Autoimmune thyroiditis associated with neuromyelitis optica (NMO)
Neuromyelitis optica (NMO or Devic’s syndrome) is a rare relapsing demyelinating disease of the central nervous system (CNS) that mainly affects the spinal cord and optic nerves and shares many clinical and radiological features with multiple sclerosis. The association of NMO with other autoimmune...
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| Format: | Article |
| Language: | deu |
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German Medical Science GMS Publishing House
2015-11-01
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| Series: | GMS German Medical Science |
| Subjects: | |
| Online Access: | http://www.egms.de/static/en/journals/gms/2015-13/000226.shtml |
| _version_ | 1819150253853507584 |
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| author | Sudulagunta, Sreenivasa Rao Sodalagunta, Mahesh Babu Khorram, Hadi Sepehrar, Mona Gonivada, Jayadevappa Noroozpour, Zahra Prasad, Nagendra |
| author_facet | Sudulagunta, Sreenivasa Rao Sodalagunta, Mahesh Babu Khorram, Hadi Sepehrar, Mona Gonivada, Jayadevappa Noroozpour, Zahra Prasad, Nagendra |
| author_sort | Sudulagunta, Sreenivasa Rao |
| collection | DOAJ |
| description | Neuromyelitis optica (NMO or Devic’s syndrome) is a rare relapsing demyelinating disease of the central nervous system (CNS) that mainly affects the spinal cord and optic nerves and shares many clinical and radiological features with multiple sclerosis. The association of NMO with other autoimmune diseases was reported, but very few reports described association with autoimmune thyroid disease. Early differentiation between NMO and multiple sclerosis is very important as the natural course and treatment regimens differ significantly. We report a case of a 50-year-old woman who was admitted initially with vomiting, hiccups and paraesthesias but was not diagnosed with NMO and presented with a severe progression of the disease. The patient was also diagnosed to have autoimmune thyroiditis with lymphocytic infiltration of the thyroid which progressed from hyperthyroidism to hypothyroidism. NMO diagnosis was established with seropositivity for NMO-IgG and MRI showing longitudinally extensive spinal cord lesions (3 or more spinal segments). In spite of treatment, the response was poor due to lack of early diagnosis and aggressive immunosuppressant therapy. |
| first_indexed | 2024-12-22T14:14:34Z |
| format | Article |
| id | doaj.art-d445111193ac499683008250c49e4fc1 |
| institution | Directory Open Access Journal |
| issn | 1612-3174 |
| language | deu |
| last_indexed | 2024-12-22T14:14:34Z |
| publishDate | 2015-11-01 |
| publisher | German Medical Science GMS Publishing House |
| record_format | Article |
| series | GMS German Medical Science |
| spelling | doaj.art-d445111193ac499683008250c49e4fc12022-12-21T18:23:09ZdeuGerman Medical Science GMS Publishing HouseGMS German Medical Science1612-31742015-11-0113Doc2210.3205/000226Autoimmune thyroiditis associated with neuromyelitis optica (NMO)Sudulagunta, Sreenivasa Rao0Sodalagunta, Mahesh Babu1Khorram, Hadi2Sepehrar, Mona3Gonivada, Jayadevappa4Noroozpour, Zahra5Prasad, Nagendra6Columbia Asia Hospital, Bangalore, IndiaK.S. Hegde Medical College, Mangalore, IndiaDr.B.R. Ambedkar Medical College, Otolaryngology Department, Bangalore, IndiaBaptist Hospital, Bangalore, IndiaDr.B.R. Ambedkar Medical College, Bangalore, IndiaColumbia Asia Hospital, Bangalore, IndiaDr.B.R. Ambedkar Medical College, Bangalore, IndiaNeuromyelitis optica (NMO or Devic’s syndrome) is a rare relapsing demyelinating disease of the central nervous system (CNS) that mainly affects the spinal cord and optic nerves and shares many clinical and radiological features with multiple sclerosis. The association of NMO with other autoimmune diseases was reported, but very few reports described association with autoimmune thyroid disease. Early differentiation between NMO and multiple sclerosis is very important as the natural course and treatment regimens differ significantly. We report a case of a 50-year-old woman who was admitted initially with vomiting, hiccups and paraesthesias but was not diagnosed with NMO and presented with a severe progression of the disease. The patient was also diagnosed to have autoimmune thyroiditis with lymphocytic infiltration of the thyroid which progressed from hyperthyroidism to hypothyroidism. NMO diagnosis was established with seropositivity for NMO-IgG and MRI showing longitudinally extensive spinal cord lesions (3 or more spinal segments). In spite of treatment, the response was poor due to lack of early diagnosis and aggressive immunosuppressant therapy.http://www.egms.de/static/en/journals/gms/2015-13/000226.shtmlneuromyelitis optica (NMO)optic neuritistransverse myelitisIgGautoimmune thyroiditis |
| spellingShingle | Sudulagunta, Sreenivasa Rao Sodalagunta, Mahesh Babu Khorram, Hadi Sepehrar, Mona Gonivada, Jayadevappa Noroozpour, Zahra Prasad, Nagendra Autoimmune thyroiditis associated with neuromyelitis optica (NMO) GMS German Medical Science neuromyelitis optica (NMO) optic neuritis transverse myelitis IgG autoimmune thyroiditis |
| title | Autoimmune thyroiditis associated with neuromyelitis optica (NMO) |
| title_full | Autoimmune thyroiditis associated with neuromyelitis optica (NMO) |
| title_fullStr | Autoimmune thyroiditis associated with neuromyelitis optica (NMO) |
| title_full_unstemmed | Autoimmune thyroiditis associated with neuromyelitis optica (NMO) |
| title_short | Autoimmune thyroiditis associated with neuromyelitis optica (NMO) |
| title_sort | autoimmune thyroiditis associated with neuromyelitis optica nmo |
| topic | neuromyelitis optica (NMO) optic neuritis transverse myelitis IgG autoimmune thyroiditis |
| url | http://www.egms.de/static/en/journals/gms/2015-13/000226.shtml |
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