Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control

Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control

Abstract p38 mitogen-activated protein kinases (MAPKs) participate in autophagic signaling; and previous reports suggest that pyridinyl imidazole p38 MAPK inhibitors, including SB203580 and SB202190, induce cell death in some cancer cell-types through unrestrained autophagy. Subsequent studies, howe...

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Bibliographic Details
Main Authors: Daric J. Wible, Zalak Parikh, Eun Jeong Cho, Miao-Der Chen, Collene R. Jeter, Somshuvra Mukhopadhyay, Kevin N. Dalby, Shankar Varadarajan, Shawn B. Bratton
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06423-0

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