Impact of MRI on target volume definition in head and neck cancer patients
Abstract Background Target volume definition for curative radiochemotherapy in head and neck cancer is crucial since the predominant recurrence pattern is local. Additional diagnostic imaging like MRI is increasingly used, yet it is usually hampered by different patient positioning compared to radio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13014-023-02326-0 |
| _version_ | 1797451919780741120 |
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| author | Kerstin Clasen Marcel Nachbar Sergios Gatidis Daniel Zips Daniela Thorwarth Stefan Welz |
| author_facet | Kerstin Clasen Marcel Nachbar Sergios Gatidis Daniel Zips Daniela Thorwarth Stefan Welz |
| author_sort | Kerstin Clasen |
| collection | DOAJ |
| description | Abstract Background Target volume definition for curative radiochemotherapy in head and neck cancer is crucial since the predominant recurrence pattern is local. Additional diagnostic imaging like MRI is increasingly used, yet it is usually hampered by different patient positioning compared to radiotherapy. In this study, we investigated the impact of diagnostic MRI in treatment position for target volume delineation. Methods We prospectively analyzed patients who were suitable and agreed to undergo an MRI in treatment position with immobilization devices prior to radiotherapy planning from 2017 to 2019. Target volume delineation for the primary tumor was first performed using all available information except for the MRI and subsequently with additional consideration of the co-registered MRI. The derived volumes were compared by subjective visual judgment and by quantitative mathematical methods. Results Sixteen patients were included and underwent the planning CT, MRI and subsequent definitive radiochemotherapy. In 69% of the patients, there were visually relevant changes to the gross tumor volume (GTV) by use of the MRI. In 44%, the GTV_MRI would not have been covered completely by the planning target volume (PTV) of the CT-only contour. Yet, median Hausdorff und DSI values did not reflect these differences. The 3-year local control rate was 94%. Conclusions Adding a diagnostic MRI in RT treatment position is feasible and results in relevant changes in target volumes in the majority of patients. |
| first_indexed | 2024-03-09T15:01:25Z |
| format | Article |
| id | doaj.art-d44e825614404160b57bc1c717614552 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-03-09T15:01:25Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-d44e825614404160b57bc1c7176145522023-11-26T13:54:10ZengBMCRadiation Oncology1748-717X2023-09-011811710.1186/s13014-023-02326-0Impact of MRI on target volume definition in head and neck cancer patientsKerstin Clasen0Marcel Nachbar1Sergios Gatidis2Daniel Zips3Daniela Thorwarth4Stefan Welz5Department of Radiation Oncology, University Hospital Tübingen, University of TübingenSection for Biomedical Physics, Department of Radiation Oncology, University Hospital Tübingen, University of TübingenDepartment of Radiology, University Hospital Tübingen, University of TübingenDepartment of Radiation Oncology, University Hospital Tübingen, University of TübingenSection for Biomedical Physics, Department of Radiation Oncology, University Hospital Tübingen, University of TübingenDepartment of Radiation Oncology, University Hospital Tübingen, University of TübingenAbstract Background Target volume definition for curative radiochemotherapy in head and neck cancer is crucial since the predominant recurrence pattern is local. Additional diagnostic imaging like MRI is increasingly used, yet it is usually hampered by different patient positioning compared to radiotherapy. In this study, we investigated the impact of diagnostic MRI in treatment position for target volume delineation. Methods We prospectively analyzed patients who were suitable and agreed to undergo an MRI in treatment position with immobilization devices prior to radiotherapy planning from 2017 to 2019. Target volume delineation for the primary tumor was first performed using all available information except for the MRI and subsequently with additional consideration of the co-registered MRI. The derived volumes were compared by subjective visual judgment and by quantitative mathematical methods. Results Sixteen patients were included and underwent the planning CT, MRI and subsequent definitive radiochemotherapy. In 69% of the patients, there were visually relevant changes to the gross tumor volume (GTV) by use of the MRI. In 44%, the GTV_MRI would not have been covered completely by the planning target volume (PTV) of the CT-only contour. Yet, median Hausdorff und DSI values did not reflect these differences. The 3-year local control rate was 94%. Conclusions Adding a diagnostic MRI in RT treatment position is feasible and results in relevant changes in target volumes in the majority of patients.https://doi.org/10.1186/s13014-023-02326-0RadiotherapyIMRTMRI imagingLocal controlTarget volume delineationHNSCC |
| spellingShingle | Kerstin Clasen Marcel Nachbar Sergios Gatidis Daniel Zips Daniela Thorwarth Stefan Welz Impact of MRI on target volume definition in head and neck cancer patients Radiation Oncology Radiotherapy IMRT MRI imaging Local control Target volume delineation HNSCC |
| title | Impact of MRI on target volume definition in head and neck cancer patients |
| title_full | Impact of MRI on target volume definition in head and neck cancer patients |
| title_fullStr | Impact of MRI on target volume definition in head and neck cancer patients |
| title_full_unstemmed | Impact of MRI on target volume definition in head and neck cancer patients |
| title_short | Impact of MRI on target volume definition in head and neck cancer patients |
| title_sort | impact of mri on target volume definition in head and neck cancer patients |
| topic | Radiotherapy IMRT MRI imaging Local control Target volume delineation HNSCC |
| url | https://doi.org/10.1186/s13014-023-02326-0 |
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