Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study)
The aim of this work is to evaluate the immunohistochemical expression of PD-L1 in tumor cells of urothelial bladder carcinoma. PD-L1 immunoexpression was assessed on 20 cases of radical cystectomy specimens using monoclonal rabbit anti- PD-L1 antibody. Extent of membranous PD-L1 expression was ass...
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| Format: | Article |
| Language: | English |
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Beni-Suef University, Faculty of Medicine
2021-06-01
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| Series: | Egyptian Journal of Medical Research |
| Subjects: | |
| Online Access: | https://ejmr.journals.ekb.eg/article_175727_65886dbe73664614a6f8c2d24ba8efbc.pdf |
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| author | Nadia Ahmed Abd El-Moeze Marwa Mohamed Sayed Amr Medht Masoud Samira AbdAllah Mahmoud Wesam Ismail Moustafa |
| author_facet | Nadia Ahmed Abd El-Moeze Marwa Mohamed Sayed Amr Medht Masoud Samira AbdAllah Mahmoud Wesam Ismail Moustafa |
| author_sort | Nadia Ahmed Abd El-Moeze |
| collection | DOAJ |
| description | The aim of this work is to evaluate the immunohistochemical expression of PD-L1 in tumor cells of urothelial bladder carcinoma. PD-L1 immunoexpression was assessed on 20 cases of radical cystectomy specimens using monoclonal rabbit anti- PD-L1 antibody. Extent of membranous PD-L1 expression was assigned in each case. Tumor cells showing > 5% expression were considered positive. PD-L1was seen in 6 (30%) cases [1 case score +2 and 5 cases score +3], while 14(70%) cases were negative [7 cases score 0 and 7 cases score +1]. PD-L1 expression in tumor cells was insignificantly correlated with different available clinicopathological parameters such as sex, pathological stage, associatedbilharzial infestation, necrosis, perineural invasion and associated tumor infiltrating mononuclear cells (TIMCs), although PD-L1 positivity tend to predominate in advanced pathological stage of tumor (T3 and T4). These findings may have clinical implications for the management of patients with PD-L1 positive urothelial bladder carcinoma. |
| first_indexed | 2024-04-10T07:02:08Z |
| format | Article |
| id | doaj.art-d43fa099dd30466ea3e6735ebfe12c36 |
| institution | Directory Open Access Journal |
| issn | 2682-4396 2682-440X |
| language | English |
| last_indexed | 2024-04-10T07:02:08Z |
| publishDate | 2021-06-01 |
| publisher | Beni-Suef University, Faculty of Medicine |
| record_format | Article |
| series | Egyptian Journal of Medical Research |
| spelling | doaj.art-d43fa099dd30466ea3e6735ebfe12c362023-02-27T17:41:47ZengBeni-Suef University, Faculty of MedicineEgyptian Journal of Medical Research2682-43962682-440X2021-06-012225026110.21608/ejmr.2021.175727175727Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study)Nadia Ahmed Abd El-Moeze0Marwa Mohamed Sayed1Amr Medht Masoud2Samira AbdAllah Mahmoud3Wesam Ismail Moustafa4Pathology department, Faculty of medicine, Beni- Suef University, Beni-Suef, 62514, EgyptPathology department, Faculty of medicine, Beni- Suef University, Beni-Suef, 62514, EgyptUrology department, Faculty of medicine, Beni- Suef University, Beni-Suef, 62514, EgyptPathology department, Faculty of medicine, Cairo University, Cairo, 11865, EgyptPathology department, Faculty of medicine, Beni- Suef University, Beni-Suef, 62514, EgyptThe aim of this work is to evaluate the immunohistochemical expression of PD-L1 in tumor cells of urothelial bladder carcinoma. PD-L1 immunoexpression was assessed on 20 cases of radical cystectomy specimens using monoclonal rabbit anti- PD-L1 antibody. Extent of membranous PD-L1 expression was assigned in each case. Tumor cells showing > 5% expression were considered positive. PD-L1was seen in 6 (30%) cases [1 case score +2 and 5 cases score +3], while 14(70%) cases were negative [7 cases score 0 and 7 cases score +1]. PD-L1 expression in tumor cells was insignificantly correlated with different available clinicopathological parameters such as sex, pathological stage, associatedbilharzial infestation, necrosis, perineural invasion and associated tumor infiltrating mononuclear cells (TIMCs), although PD-L1 positivity tend to predominate in advanced pathological stage of tumor (T3 and T4). These findings may have clinical implications for the management of patients with PD-L1 positive urothelial bladder carcinoma.https://ejmr.journals.ekb.eg/article_175727_65886dbe73664614a6f8c2d24ba8efbc.pdfpdl-1ubcimmunohistochemistry |
| spellingShingle | Nadia Ahmed Abd El-Moeze Marwa Mohamed Sayed Amr Medht Masoud Samira AbdAllah Mahmoud Wesam Ismail Moustafa Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study) Egyptian Journal of Medical Research pdl-1 ubc immunohistochemistry |
| title | Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study) |
| title_full | Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study) |
| title_fullStr | Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study) |
| title_full_unstemmed | Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study) |
| title_short | Expression of programmed death ligand 1 (PD-L1) in urothelial bladder carcinoma (immunohistochemical and histopathological study) |
| title_sort | expression of programmed death ligand 1 pd l1 in urothelial bladder carcinoma immunohistochemical and histopathological study |
| topic | pdl-1 ubc immunohistochemistry |
| url | https://ejmr.journals.ekb.eg/article_175727_65886dbe73664614a6f8c2d24ba8efbc.pdf |
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