Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates
Abstract INTRODUCTION The relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated. METHODS Thirty isolates were used to determine the mucoid aspect. Four were selecte...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2019-04-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100648&lng=en&tlng=en |
| _version_ | 1817977137556094976 |
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| author | Francinete Carla Nunes Cavalcanti Juliana Falcão Rodrigues Adriane Borges Cabral Larissa Caina Barbosa de Azarias Marcos Antônio de Morais Júnior Célia Maria Machado Barbosa de Castro Ana Catarina de Souza Lopes |
| author_facet | Francinete Carla Nunes Cavalcanti Juliana Falcão Rodrigues Adriane Borges Cabral Larissa Caina Barbosa de Azarias Marcos Antônio de Morais Júnior Célia Maria Machado Barbosa de Castro Ana Catarina de Souza Lopes |
| author_sort | Francinete Carla Nunes Cavalcanti |
| collection | DOAJ |
| description | Abstract INTRODUCTION The relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated. METHODS Thirty isolates were used to determine the mucoid aspect. Four were selected for analysis of phagocytosis by alveolar macrophages. RESULTS Thirty percent of the samples presented the mucoid phenotype. The phagocytosis rate ranged from 21.5% to 43.43%. Phagocytosis was not correlated with the plasmid profile, but was apparently correlated with mucoid phenotype and antibiotic susceptibility. CONCLUSIONS: Several virulence factors act in parallel in K. pneumoniae to impair host defense. |
| first_indexed | 2024-04-13T22:12:15Z |
| format | Article |
| id | doaj.art-d4479f651d4c42758a9695de926311a8 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T22:12:15Z |
| publishDate | 2019-04-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-d4479f651d4c42758a9695de926311a82022-12-22T02:27:42ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492019-04-0152010.1590/0037-8682-0089-2019S0037-86822019000100648Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolatesFrancinete Carla Nunes CavalcantiJuliana Falcão RodriguesAdriane Borges CabralLarissa Caina Barbosa de AzariasMarcos Antônio de Morais JúniorCélia Maria Machado Barbosa de CastroAna Catarina de Souza LopesAbstract INTRODUCTION The relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated. METHODS Thirty isolates were used to determine the mucoid aspect. Four were selected for analysis of phagocytosis by alveolar macrophages. RESULTS Thirty percent of the samples presented the mucoid phenotype. The phagocytosis rate ranged from 21.5% to 43.43%. Phagocytosis was not correlated with the plasmid profile, but was apparently correlated with mucoid phenotype and antibiotic susceptibility. CONCLUSIONS: Several virulence factors act in parallel in K. pneumoniae to impair host defense.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100648&lng=en&tlng=enKlebsiella pneumoniaeAlveolar macrophagesPhagocytosisMucoid phenotypeGenetic characteristics |
| spellingShingle | Francinete Carla Nunes Cavalcanti Juliana Falcão Rodrigues Adriane Borges Cabral Larissa Caina Barbosa de Azarias Marcos Antônio de Morais Júnior Célia Maria Machado Barbosa de Castro Ana Catarina de Souza Lopes Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates Revista da Sociedade Brasileira de Medicina Tropical Klebsiella pneumoniae Alveolar macrophages Phagocytosis Mucoid phenotype Genetic characteristics |
| title | Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates |
| title_full | Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates |
| title_fullStr | Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates |
| title_full_unstemmed | Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates |
| title_short | Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates |
| title_sort | relationships between phagocytosis mucoid phenotype and genetic characteristics of klebsiella pneumoniae clinical isolates |
| topic | Klebsiella pneumoniae Alveolar macrophages Phagocytosis Mucoid phenotype Genetic characteristics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100648&lng=en&tlng=en |
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