Effects of Magnesium Sulfate on Pain, Nausea/Vomiting, and Anesthetic Consumption after Corneal Transplantation and Vitrectomy
Background: Pain and postoperative nausea/vomiting (PONV) are of the most frequent complications after major ophthalmologic surgeries, and there is no general agreement on the effective method of controlling them. We compared the effects of magnesium sulfate on pain, nausea/vomiting, and anesthetic...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2017-05-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/6894 |
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| author | Mojtaba Rahimi-Varposhti Darioush Moradi-Farsani Aneseh Salehnia Kamran Montazeri Amir Shafa |
| author_facet | Mojtaba Rahimi-Varposhti Darioush Moradi-Farsani Aneseh Salehnia Kamran Montazeri Amir Shafa |
| author_sort | Mojtaba Rahimi-Varposhti |
| collection | DOAJ |
| description | Background: Pain and postoperative nausea/vomiting (PONV) are of the most frequent complications after major ophthalmologic surgeries, and there is no general agreement on the effective method of controlling them. We compared the effects of magnesium sulfate on pain, nausea/vomiting, and anesthetic and analgesic requirement after corneal transplantation and vitrectomy surgeries.
Methods: 110 patients undergoing corneal transplantation and vitrectomy under the same manner of general anesthesia were distributed into two equal groups. In the first group, magnesium sulfate (50 mg/kg) was administered during 10 minutes just before induction of anesthesia, and then during the surgery (15 mg/kg/hour). In the placebo group, normal saline was prescribed in the same way. Information concerning the pain (visual analog scale or VAS) and nausea/vomiting, total anesthetic and additional opioid consumption, and patients' hemodynamic status was collected and compared.
Findings: The mean intensity of pain and nausea were significantly lower in magnesium sulfate group compared to placebo group in the all periods during the study (pain: 1.8 and 2.8, respectively, P = 0.020; nausea: 0.35 and 1.1, respectively, P = 0.020). But, there were no significant difference in the incidence of vomiting (P = 0.500) and total doses of ondansetrone and pethidine consumption among the two groups (P > 0.050).
Conclusion: Magnesium sulfate administration is more effective than placebo to reduce anesthetic consumption, pain, and nausea/vomiting after corneal transplantation and vitrectomy. |
| first_indexed | 2024-03-12T20:01:15Z |
| format | Article |
| id | doaj.art-d43f7c3446994b6a9abf51d07a03e81c |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T20:01:15Z |
| publishDate | 2017-05-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-d43f7c3446994b6a9abf51d07a03e81c2023-08-02T02:26:01ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2017-05-01354232782842470Effects of Magnesium Sulfate on Pain, Nausea/Vomiting, and Anesthetic Consumption after Corneal Transplantation and VitrectomyMojtaba Rahimi-Varposhti0Darioush Moradi-Farsani1Aneseh Salehnia2Kamran Montazeri3Amir Shafa4Associate Professor, Anesthesiology and Critical Care Research Center AND Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Anesthesiology and Critical Care Research Center AND Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranProfessor, Anesthesiology and Critical Care Research Center AND Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Anesthesiology and Critical Care Research Center AND Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Pain and postoperative nausea/vomiting (PONV) are of the most frequent complications after major ophthalmologic surgeries, and there is no general agreement on the effective method of controlling them. We compared the effects of magnesium sulfate on pain, nausea/vomiting, and anesthetic and analgesic requirement after corneal transplantation and vitrectomy surgeries. Methods: 110 patients undergoing corneal transplantation and vitrectomy under the same manner of general anesthesia were distributed into two equal groups. In the first group, magnesium sulfate (50 mg/kg) was administered during 10 minutes just before induction of anesthesia, and then during the surgery (15 mg/kg/hour). In the placebo group, normal saline was prescribed in the same way. Information concerning the pain (visual analog scale or VAS) and nausea/vomiting, total anesthetic and additional opioid consumption, and patients' hemodynamic status was collected and compared. Findings: The mean intensity of pain and nausea were significantly lower in magnesium sulfate group compared to placebo group in the all periods during the study (pain: 1.8 and 2.8, respectively, P = 0.020; nausea: 0.35 and 1.1, respectively, P = 0.020). But, there were no significant difference in the incidence of vomiting (P = 0.500) and total doses of ondansetrone and pethidine consumption among the two groups (P > 0.050). Conclusion: Magnesium sulfate administration is more effective than placebo to reduce anesthetic consumption, pain, and nausea/vomiting after corneal transplantation and vitrectomy.http://jims.mui.ac.ir/index.php/jims/article/view/6894Corneal transplantationMagnesium sulfatePainNauseaVitrectomy |
| spellingShingle | Mojtaba Rahimi-Varposhti Darioush Moradi-Farsani Aneseh Salehnia Kamran Montazeri Amir Shafa Effects of Magnesium Sulfate on Pain, Nausea/Vomiting, and Anesthetic Consumption after Corneal Transplantation and Vitrectomy مجله دانشکده پزشکی اصفهان Corneal transplantation Magnesium sulfate Pain Nausea Vitrectomy |
| title | Effects of Magnesium Sulfate on Pain, Nausea/Vomiting, and Anesthetic Consumption after Corneal Transplantation and Vitrectomy |
| title_full | Effects of Magnesium Sulfate on Pain, Nausea/Vomiting, and Anesthetic Consumption after Corneal Transplantation and Vitrectomy |
| title_fullStr | Effects of Magnesium Sulfate on Pain, Nausea/Vomiting, and Anesthetic Consumption after Corneal Transplantation and Vitrectomy |
| title_full_unstemmed | Effects of Magnesium Sulfate on Pain, Nausea/Vomiting, and Anesthetic Consumption after Corneal Transplantation and Vitrectomy |
| title_short | Effects of Magnesium Sulfate on Pain, Nausea/Vomiting, and Anesthetic Consumption after Corneal Transplantation and Vitrectomy |
| title_sort | effects of magnesium sulfate on pain nausea vomiting and anesthetic consumption after corneal transplantation and vitrectomy |
| topic | Corneal transplantation Magnesium sulfate Pain Nausea Vitrectomy |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/6894 |
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