A Systematic Review and Meta-Analysis of Systemic and Local Antibiotic Therapy in the Surgical Treatment of Peri-Implantitis
(1) Background: Given the existing controversy regarding the use of antibiotics in the treatment of peri-implantitis, this systematic review and meta-analysis aim to ascertain how beneficial the role of systemic and local antibiotics is in peri-implant surgical therapy, considering the harmful effec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/7/1223 |
| _version_ | 1797590540258115584 |
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| author | María Baus-Domínguez Sara Bakkali Paula Hermida-Cabrera María-Angeles Serrera-Figallo José-Luis Gutiérrez-Pérez Daniel Torres-Lagares |
| author_facet | María Baus-Domínguez Sara Bakkali Paula Hermida-Cabrera María-Angeles Serrera-Figallo José-Luis Gutiérrez-Pérez Daniel Torres-Lagares |
| author_sort | María Baus-Domínguez |
| collection | DOAJ |
| description | (1) Background: Given the existing controversy regarding the use of antibiotics in the treatment of peri-implantitis, this systematic review and meta-analysis aim to ascertain how beneficial the role of systemic and local antibiotics is in peri-implant surgical therapy, considering the harmful effects that they represent and the abuse of antibiotics in terms of global health. (2) Methods: To determine the therapeutic efficacy of the administration of antibiotics in the surgical treatment of peri-implantitis in terms of probing pocket depth (PPD) and bleeding on probing (BoP), electronic and manual bibliographic searches were carried out in the Embase and PubMed databases, collecting data that related to before and after treatment. (3) Results: The adjunctive use of local antibiotics provides significant improvements in PPD (MD = 1.29; 95% CI: 0.56 to 2.02; <i>p</i> ≤ 0.0006; I<sup>2</sup> = 0%) when compared with surgical treatment alone. No significant differences were found in the other subgroup; that is, the use of systemic antibiotics did not significantly improve PPD changes in the surgical treatment of peri-implantitis (MD = 0.40; 95% CI: −0.15 to 0.95; <i>p</i> = 0.15; I<sup>2</sup> = 0). (4) Conclusions: The use of local antibiotics in the surgical treatment of peri-implantitis seems to offer treatment improvements in terms of PPD and BoP, unlike that observed with the use of systemic antibiotics. However, these results should be taken with caution as they also depend on the type of surgical technique used, whether regenerative or resective. More research is needed on this topic to understand the role of local and systemic antibiotics in the treatment of peri-implantitis. |
| first_indexed | 2024-03-11T01:21:58Z |
| format | Article |
| id | doaj.art-d44acdda8ae04c87b6b28a5d6a5dcddc |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T01:21:58Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-d44acdda8ae04c87b6b28a5d6a5dcddc2023-11-18T18:04:01ZengMDPI AGAntibiotics2079-63822023-07-01127122310.3390/antibiotics12071223A Systematic Review and Meta-Analysis of Systemic and Local Antibiotic Therapy in the Surgical Treatment of Peri-ImplantitisMaría Baus-Domínguez0Sara Bakkali1Paula Hermida-Cabrera2María-Angeles Serrera-Figallo3José-Luis Gutiérrez-Pérez4Daniel Torres-Lagares5Departamento de Estomatología, Facultad de Odontología, Universidad de Sevilla, 41009 Sevilla, SpainDepartamento de Estomatología, Facultad de Odontología, Universidad de Sevilla, 41009 Sevilla, SpainDepartamento de Estomatología, Facultad de Odontología, Universidad de Sevilla, 41009 Sevilla, SpainDepartamento de Estomatología, Facultad de Odontología, Universidad de Sevilla, 41009 Sevilla, SpainDepartamento de Estomatología, Facultad de Odontología, Universidad de Sevilla, 41009 Sevilla, SpainDepartamento de Estomatología, Facultad de Odontología, Universidad de Sevilla, 41009 Sevilla, Spain(1) Background: Given the existing controversy regarding the use of antibiotics in the treatment of peri-implantitis, this systematic review and meta-analysis aim to ascertain how beneficial the role of systemic and local antibiotics is in peri-implant surgical therapy, considering the harmful effects that they represent and the abuse of antibiotics in terms of global health. (2) Methods: To determine the therapeutic efficacy of the administration of antibiotics in the surgical treatment of peri-implantitis in terms of probing pocket depth (PPD) and bleeding on probing (BoP), electronic and manual bibliographic searches were carried out in the Embase and PubMed databases, collecting data that related to before and after treatment. (3) Results: The adjunctive use of local antibiotics provides significant improvements in PPD (MD = 1.29; 95% CI: 0.56 to 2.02; <i>p</i> ≤ 0.0006; I<sup>2</sup> = 0%) when compared with surgical treatment alone. No significant differences were found in the other subgroup; that is, the use of systemic antibiotics did not significantly improve PPD changes in the surgical treatment of peri-implantitis (MD = 0.40; 95% CI: −0.15 to 0.95; <i>p</i> = 0.15; I<sup>2</sup> = 0). (4) Conclusions: The use of local antibiotics in the surgical treatment of peri-implantitis seems to offer treatment improvements in terms of PPD and BoP, unlike that observed with the use of systemic antibiotics. However, these results should be taken with caution as they also depend on the type of surgical technique used, whether regenerative or resective. More research is needed on this topic to understand the role of local and systemic antibiotics in the treatment of peri-implantitis.https://www.mdpi.com/2079-6382/12/7/1223antibioticsprobing pocket depthbleeding on probingperi-implantitissurgical treatmentresective therapy |
| spellingShingle | María Baus-Domínguez Sara Bakkali Paula Hermida-Cabrera María-Angeles Serrera-Figallo José-Luis Gutiérrez-Pérez Daniel Torres-Lagares A Systematic Review and Meta-Analysis of Systemic and Local Antibiotic Therapy in the Surgical Treatment of Peri-Implantitis Antibiotics antibiotics probing pocket depth bleeding on probing peri-implantitis surgical treatment resective therapy |
| title | A Systematic Review and Meta-Analysis of Systemic and Local Antibiotic Therapy in the Surgical Treatment of Peri-Implantitis |
| title_full | A Systematic Review and Meta-Analysis of Systemic and Local Antibiotic Therapy in the Surgical Treatment of Peri-Implantitis |
| title_fullStr | A Systematic Review and Meta-Analysis of Systemic and Local Antibiotic Therapy in the Surgical Treatment of Peri-Implantitis |
| title_full_unstemmed | A Systematic Review and Meta-Analysis of Systemic and Local Antibiotic Therapy in the Surgical Treatment of Peri-Implantitis |
| title_short | A Systematic Review and Meta-Analysis of Systemic and Local Antibiotic Therapy in the Surgical Treatment of Peri-Implantitis |
| title_sort | systematic review and meta analysis of systemic and local antibiotic therapy in the surgical treatment of peri implantitis |
| topic | antibiotics probing pocket depth bleeding on probing peri-implantitis surgical treatment resective therapy |
| url | https://www.mdpi.com/2079-6382/12/7/1223 |
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