Combined test of serum CgA and NSE improved the power of prognosis prediction of NF-pNETs
Purpose: Chromogranin A (CgA) and neuron-specific enolase (NSE) are important markers for neuroendocrine tumors; however, the clinical value of combining these markers has not been well studied. In this study, we investigated the utility of each marker individually and in combination for patients...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2018-01-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | http://www.endocrineconnections.com/content/7/1/169.full |
| _version_ | 1818422990968193024 |
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| author | Yang Lv Xu Han Chunyan Zhang Yuan Fang Ning Pu Yuan Ji Xuefeng Xu Wenhui Lou Dansong Wang |
| author_facet | Yang Lv Xu Han Chunyan Zhang Yuan Fang Ning Pu Yuan Ji Xuefeng Xu Wenhui Lou Dansong Wang |
| author_sort | Yang Lv |
| collection | DOAJ |
| description | Purpose: Chromogranin A (CgA) and neuron-specific enolase (NSE) are important
markers for neuroendocrine tumors; however, the clinical value of combining these
markers has not been well studied. In this study, we investigated the utility of each
marker individually and in combination for patients with nonfunctional pancreatic
neuroendocrine tumors (NF-pNETs).
Patients and Methods: In this study, NF-pNET patients and controls were recruited from
December 2011 to March 2016; 784 serum samples from peripheral vein were collected.
The clinical characteristics and biomarker values of all the individuals were recorded
and analyzed. Tumor burdens were calculated by CT/MRI scan. Receiver-operating
characteristic curves were constructed to assess the diagnostic predictive values;
sensitivity and specificity were calculated to determine the cut-off value. Therapeutic
responses reflected on the changes of the biomarkers’ concentration were assessed by
the RECIST criterion. Clinical relations between the prognosis and the biomarker values
were also analyzed. Statistical significance was defined as P value less than 0.05.
Results: Among the 167 NF-pNETs patients, 82 were males (49.1%) and the mean age
was 50.0 (17.4). The mean CgA values of G1, G2 and G3 NF-pNENs were 75, 121 and
134 μg/L (P < 0.05), respectively. In NF-pNETs, CgA correlated with the WHO tumor grade
(WHO G1 vs G2, P < 0.05); the linear regression relationships were found between the
tumor burdens (both in pancreas and liver) and CgA concentration (P < 0.001); changes in
CgA and NSE concentrations also reflect treatment response (P < 0.001).
Conclusion: CgA and NSE are important diagnostic and follow-up markers in patients
with NF-pNETs. The combined monitoring of CgA and NSE possesses more accuracy than
individual values of CgA and NSE at predicting prognosis and disease progression. |
| first_indexed | 2024-12-14T13:35:02Z |
| format | Article |
| id | doaj.art-d445fba21a9b42f08ba30afd9ce04365 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-14T13:35:02Z |
| publishDate | 2018-01-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-d445fba21a9b42f08ba30afd9ce043652022-12-21T22:59:36ZengBioscientificaEndocrine Connections2049-36142049-36142018-01-017116917810.1530/EC-17-0276Combined test of serum CgA and NSE improved the power of prognosis prediction of NF-pNETsYang Lv0Xu Han1Chunyan Zhang2Yuan Fang3Ning Pu4Yuan Ji5Xuefeng Xu6Wenhui Lou7Dansong Wang8Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaPurpose: Chromogranin A (CgA) and neuron-specific enolase (NSE) are important markers for neuroendocrine tumors; however, the clinical value of combining these markers has not been well studied. In this study, we investigated the utility of each marker individually and in combination for patients with nonfunctional pancreatic neuroendocrine tumors (NF-pNETs). Patients and Methods: In this study, NF-pNET patients and controls were recruited from December 2011 to March 2016; 784 serum samples from peripheral vein were collected. The clinical characteristics and biomarker values of all the individuals were recorded and analyzed. Tumor burdens were calculated by CT/MRI scan. Receiver-operating characteristic curves were constructed to assess the diagnostic predictive values; sensitivity and specificity were calculated to determine the cut-off value. Therapeutic responses reflected on the changes of the biomarkers’ concentration were assessed by the RECIST criterion. Clinical relations between the prognosis and the biomarker values were also analyzed. Statistical significance was defined as P value less than 0.05. Results: Among the 167 NF-pNETs patients, 82 were males (49.1%) and the mean age was 50.0 (17.4). The mean CgA values of G1, G2 and G3 NF-pNENs were 75, 121 and 134 μg/L (P < 0.05), respectively. In NF-pNETs, CgA correlated with the WHO tumor grade (WHO G1 vs G2, P < 0.05); the linear regression relationships were found between the tumor burdens (both in pancreas and liver) and CgA concentration (P < 0.001); changes in CgA and NSE concentrations also reflect treatment response (P < 0.001). Conclusion: CgA and NSE are important diagnostic and follow-up markers in patients with NF-pNETs. The combined monitoring of CgA and NSE possesses more accuracy than individual values of CgA and NSE at predicting prognosis and disease progression.http://www.endocrineconnections.com/content/7/1/169.fullchromogranin Aneuron-specific enolasenonfunctioning pancreatic neuroendocrine tumorsprognosis prediction |
| spellingShingle | Yang Lv Xu Han Chunyan Zhang Yuan Fang Ning Pu Yuan Ji Xuefeng Xu Wenhui Lou Dansong Wang Combined test of serum CgA and NSE improved the power of prognosis prediction of NF-pNETs Endocrine Connections chromogranin A neuron-specific enolase nonfunctioning pancreatic neuroendocrine tumors prognosis prediction |
| title | Combined test of serum CgA and NSE improved the power of prognosis prediction of NF-pNETs |
| title_full | Combined test of serum CgA and NSE improved the power of prognosis prediction of NF-pNETs |
| title_fullStr | Combined test of serum CgA and NSE improved the power of prognosis prediction of NF-pNETs |
| title_full_unstemmed | Combined test of serum CgA and NSE improved the power of prognosis prediction of NF-pNETs |
| title_short | Combined test of serum CgA and NSE improved the power of prognosis prediction of NF-pNETs |
| title_sort | combined test of serum cga and nse improved the power of prognosis prediction of nf pnets |
| topic | chromogranin A neuron-specific enolase nonfunctioning pancreatic neuroendocrine tumors prognosis prediction |
| url | http://www.endocrineconnections.com/content/7/1/169.full |
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