Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in Rats
After inferior caval vein embolization therapy, post-embolization syndrome (sodium laurate 10 mg/kg, 0.1 mL into rat inferior caval vein, assessment at 15, 30, 60 min, prime lung lesions, thromboemboli occluding lung vessels), as a severe occlusion/occlusion-like syndrome, might be resolved as a who...
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MDPI AG
2023-10-01
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| author | Ivan Maria Smoday Ivan Krezic Luka Kalogjera Vlasta Vukovic Helena Zizek Marija Skoro Katarina Kasnik Kovac Hrvoje Vranes Ivan Barisic Suncana Sikiric Sanja Strbe Marijan Tepes Katarina Oroz Slavica Zubcic Mirjana Stupnisek Lidija Beketic Oreskovic Ivana Kavelj Luka Novosel Matea Prenc Sanja Barsic Ostojic Ivan Dobric Marko Sever Alenka Boban Blagaic Anita Skrtic Mario Staresinic Ivica Sjekavica Sven Seiwerth Predrag Sikiric |
| author_facet | Ivan Maria Smoday Ivan Krezic Luka Kalogjera Vlasta Vukovic Helena Zizek Marija Skoro Katarina Kasnik Kovac Hrvoje Vranes Ivan Barisic Suncana Sikiric Sanja Strbe Marijan Tepes Katarina Oroz Slavica Zubcic Mirjana Stupnisek Lidija Beketic Oreskovic Ivana Kavelj Luka Novosel Matea Prenc Sanja Barsic Ostojic Ivan Dobric Marko Sever Alenka Boban Blagaic Anita Skrtic Mario Staresinic Ivica Sjekavica Sven Seiwerth Predrag Sikiric |
| author_sort | Ivan Maria Smoday |
| collection | DOAJ |
| description | After inferior caval vein embolization therapy, post-embolization syndrome (sodium laurate 10 mg/kg, 0.1 mL into rat inferior caval vein, assessment at 15, 30, 60 min, prime lung lesions, thromboemboli occluding lung vessels), as a severe occlusion/occlusion-like syndrome, might be resolved as a whole by stable gastric pentadecapeptide BPC 157 therapy. At 5 min after laurate injection, stable gastric pentadecapeptide BPC 157 was implemented as therapy (10 µg/kg, 10 ng/kg intraperitoneally or intragastrically). As before, confronted with the occlusion of major vessel(s) or similar noxious procedures, such as rapidly acting Virchow triad circumstances, the particular effect of the therapy (i.e., collateral pathways activation, “bypassing vascular key”, i.e., direct blood flow delivery via activation of azygos vein) assisted in the recovery of the vessel/s and counteracted multiorgan failure due to occlusion/occlusion-like syndrome as a whole in the laurate-injected rats. Along with prime lung lesions and thromboemboli occluding lung vessels, post-embolization syndrome rapidly occurred peripherally and centrally as a shared multiorgan and vessel failure, brain, heart, lung, liver, kidney, and gastrointestinal tract lesions, venous hypertension (intracranial (superior sagittal sinus), portal, and caval), aortal hypotension, progressing thrombosis in veins and arteries and stasis, congested and/or failed major veins, and severe ECG disturbances. Whatever the cause, these were all counteracted, eliminated, or attenuated by the application of BPC 157 therapy. As recovery with BPC 157 therapy commonly and rapidly occurred, reversing the collapsed azygos vein to the rescuing collateral pathway might initiate rapid direct blood delivery and start blood flow reorganization. In conclusion, we suggest BPC 157 therapy to resolve further vascular and embolization injuries. |
| first_indexed | 2024-03-10T20:59:05Z |
| format | Article |
| id | doaj.art-d44efe72d9b24351a667a1fb9820026b |
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| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T20:59:05Z |
| publishDate | 2023-10-01 |
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| series | Pharmaceuticals |
| spelling | doaj.art-d44efe72d9b24351a667a1fb9820026b2023-11-19T17:43:30ZengMDPI AGPharmaceuticals1424-82472023-10-011610150710.3390/ph16101507Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in RatsIvan Maria Smoday0Ivan Krezic1Luka Kalogjera2Vlasta Vukovic3Helena Zizek4Marija Skoro5Katarina Kasnik Kovac6Hrvoje Vranes7Ivan Barisic8Suncana Sikiric9Sanja Strbe10Marijan Tepes11Katarina Oroz12Slavica Zubcic13Mirjana Stupnisek14Lidija Beketic Oreskovic15Ivana Kavelj16Luka Novosel17Matea Prenc18Sanja Barsic Ostojic19Ivan Dobric20Marko Sever21Alenka Boban Blagaic22Anita Skrtic23Mario Staresinic24Ivica Sjekavica25Sven Seiwerth26Predrag Sikiric27Department of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Diagnostic and Interventional Radiology, University Hospital