An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base
An efficient base-catalyzed synthesis of arylated pyridines has been disclosed. This reaction involving conjugated acetylenes and substituted benzylamines proceeded smoothly, giving rise to tri-aryl substituted pyridines which are biologically relevant compounds in good to excellent yields in N,N-di...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-07-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/22/8/1277 |
| _version_ | 1818391777370963968 |
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| author | Mengping Guo Bo Chen Qiming Zhu Hua Jin Qiuling Peng Yanping Kang |
| author_facet | Mengping Guo Bo Chen Qiming Zhu Hua Jin Qiuling Peng Yanping Kang |
| author_sort | Mengping Guo |
| collection | DOAJ |
| description | An efficient base-catalyzed synthesis of arylated pyridines has been disclosed. This reaction involving conjugated acetylenes and substituted benzylamines proceeded smoothly, giving rise to tri-aryl substituted pyridines which are biologically relevant compounds in good to excellent yields in N,N-dimethylformamide (DMF) under air at 140 °C with K2CO3 as catalyst. |
| first_indexed | 2024-12-14T05:18:55Z |
| format | Article |
| id | doaj.art-d43e35572df3466781d2b8e6f0e5ffec |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-14T05:18:55Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d43e35572df3466781d2b8e6f0e5ffec2022-12-21T23:15:44ZengMDPI AGMolecules1420-30492017-07-01228127710.3390/molecules22081277molecules22081277An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by BaseMengping Guo0Bo Chen1Qiming Zhu2Hua Jin3Qiuling Peng4Yanping Kang5College of Chemistry and Bio-Engineering, Yichun University, Yichun 336000, Jiangxi, ChinaCollege of Chemistry and Bio-Engineering, Yichun University, Yichun 336000, Jiangxi, ChinaCollege of Chemistry and Bio-Engineering, Yichun University, Yichun 336000, Jiangxi, ChinaCollege of Chemistry and Bio-Engineering, Yichun University, Yichun 336000, Jiangxi, ChinaCollege of Chemistry and Bio-Engineering, Yichun University, Yichun 336000, Jiangxi, ChinaCollege of Chemistry and Bio-Engineering, Yichun University, Yichun 336000, Jiangxi, ChinaAn efficient base-catalyzed synthesis of arylated pyridines has been disclosed. This reaction involving conjugated acetylenes and substituted benzylamines proceeded smoothly, giving rise to tri-aryl substituted pyridines which are biologically relevant compounds in good to excellent yields in N,N-dimethylformamide (DMF) under air at 140 °C with K2CO3 as catalyst.https://www.mdpi.com/1420-3049/22/8/1277arylated pyridinessynthesistransition-metal-freebasecatalysis |
| spellingShingle | Mengping Guo Bo Chen Qiming Zhu Hua Jin Qiuling Peng Yanping Kang An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base Molecules arylated pyridines synthesis transition-metal-free base catalysis |
| title | An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base |
| title_full | An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base |
| title_fullStr | An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base |
| title_full_unstemmed | An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base |
| title_short | An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base |
| title_sort | efficient synthesis of arylated pyridines from conjugated acetylenes and substituted benzylamines catalyzed by base |
| topic | arylated pyridines synthesis transition-metal-free base catalysis |
| url | https://www.mdpi.com/1420-3049/22/8/1277 |
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