HYPOLIPIDEMIC EFFECT LEUCOMISINE MODEL OF ACUTE HYPERLIPIDEMIA INDUCED BY ETHANOL
Leucomisine model of acute hyperlipidemia in rats induced by administration of ethanol reduces the levels of free fatty acids and triacylglycerols in serum and the content of triacylglycerols in the liver of experimental animals. Introduction sesquiterpenoid leucomisine increases the activity of enz...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2013-02-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/9 |
| _version_ | 1797872997184307200 |
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| author | E. A. Rodnova V. V. Ivanov S. I. Ledyukova V. S. Chuchalin A. V. Ratkin B. B. Rakhimova I. A. Khabarov S. M. Adekenov |
| author_facet | E. A. Rodnova V. V. Ivanov S. I. Ledyukova V. S. Chuchalin A. V. Ratkin B. B. Rakhimova I. A. Khabarov S. M. Adekenov |
| author_sort | E. A. Rodnova |
| collection | DOAJ |
| description | Leucomisine model of acute hyperlipidemia in rats induced by administration of ethanol reduces the levels of free fatty acids and triacylglycerols in serum and the content of triacylglycerols in the liver of experimental animals. Introduction sesquiterpenoid leucomisine increases the activity of enzymes antiperoxidant protecti- on – glutathione peroxidase and glutathione reductase and the level of total and reduced glutathione, which prevents the activation of lipid peroxidation in the liver caused by ethanol. Lipid-lowering effect induced by the hyperlipidemia leucomisine when, like nicotinic acid, may be due to an inhibitory effect on lipolysis in adipose tissue. Along with this leucomisine has an antioxidant effect due to the activation of enzymes antiperoxidant protect and increase the redox potential of glutathione in the liver of rats. |
| first_indexed | 2024-04-10T01:09:10Z |
| format | Article |
| id | doaj.art-d43e78c6ebc24bed916c36e7b817e5a2 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:09:10Z |
| publishDate | 2013-02-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-d43e78c6ebc24bed916c36e7b817e5a22023-03-13T09:58:18ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842013-02-01121434810.20538/1682-0363-2013-1-43-489HYPOLIPIDEMIC EFFECT LEUCOMISINE MODEL OF ACUTE HYPERLIPIDEMIA INDUCED BY ETHANOLE. A. Rodnova0V. V. Ivanov1S. I. Ledyukova2V. S. Chuchalin3A. V. Ratkin4B. B. Rakhimova5I. A. Khabarov6S. M. Adekenov7Сибирский государственный медицинский университет, ТомскСибирский государственный медицинский университет, ТомскСибирский государственный медицинский университет, ТомскСибирский государственный медицинский университет, ТомскСибирский государственный медицинский университет, ТомскМеждународный научно-производственный холдинг „Фитохимия“, КарагандаМеждународный научно-производственный холдинг „Фитохимия“, КарагандаМеждународный научно-производственный холдинг „Фитохимия“, КарагандаLeucomisine model of acute hyperlipidemia in rats induced by administration of ethanol reduces the levels of free fatty acids and triacylglycerols in serum and the content of triacylglycerols in the liver of experimental animals. Introduction sesquiterpenoid leucomisine increases the activity of enzymes antiperoxidant protecti- on – glutathione peroxidase and glutathione reductase and the level of total and reduced glutathione, which prevents the activation of lipid peroxidation in the liver caused by ethanol. Lipid-lowering effect induced by the hyperlipidemia leucomisine when, like nicotinic acid, may be due to an inhibitory effect on lipolysis in adipose tissue. Along with this leucomisine has an antioxidant effect due to the activation of enzymes antiperoxidant protect and increase the redox potential of glutathione in the liver of rats.https://bulletin.ssmu.ru/jour/article/view/9гиперлипидемияэтанол, леукомизинникотиновая кислоталиполизантиперекисная защита |
| spellingShingle | E. A. Rodnova V. V. Ivanov S. I. Ledyukova V. S. Chuchalin A. V. Ratkin B. B. Rakhimova I. A. Khabarov S. M. Adekenov HYPOLIPIDEMIC EFFECT LEUCOMISINE MODEL OF ACUTE HYPERLIPIDEMIA INDUCED BY ETHANOL Бюллетень сибирской медицины гиперлипидемия этанол, леукомизин никотиновая кислота липолиз антиперекисная защита |
| title | HYPOLIPIDEMIC EFFECT LEUCOMISINE MODEL OF ACUTE HYPERLIPIDEMIA INDUCED BY ETHANOL |
| title_full | HYPOLIPIDEMIC EFFECT LEUCOMISINE MODEL OF ACUTE HYPERLIPIDEMIA INDUCED BY ETHANOL |
| title_fullStr | HYPOLIPIDEMIC EFFECT LEUCOMISINE MODEL OF ACUTE HYPERLIPIDEMIA INDUCED BY ETHANOL |
| title_full_unstemmed | HYPOLIPIDEMIC EFFECT LEUCOMISINE MODEL OF ACUTE HYPERLIPIDEMIA INDUCED BY ETHANOL |
| title_short | HYPOLIPIDEMIC EFFECT LEUCOMISINE MODEL OF ACUTE HYPERLIPIDEMIA INDUCED BY ETHANOL |
| title_sort | hypolipidemic effect leucomisine model of acute hyperlipidemia induced by ethanol |
| topic | гиперлипидемия этанол, леукомизин никотиновая кислота липолиз антиперекисная защита |
| url | https://bulletin.ssmu.ru/jour/article/view/9 |
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