Gestational Dysfunction-Driven Diets and Probiotic Supplementation Correlate with the Profile of Allergen-Specific Antibodies in the Serum of Allergy Sufferers
Background: Maternal diet has significant effects on development of childhood atopic disease and hypersensitivity development. However, the gestational dysfunctions demanding special diets are becoming a widespread phenomenon, their immunological implications can be manifested in the profile of anti...
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MDPI AG
2020-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/8/2381 |
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| author | Anna Maria Ogrodowczyk Magdalena Zakrzewska Ewa Romaszko Barbara Wróblewska |
| author_facet | Anna Maria Ogrodowczyk Magdalena Zakrzewska Ewa Romaszko Barbara Wróblewska |
| author_sort | Anna Maria Ogrodowczyk |
| collection | DOAJ |
| description | Background: Maternal diet has significant effects on development of childhood atopic disease and hypersensitivity development. However, the gestational dysfunctions demanding special diets are becoming a widespread phenomenon, their immunological implications can be manifested in the profile of antibodies in the offspring’s serum. Methods: 153 allergic and 150 healthy individuals were diagnosed for allergy using specific antibody and cytokine immunoassay tests. The medical history of subjects along with mothers’ course of pregnancy was completed by allergologist’s anamnesis. A self-organizing neural network and multivariate analyses to complex data and pick basic interactions were used. Results: Two significant explanatory modules were determined. The first was formed by gestational diabetic and cholestatic diet, infant formula feeding type, probiotic supplementation and its BMI index, moderate IgE, increased IgG levels of antibodies and single or poly-food allergy type (7 clusters). The second was formed by gestational vegan/vegetarian and elimination diet, maternal probiotic supplementation, sex, high IgE total antibodies and food and mixed poly-allergy to aero- and food-origin allergens (19 clusters). Conclusions: Significant associations were observed between special gestational diet intake underlying foetal programming and the mechanisms of childhood allergy. The novelty is the positive association between diabetic and cholestatic diet intake and IgE/IgG-mediated food hypersensitivity. |
| first_indexed | 2024-03-10T17:45:21Z |
| format | Article |
| id | doaj.art-d4503b5d24c54724bd6e79d23ef60869 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T17:45:21Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-d4503b5d24c54724bd6e79d23ef608692023-11-20T09:34:21ZengMDPI AGNutrients2072-66432020-08-01128238110.3390/nu12082381Gestational Dysfunction-Driven Diets and Probiotic Supplementation Correlate with the Profile of Allergen-Specific Antibodies in the Serum of Allergy SufferersAnna Maria Ogrodowczyk0Magdalena Zakrzewska1Ewa Romaszko2Barbara Wróblewska3Department of Immunology and Food Microbiology, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, PolandThe Center for Pulmonary Diseases, Allergy Outpatient Clinic, Jagiellońska 78, 10-357 Olsztyn, PolandNon-Public Health Care Clinic “ATARAX”, 1 Maja 3, 10-117 Olsztyn, PolandDepartment of Immunology and Food Microbiology, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, PolandBackground: Maternal diet has significant effects on development of childhood atopic disease and hypersensitivity development. However, the gestational dysfunctions demanding special diets are becoming a widespread phenomenon, their immunological implications can be manifested in the profile of antibodies in the offspring’s serum. Methods: 153 allergic and 150 healthy individuals were diagnosed for allergy using specific antibody and cytokine immunoassay tests. The medical history of subjects along with mothers’ course of pregnancy was completed by allergologist’s anamnesis. A self-organizing neural network and multivariate analyses to complex data and pick basic interactions were used. Results: Two significant explanatory modules were determined. The first was formed by gestational diabetic and cholestatic diet, infant formula feeding type, probiotic supplementation and its BMI index, moderate IgE, increased IgG levels of antibodies and single or poly-food allergy type (7 clusters). The second was formed by gestational vegan/vegetarian and elimination diet, maternal probiotic supplementation, sex, high IgE total antibodies and food and mixed poly-allergy to aero- and food-origin allergens (19 clusters). Conclusions: Significant associations were observed between special gestational diet intake underlying foetal programming and the mechanisms of childhood allergy. The novelty is the positive association between diabetic and cholestatic diet intake and IgE/IgG-mediated food hypersensitivity.https://www.mdpi.com/2072-6643/12/8/2381gestational dysfunction-driven dietsprobiotics supplementationfoetal programmingallergy prevalencespecific IgE-antibodies profileallergic patterns |
| spellingShingle | Anna Maria Ogrodowczyk Magdalena Zakrzewska Ewa Romaszko Barbara Wróblewska Gestational Dysfunction-Driven Diets and Probiotic Supplementation Correlate with the Profile of Allergen-Specific Antibodies in the Serum of Allergy Sufferers Nutrients gestational dysfunction-driven diets probiotics supplementation foetal programming allergy prevalence specific IgE-antibodies profile allergic patterns |
| title | Gestational Dysfunction-Driven Diets and Probiotic Supplementation Correlate with the Profile of Allergen-Specific Antibodies in the Serum of Allergy Sufferers |
| title_full | Gestational Dysfunction-Driven Diets and Probiotic Supplementation Correlate with the Profile of Allergen-Specific Antibodies in the Serum of Allergy Sufferers |
| title_fullStr | Gestational Dysfunction-Driven Diets and Probiotic Supplementation Correlate with the Profile of Allergen-Specific Antibodies in the Serum of Allergy Sufferers |
| title_full_unstemmed | Gestational Dysfunction-Driven Diets and Probiotic Supplementation Correlate with the Profile of Allergen-Specific Antibodies in the Serum of Allergy Sufferers |
| title_short | Gestational Dysfunction-Driven Diets and Probiotic Supplementation Correlate with the Profile of Allergen-Specific Antibodies in the Serum of Allergy Sufferers |
| title_sort | gestational dysfunction driven diets and probiotic supplementation correlate with the profile of allergen specific antibodies in the serum of allergy sufferers |
| topic | gestational dysfunction-driven diets probiotics supplementation foetal programming allergy prevalence specific IgE-antibodies profile allergic patterns |
| url | https://www.mdpi.com/2072-6643/12/8/2381 |
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