Centre, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Diagnostic and Interventional Radiology, University Hospital Centre, 10000 Zagreb, CroatiaDepartment of Diagnostic and Interventional Radiology, University Hospital Centre, 10000 Zagreb, CroatiaDepartment of Diagnostic and Interventional Radiology, University Hospital Centre, 10000 Zagreb, CroatiaDepartment of Diagnostic and Interventional Radiology, University Hospital Centre, 10000 Zagreb, CroatiaDepartment of Surgery, School of Medicine, University of Zagreb,10000 Zagreb, CroatiaDepartment of Surgery, School of Medicine, University of Zagreb,10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Surgery, School of Medicine, University of Zagreb,10000 Zagreb, CroatiaDepartment of Diagnostic and Interventional Radiology, University Hospital Centre, 10000 Zagreb, CroatiaDepartment of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, CroatiaAfter inferior caval vein embolization therapy, post-embolization syndrome (sodium laurate 10 mg/kg, 0.1 mL into rat inferior caval vein, assessment at 15, 30, 60 min, prime lung lesions, thromboemboli occluding lung vessels), as a severe occlusion/occlusion-like syndrome, might be resolved as a whole by stable gastric pentadecapeptide BPC 157 therapy. At 5 min after laurate injection, stable gastric pentadecapeptide BPC 157 was implemented as therapy (10 µg/kg, 10 ng/kg intraperitoneally or intragastrically). As before, confronted with the occlusion of major vessel(s) or similar noxious procedures, such as rapidly acting Virchow triad circumstances, the particular effect of the therapy (i.e., collateral pathways activation, “bypassing vascular key”, i.e., direct blood flow delivery via activation of azygos vein) assisted in the recovery of the vessel/s and counteracted multiorgan failure due to occlusion/occlusion-like syndrome as a whole in the laurate-injected rats. Along with prime lung lesions and thromboemboli occluding lung vessels, post-embolization syndrome rapidly occurred peripherally and centrally as a shared multiorgan and vessel failure, brain, heart, lung, liver, kidney, and gastrointestinal tract lesions, venous hypertension (intracranial (superior sagittal sinus), portal, and caval), aortal hypotension, progressing thrombosis in veins and arteries and stasis, congested and/or failed major veins, and severe ECG disturbances. Whatever the cause, these were all counteracted, eliminated, or attenuated by the application of BPC 157 therapy. As recovery with BPC 157 therapy commonly and rapidly occurred, reversing the collapsed azygos vein to the rescuing collateral pathway might initiate rapid direct blood delivery and start blood flow reorganization. In conclusion, we suggest BPC 157 therapy to resolve further vascular and embolization injuries.https://www.mdpi.com/1424-8247/16/10/1507post-embolization syndromegeneral occlusion/occlusion-like syndromestable gastric pentadecapeptide BPC 157therapyrats |
| spellingShingle | Ivan Maria Smoday Ivan Krezic Luka Kalogjera Vlasta Vukovic Helena Zizek Marija Skoro Katarina Kasnik Kovac Hrvoje Vranes Ivan Barisic Suncana Sikiric Sanja Strbe Marijan Tepes Katarina Oroz Slavica Zubcic Mirjana Stupnisek Lidija Beketic Oreskovic Ivana Kavelj Luka Novosel Matea Prenc Sanja Barsic Ostojic Ivan Dobric Marko Sever Alenka Boban Blagaic Anita Skrtic Mario Staresinic Ivica Sjekavica Sven Seiwerth Predrag Sikiric Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in Rats Pharmaceuticals post-embolization syndrome general occlusion/occlusion-like syndrome stable gastric pentadecapeptide BPC 157 therapy rats |
| title | Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in Rats |
| title_full | Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in Rats |
| title_fullStr | Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in Rats |
| title_full_unstemmed | Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in Rats |
| title_short | Pentadecapeptide BPC 157 as Therapy for Inferior Caval Vein Embolization: Recovery of Sodium Laurate-Post-Embolization Syndrome in Rats |
| title_sort | pentadecapeptide bpc 157 as therapy for inferior caval vein embolization recovery of sodium laurate post embolization syndrome in rats |
| topic | post-embolization syndrome general occlusion/occlusion-like syndrome stable gastric pentadecapeptide BPC 157 therapy rats |
| url | https://www.mdpi.com/1424-8247/16/10/1507 |
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