Effect of occupational exposure to lead on serum levels of lipid profile and liver enzymes: An occupational cohort study
The present study was performed to know the effects of chronic lead exposure on serum lipids, lipoproteins, and liver enzymes in a cohort study among of lead mine workers. We followed of 200 Iranian workers for 3- years (2018–2020), 100 of them with known occupational exposure to lead thorough their...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750022000270 |
| _version_ | 1811202001444274176 |
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| author | Ali Firoozichahak Samira Rahimnejad Abdolrasoul Rahmani Ali Parvizimehr Abbas Aghaei Razzagh Rahimpoor |
| author_facet | Ali Firoozichahak Samira Rahimnejad Abdolrasoul Rahmani Ali Parvizimehr Abbas Aghaei Razzagh Rahimpoor |
| author_sort | Ali Firoozichahak |
| collection | DOAJ |
| description | The present study was performed to know the effects of chronic lead exposure on serum lipids, lipoproteins, and liver enzymes in a cohort study among of lead mine workers. We followed of 200 Iranian workers for 3- years (2018–2020), 100 of them with known occupational exposure to lead thorough their work in lead mine while the others 100 were with no such exposure. Blood lead level (BLL), serum lipids, lipoproteins, and liver enzymes of the exposure group for 3- years were measured and compared with those attained in the non-exposed workers. The BLL levels of the lead-mine workers were higher than with recommended level and the non-exposed group (24.15 and 6.35 µg/dL, respectively). The findings indicated a positive and significant relationship between BLL and lactate dehydrogenase, aspartate transaminase, alkaline phosphatase, alanine transaminase, and bilirubin levels (P < 0.01). Also while we found a negative and significant correlation between BLL and triglyceride, total protein, albumin, and globulin levels (P < 0.01). This report depicted that chronic lead exposure is a risk factor for hematological, liver, and cardiovascular diseases. Despite the fact that the level of liver function parameters was in the normal range, the results of 3- years follow-up show a significant relationship between BLL and alteration of biochemical parameters levels. |
| first_indexed | 2024-04-12T02:31:25Z |
| format | Article |
| id | doaj.art-d44d6cbabe6646bbabb45534cb059f3d |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-04-12T02:31:25Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-d44d6cbabe6646bbabb45534cb059f3d2022-12-22T03:51:45ZengElsevierToxicology Reports2214-75002022-01-019269275Effect of occupational exposure to lead on serum levels of lipid profile and liver enzymes: An occupational cohort studyAli Firoozichahak0Samira Rahimnejad1Abdolrasoul Rahmani2Ali Parvizimehr3Abbas Aghaei4Razzagh Rahimpoor5Department of Occupational Health Engineering, Faculty of Health, Research Center for Health Sciences Infectious Diseases Research Center, Gonabad University of Medical Sciences, Gonabad, IranDepartment of Occupational Health Engineering, Faculty of Health, Kurdistan University of Medical Sciences, Sanandaj, IranDepartment of Occupational Health Engineering, Research Center for Health Sciences, School of Health, Larestan University of Medical Sciences, Larestan, IranDepartment of Environmental Health Engineering, Research Center for Health, Safety and Environment, School of Health, Larestan University of Medical Sciences, Larestan, IranCancer and Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, IranDepartment of Occupational Health Engineering, Research Center for Health Sciences, School of Health, Larestan University of Medical Sciences, Larestan, Iran; Correspondence to: Larestan University of Medical Sciences, Faculty of Evaz Health, P.O. box: 125, 74671 Larestan, Iran.The present study was performed to know the effects of chronic lead exposure on serum lipids, lipoproteins, and liver enzymes in a cohort study among of lead mine workers. We followed of 200 Iranian workers for 3- years (2018–2020), 100 of them with known occupational exposure to lead thorough their work in lead mine while the others 100 were with no such exposure. Blood lead level (BLL), serum lipids, lipoproteins, and liver enzymes of the exposure group for 3- years were measured and compared with those attained in the non-exposed workers. The BLL levels of the lead-mine workers were higher than with recommended level and the non-exposed group (24.15 and 6.35 µg/dL, respectively). The findings indicated a positive and significant relationship between BLL and lactate dehydrogenase, aspartate transaminase, alkaline phosphatase, alanine transaminase, and bilirubin levels (P < 0.01). Also while we found a negative and significant correlation between BLL and triglyceride, total protein, albumin, and globulin levels (P < 0.01). This report depicted that chronic lead exposure is a risk factor for hematological, liver, and cardiovascular diseases. Despite the fact that the level of liver function parameters was in the normal range, the results of 3- years follow-up show a significant relationship between BLL and alteration of biochemical parameters levels.http://www.sciencedirect.com/science/article/pii/S2214750022000270Lead Poisoning, Occupational Exposure, Liver Function TestBiomarkersMines |
| spellingShingle | Ali Firoozichahak Samira Rahimnejad Abdolrasoul Rahmani Ali Parvizimehr Abbas Aghaei Razzagh Rahimpoor Effect of occupational exposure to lead on serum levels of lipid profile and liver enzymes: An occupational cohort study Toxicology Reports Lead Poisoning, Occupational Exposure, Liver Function Test Biomarkers Mines |
| title | Effect of occupational exposure to lead on serum levels of lipid profile and liver enzymes: An occupational cohort study |
| title_full | Effect of occupational exposure to lead on serum levels of lipid profile and liver enzymes: An occupational cohort study |
| title_fullStr | Effect of occupational exposure to lead on serum levels of lipid profile and liver enzymes: An occupational cohort study |
| title_full_unstemmed | Effect of occupational exposure to lead on serum levels of lipid profile and liver enzymes: An occupational cohort study |
| title_short | Effect of occupational exposure to lead on serum levels of lipid profile and liver enzymes: An occupational cohort study |
| title_sort | effect of occupational exposure to lead on serum levels of lipid profile and liver enzymes an occupational cohort study |
| topic | Lead Poisoning, Occupational Exposure, Liver Function Test Biomarkers Mines |
| url | http://www.sciencedirect.com/science/article/pii/S2214750022000270 |
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