Cytokinesis in Eukaryotic Cells: The Furrow Complexity at a Glance
The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signali...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/2/271 |
| _version_ | 1797764069806047232 |
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| author | Roberta Fraschini |
| author_facet | Roberta Fraschini |
| author_sort | Roberta Fraschini |
| collection | DOAJ |
| description | The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the steps of cell division must be properly coordinated with each other to faithfully segregate the genetic material and this task is fundamental for generating viable cells. Given the importance of this process, molecular pathways and proteins that are involved in cytokinesis are conserved from yeast to humans. In this review, we describe symmetric and asymmetric cell division in animal cell and in a model organism, budding yeast. In addition, we illustrate the surveillance mechanisms that ensure a proper cell division and discuss the connections with normal cell proliferation and organs development and with the occurrence of human diseases. |
| first_indexed | 2024-03-12T19:51:26Z |
| format | Article |
| id | doaj.art-d4423b7c903c4825b71c2d1ccf5c70a8 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T19:51:26Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d4423b7c903c4825b71c2d1ccf5c70a82023-08-02T03:12:41ZengMDPI AGCells2073-44092020-01-019227110.3390/cells9020271cells9020271Cytokinesis in Eukaryotic Cells: The Furrow Complexity at a GlanceRoberta Fraschini0Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, ItalyThe duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the steps of cell division must be properly coordinated with each other to faithfully segregate the genetic material and this task is fundamental for generating viable cells. Given the importance of this process, molecular pathways and proteins that are involved in cytokinesis are conserved from yeast to humans. In this review, we describe symmetric and asymmetric cell division in animal cell and in a model organism, budding yeast. In addition, we illustrate the surveillance mechanisms that ensure a proper cell division and discuss the connections with normal cell proliferation and organs development and with the occurrence of human diseases.https://www.mdpi.com/2073-4409/9/2/271cell divisionaneuploidymen networkbud neckmodel organismtetraploidycin |
| spellingShingle | Roberta Fraschini Cytokinesis in Eukaryotic Cells: The Furrow Complexity at a Glance Cells cell division aneuploidy men network bud neck model organism tetraploidy cin |
| title | Cytokinesis in Eukaryotic Cells: The Furrow Complexity at a Glance |
| title_full | Cytokinesis in Eukaryotic Cells: The Furrow Complexity at a Glance |
| title_fullStr | Cytokinesis in Eukaryotic Cells: The Furrow Complexity at a Glance |
| title_full_unstemmed | Cytokinesis in Eukaryotic Cells: The Furrow Complexity at a Glance |
| title_short | Cytokinesis in Eukaryotic Cells: The Furrow Complexity at a Glance |
| title_sort | cytokinesis in eukaryotic cells the furrow complexity at a glance |
| topic | cell division aneuploidy men network bud neck model organism tetraploidy cin |
| url | https://www.mdpi.com/2073-4409/9/2/271 |
| work_keys_str_mv | AT robertafraschini cytokinesisineukaryoticcellsthefurrowcomplexityataglance |