed | An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes |
| title_short | An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes |
| title_sort | update on pancreatic regeneration mechanisms searching for paths to a cure for type 2 diabetes |
| topic | Pancreas regeneration Proliferation Exocrine pancreas Islet plasticity |
| url | http://www.sciencedirect.com/science/article/pii/S2212877823000881 |
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