Benzimidazole Bearing Thiosemicarbazone Derivatives Act as Potent α-Amylase and α-Glucosidase Inhibitors; Synthesis, Bioactivity Screening and Molecular Docking Study

Benzimidazole Bearing Thiosemicarbazone Derivatives Act as Potent α-Amylase and α-Glucosidase Inhibitors; Synthesis, Bioactivity Screening and Molecular Docking Study

Diabetes mellitus is one of the most chronic metabolic diseases. In the past few years, our research group has synthesized and evaluated libraries of heterocyclic analogs against α-glucosidase and α-amylase enzymes and found encouraging results. The current study comprises the evaluation of benzimid...

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Bibliographic Details
Main Authors: Hayat Ullah, Shoaib Khan, Fazal Rahim, Muhammad Taha, Rashid Iqbal, Maliha Sarfraz, Syed Adnan Ali Shah, Muhammad Sajid, Mohamed F. Awad, Awatif Omran, Marzough Aziz Albalawi, Mahmoud A. Abdelaziz, Azza Al Areefy, Ibrahim Jafri
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
benzimidazole
thiosemicarbazone
synthesis
alpha-amylase
alpha-glucosidase
docking study
Online Access:https://www.mdpi.com/1420-3049/27/20/6921

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