Analysis of thyroid dysfunction in patients with sudden sensorineural hearing loss
Background: Sudden sensorineural hearing loss (SSHL) refers to the sudden occurrence of unexplained sensorineural hearing loss. The present study showed that different systemic diseases had different influence on the occurrence and hearing outcome of SSHL. Thyroid hormone is one of the important fac...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | World Journal of Otorhinolaryngology-Head and Neck Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095881119301003 |
| _version_ | 1828823235867705344 |
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| author | Yuhua Zhu Dan Bing Dayong Wang Lidong Zhao Zifang Yin Qiujing Zhang Jing Guan Qiuju Wang |
| author_facet | Yuhua Zhu Dan Bing Dayong Wang Lidong Zhao Zifang Yin Qiujing Zhang Jing Guan Qiuju Wang |
| author_sort | Yuhua Zhu |
| collection | DOAJ |
| description | Background: Sudden sensorineural hearing loss (SSHL) refers to the sudden occurrence of unexplained sensorineural hearing loss. The present study showed that different systemic diseases had different influence on the occurrence and hearing outcome of SSHL. Thyroid hormone is one of the important factors for the development of fetal ear and auditory function. However, the distribution of thyroid dysfunction in SSHL patients and the effect of thyroid dysfunction on the occurrence and hearing outcome of SSHL has not been studied. Methods: In this study, a retrospective analysis had been done in 676 patients with SSHL. We had described the distribution of thyroid function in patients with SSHL in detail, and by the statistical method, analyzed the relationship between the hearing outcome and thyroid dysfunction, respectively. Results: In all patients, 24.41% (165/676) had abnormal thyroid function testing results. The onset age of SSHL in FT3 abnormal group (including low and high group) was younger than that in normal FT3 group. Recovery group had more patients with lower-than-normal T3 level as compared to non-recovery patients. Significant associations between T3 levels and hearing outcome were observed in the subgroup with longer time elapse between symptom onset and treatment (≥14 d). Conclusion: The incidence of thyroid dysfunction in SSHL is significantly higher than in the general population. There was obvious relationship between T3 and FT3 item of thyroid dysfunction and the onset time and hearing outcome of SSHL, which indicated that T3 or FT3 indicator may be one of the affecting factors for the SSHL. Early screening and diagnosis of thyroid dysfunction, especial T3 level, may help to evaluate the prognosis in SSHL patients. |
| first_indexed | 2024-12-12T13:31:10Z |
| format | Article |
| id | doaj.art-d44c6d522e884d3da6279bd62b70d49d |
| institution | Directory Open Access Journal |
| issn | 2095-8811 |
| language | English |
| last_indexed | 2024-12-12T13:31:10Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | World Journal of Otorhinolaryngology-Head and Neck Surgery |
| spelling | doaj.art-d44c6d522e884d3da6279bd62b70d49d2022-12-22T00:23:04ZengWileyWorld Journal of Otorhinolaryngology-Head and Neck Surgery2095-88112021-01-017118Analysis of thyroid dysfunction in patients with sudden sensorineural hearing lossYuhua Zhu0Dan Bing1Dayong Wang2Lidong Zhao3Zifang Yin4Qiujing Zhang5Jing Guan6Qiuju Wang7Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, 100853, China; Department of Otolaryngology Head and Neck Surgery, Hainan Hospital of Chinese PLA General Hospital, Hainan, 572013, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, ChinaDepartment of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, 100853, ChinaDepartment of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, 100853, ChinaDepartment of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, 100853, ChinaDepartment of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, 100853, ChinaDepartment of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, 100853, ChinaDepartment of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, 100853, China; Corresponding author.Background: Sudden sensorineural hearing loss (SSHL) refers to the sudden occurrence of unexplained sensorineural hearing loss. The present study showed that different systemic diseases had different influence on the occurrence and hearing outcome of SSHL. Thyroid hormone is one of the important factors for the development of fetal ear and auditory function. However, the distribution of thyroid dysfunction in SSHL patients and the effect of thyroid dysfunction on the occurrence and hearing outcome of SSHL has not been studied. Methods: In this study, a retrospective analysis had been done in 676 patients with SSHL. We had described the distribution of thyroid function in patients with SSHL in detail, and by the statistical method, analyzed the relationship between the hearing outcome and thyroid dysfunction, respectively. Results: In all patients, 24.41% (165/676) had abnormal thyroid function testing results. The onset age of SSHL in FT3 abnormal group (including low and high group) was younger than that in normal FT3 group. Recovery group had more patients with lower-than-normal T3 level as compared to non-recovery patients. Significant associations between T3 levels and hearing outcome were observed in the subgroup with longer time elapse between symptom onset and treatment (≥14 d). Conclusion: The incidence of thyroid dysfunction in SSHL is significantly higher than in the general population. There was obvious relationship between T3 and FT3 item of thyroid dysfunction and the onset time and hearing outcome of SSHL, which indicated that T3 or FT3 indicator may be one of the affecting factors for the SSHL. Early screening and diagnosis of thyroid dysfunction, especial T3 level, may help to evaluate the prognosis in SSHL patients.http://www.sciencedirect.com/science/article/pii/S2095881119301003Thyroid dysfunctionSudden sensorineural hearing lossHearing outcome |
| spellingShingle | Yuhua Zhu Dan Bing Dayong Wang Lidong Zhao Zifang Yin Qiujing Zhang Jing Guan Qiuju Wang Analysis of thyroid dysfunction in patients with sudden sensorineural hearing loss World Journal of Otorhinolaryngology-Head and Neck Surgery Thyroid dysfunction Sudden sensorineural hearing loss Hearing outcome |
| title | Analysis of thyroid dysfunction in patients with sudden sensorineural hearing loss |
| title_full | Analysis of thyroid dysfunction in patients with sudden sensorineural hearing loss |
| title_fullStr | Analysis of thyroid dysfunction in patients with sudden sensorineural hearing loss |
| title_full_unstemmed | Analysis of thyroid dysfunction in patients with sudden sensorineural hearing loss |
| title_short | Analysis of thyroid dysfunction in patients with sudden sensorineural hearing loss |
| title_sort | analysis of thyroid dysfunction in patients with sudden sensorineural hearing loss |
| topic | Thyroid dysfunction Sudden sensorineural hearing loss Hearing outcome |
| url | http://www.sciencedirect.com/science/article/pii/S2095881119301003 |
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