People with diabetes and hypovitaminosis C fail to conserve urinary vitamin C
Background: Hypovitaminosis C has negative health consequences. People with diabetes and hypovitaminosis C may fail to conserve vitamin C in the urine, thereby displaying evidence of inappropriate renal leak of vitamin C. This study describes the relationship between plasma and urinary vitamin C in...
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Format: | Article |
Language: | English |
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Elsevier
2023-03-01
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Series: | Journal of Clinical & Translational Endocrinology |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2214623723000042 |
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author | Helen Lunt Anitra C Carr Helen F Heenan Emma Vlasiuk Masuma Zawari Tim Prickett Chris Frampton |
author_facet | Helen Lunt Anitra C Carr Helen F Heenan Emma Vlasiuk Masuma Zawari Tim Prickett Chris Frampton |
author_sort | Helen Lunt |
collection | DOAJ |
description | Background: Hypovitaminosis C has negative health consequences. People with diabetes and hypovitaminosis C may fail to conserve vitamin C in the urine, thereby displaying evidence of inappropriate renal leak of vitamin C. This study describes the relationship between plasma and urinary vitamin C in diabetes, with a focus on the clinical characteristics of participants with renal leak. Methods: Retrospective analysis of paired, non-fasting plasma and urine vitamin C, and also clinical characteristics, from participants with either type 1 or type 2 diabetes, recruited from a secondary care diabetes clinic. Plasma vitamin C thresholds for renal leak have been defined previously as 38.1 µmol/L for men and 43.2 µmol/L for women. Results: Statistically significant differences in clinical characteristics were seen between those with; i) renal leak (N = 77) and; ii) hypovitaminosis C but no renal leak (N = 13) and; iii) normal plasma vitamin C levels (n = 34). Compared to participants with adequate plasma vitamin C levels, participants with renal leak tended to have type 2 (rather than type 1) diabetes, a lower eGFR and a higher HbA1c. Conclusion: In the diabetes population studied, renal leak of vitamin C was common. In some participants, it may have contributed to hypovitaminosis C. |
first_indexed | 2024-04-10T00:30:17Z |
format | Article |
id | doaj.art-d44488ccaf7744c08100d4a75f3e4be3 |
institution | Directory Open Access Journal |
issn | 2214-6237 |
language | English |
last_indexed | 2024-04-10T00:30:17Z |
publishDate | 2023-03-01 |
publisher | Elsevier |
record_format | Article |
series | Journal of Clinical & Translational Endocrinology |
spelling | doaj.art-d44488ccaf7744c08100d4a75f3e4be32023-03-15T04:28:14ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372023-03-0131100316People with diabetes and hypovitaminosis C fail to conserve urinary vitamin CHelen Lunt0Anitra C Carr1Helen F Heenan2Emma Vlasiuk3Masuma Zawari4Tim Prickett5Chris Frampton6Diabetes Outpatients, Te Whatu Ora Waitaha Canterbury, Christchurch 8011, New Zealand; Department of Medicine, University of Otago, Christchurch. 2 Riccarton Ave, Christchurch 8011, New Zealand; Corresponding author at: Diabetes Outpatients, Te Whatu Ora Waitaha Canterbury, Christchurch 8011, New Zealand.Nutrition in Medicine Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch. 2 Riccarton Ave, Christchurch 8011, New ZealandDiabetes Outpatients, Te Whatu Ora Waitaha Canterbury, Christchurch 8011, New ZealandNutrition in Medicine Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch. 2 Riccarton Ave, Christchurch 8011, New ZealandNutrition in Medicine Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch. 2 Riccarton Ave, Christchurch 8011, New ZealandDepartment of Medicine, University of Otago, Christchurch. 2 Riccarton Ave, Christchurch 8011, New ZealandDepartment of Medicine, University of Otago, Christchurch. 2 Riccarton Ave, Christchurch 8011, New ZealandBackground: Hypovitaminosis C has negative health consequences. People with diabetes and hypovitaminosis C may fail to conserve vitamin C in the urine, thereby displaying evidence of inappropriate renal leak of vitamin C. This study describes the relationship between plasma and urinary vitamin C in diabetes, with a focus on the clinical characteristics of participants with renal leak. Methods: Retrospective analysis of paired, non-fasting plasma and urine vitamin C, and also clinical characteristics, from participants with either type 1 or type 2 diabetes, recruited from a secondary care diabetes clinic. Plasma vitamin C thresholds for renal leak have been defined previously as 38.1 µmol/L for men and 43.2 µmol/L for women. Results: Statistically significant differences in clinical characteristics were seen between those with; i) renal leak (N = 77) and; ii) hypovitaminosis C but no renal leak (N = 13) and; iii) normal plasma vitamin C levels (n = 34). Compared to participants with adequate plasma vitamin C levels, participants with renal leak tended to have type 2 (rather than type 1) diabetes, a lower eGFR and a higher HbA1c. Conclusion: In the diabetes population studied, renal leak of vitamin C was common. In some participants, it may have contributed to hypovitaminosis C.http://www.sciencedirect.com/science/article/pii/S2214623723000042DiabetesDiabetic nephropathyVitamin C deficiencyPhysiopathologyNutritional and metabolic diseasesUrine |
spellingShingle | Helen Lunt Anitra C Carr Helen F Heenan Emma Vlasiuk Masuma Zawari Tim Prickett Chris Frampton People with diabetes and hypovitaminosis C fail to conserve urinary vitamin C Journal of Clinical & Translational Endocrinology Diabetes Diabetic nephropathy Vitamin C deficiency Physiopathology Nutritional and metabolic diseases Urine |
title | People with diabetes and hypovitaminosis C fail to conserve urinary vitamin C |
title_full | People with diabetes and hypovitaminosis C fail to conserve urinary vitamin C |
title_fullStr | People with diabetes and hypovitaminosis C fail to conserve urinary vitamin C |
title_full_unstemmed | People with diabetes and hypovitaminosis C fail to conserve urinary vitamin C |
title_short | People with diabetes and hypovitaminosis C fail to conserve urinary vitamin C |
title_sort | people with diabetes and hypovitaminosis c fail to conserve urinary vitamin c |
topic | Diabetes Diabetic nephropathy Vitamin C deficiency Physiopathology Nutritional and metabolic diseases Urine |
url | http://www.sciencedirect.com/science/article/pii/S2214623723000042 |
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