Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis
Homeostasis in adult tissues relies on the replication dynamics of stem cells, their progenitors and the spatial balance between them. This spatial and kinetic coordination is crucial to the successful maintenance of tissue size and its replenishment with new cells. However, our understanding of the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2021-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/56404 |
| _version_ | 1811200004479516672 |
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| author | Lior Strinkovsky Evgeny Havkin Ruby Shalom-Feuerstein Yonatan Savir |
| author_facet | Lior Strinkovsky Evgeny Havkin Ruby Shalom-Feuerstein Yonatan Savir |
| author_sort | Lior Strinkovsky |
| collection | DOAJ |
| description | Homeostasis in adult tissues relies on the replication dynamics of stem cells, their progenitors and the spatial balance between them. This spatial and kinetic coordination is crucial to the successful maintenance of tissue size and its replenishment with new cells. However, our understanding of the role of cellular replicative lifespan and spatial correlation between cells in shaping tissue integrity is still lacking. We developed a mathematical model for the stochastic spatial dynamics that underlie the rejuvenation of corneal epithelium. Our model takes into account different spatial correlations between cell replication and cell removal. We derive the tradeoffs between replicative lifespan, spatial correlation length, and tissue rejuvenation dynamics. We determine the conditions that allow homeostasis and are consistent with biological timescales, pattern formation, and mutants phenotypes. Our results can be extended to any cellular system in which spatial homeostasis is maintained through cell replication. |
| first_indexed | 2024-04-12T01:57:31Z |
| format | Article |
| id | doaj.art-d44d0c361df94554a9cfc6a03fece194 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:57:31Z |
| publishDate | 2021-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d44d0c361df94554a9cfc6a03fece1942022-12-22T03:52:46ZengeLife Sciences Publications LtdeLife2050-084X2021-01-011010.7554/eLife.56404Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasisLior Strinkovsky0https://orcid.org/0000-0002-0301-3515Evgeny Havkin1Ruby Shalom-Feuerstein2Yonatan Savir3https://orcid.org/0000-0002-5345-8491Department of Physiology, Biophysics and System Biology, Faculty of Medicine, Technion, Haifa, IsraelDepartment of Physiology, Biophysics and System Biology, Faculty of Medicine, Technion, Haifa, IsraelDepartment of Genetics & Developmental Biology, Faculty of Medicine, Technion, Haifa, Israel; The Rappaport Family Institute for Research in the Medical Sciences, Technion, Haifa, IsraelDepartment of Physiology, Biophysics and System Biology, Faculty of Medicine, Technion, Haifa, Israel; The Rappaport Family Institute for Research in the Medical Sciences, Technion, Haifa, IsraelHomeostasis in adult tissues relies on the replication dynamics of stem cells, their progenitors and the spatial balance between them. This spatial and kinetic coordination is crucial to the successful maintenance of tissue size and its replenishment with new cells. However, our understanding of the role of cellular replicative lifespan and spatial correlation between cells in shaping tissue integrity is still lacking. We developed a mathematical model for the stochastic spatial dynamics that underlie the rejuvenation of corneal epithelium. Our model takes into account different spatial correlations between cell replication and cell removal. We derive the tradeoffs between replicative lifespan, spatial correlation length, and tissue rejuvenation dynamics. We determine the conditions that allow homeostasis and are consistent with biological timescales, pattern formation, and mutants phenotypes. Our results can be extended to any cellular system in which spatial homeostasis is maintained through cell replication.https://elifesciences.org/articles/56404adult stem cellsreplicative lifespanmathematical modelingstochastic dynamicstissue homeostasis |
| spellingShingle | Lior Strinkovsky Evgeny Havkin Ruby Shalom-Feuerstein Yonatan Savir Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis eLife adult stem cells replicative lifespan mathematical modeling stochastic dynamics tissue homeostasis |
| title | Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis |
| title_full | Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis |
| title_fullStr | Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis |
| title_full_unstemmed | Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis |
| title_short | Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis |
| title_sort | spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis |
| topic | adult stem cells replicative lifespan mathematical modeling stochastic dynamics tissue homeostasis |
| url | https://elifesciences.org/articles/56404 |
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