Reliable differentiation of necrosis and active metabolically contours of glioblastoma multiforme using susceptibility-based imaging
Purpose: Gadolinium-enhancing necrosis in glioblastoma multiforme (GBM), as an occasionally occurring false positive in contrast enhancement (CE) imaging, leads to trouble for segmentation of GBM and treatment. Therefore, the investigation of complementary detection way to identify the metabolically...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402404386X |
| _version_ | 1797242982706970624 |
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| author | Anita Ebrahimpour Mehdi Khoobi Nader Riyahi Alam Mahboubeh Masoumbeigi Fatemeh Tirgar Tayyebeh Ebrahimi |
| author_facet | Anita Ebrahimpour Mehdi Khoobi Nader Riyahi Alam Mahboubeh Masoumbeigi Fatemeh Tirgar Tayyebeh Ebrahimi |
| author_sort | Anita Ebrahimpour |
| collection | DOAJ |
| description | Purpose: Gadolinium-enhancing necrosis in glioblastoma multiforme (GBM), as an occasionally occurring false positive in contrast enhancement (CE) imaging, leads to trouble for segmentation of GBM and treatment. Therefore, the investigation of complementary detection way to identify the metabolically active volume of the tumor with high reliability is very worth to be addressed. Here, we reported on a case of GBM with gadolinium-enhancing necrosis in an experimental CE imaging study in mice and evaluated the discrimination of the necrosis and metabolically active parts of the GBM using conventional and state-of-the-art susceptibility-based MRI. Methods: In this study, following 5-aminolevulinic acid (ALA) and iron supplements (FAC, 6 h after ALA, intra-tumoral injection) to animal, T2*-W imaging and quantitative susceptibility mapping (QSM) were performed, and compared with CE imaging. Results: The signal intensity (SI) of the active and necrosis areas of the case in the CE image demonstrated no significant difference while the SI on the T2*-W images and susceptibility value in QSM changed 24 and 150%, respectively. Conclusion: The preclinical case report provides valuable insights into the potential of susceptibility-based MRI using ALA + FAC to apply as a robust discriminator between necrotic and viable tumors. |
| first_indexed | 2024-04-24T18:47:52Z |
| format | Article |
| id | doaj.art-d452387f84df430589ffac385bed5a57 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T18:47:52Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d452387f84df430589ffac385bed5a572024-03-27T04:52:35ZengElsevierHeliyon2405-84402024-04-01107e28355Reliable differentiation of necrosis and active metabolically contours of glioblastoma multiforme using susceptibility-based imagingAnita Ebrahimpour0Mehdi Khoobi1Nader Riyahi Alam2Mahboubeh Masoumbeigi3Fatemeh Tirgar4Tayyebeh Ebrahimi5Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Corresponding author.Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Radiology, Faculty of Para-Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, IranDepartment of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IranPurpose: Gadolinium-enhancing necrosis in glioblastoma multiforme (GBM), as an occasionally occurring false positive in contrast enhancement (CE) imaging, leads to trouble for segmentation of GBM and treatment. Therefore, the investigation of complementary detection way to identify the metabolically active volume of the tumor with high reliability is very worth to be addressed. Here, we reported on a case of GBM with gadolinium-enhancing necrosis in an experimental CE imaging study in mice and evaluated the discrimination of the necrosis and metabolically active parts of the GBM using conventional and state-of-the-art susceptibility-based MRI. Methods: In this study, following 5-aminolevulinic acid (ALA) and iron supplements (FAC, 6 h after ALA, intra-tumoral injection) to animal, T2*-W imaging and quantitative susceptibility mapping (QSM) were performed, and compared with CE imaging. Results: The signal intensity (SI) of the active and necrosis areas of the case in the CE image demonstrated no significant difference while the SI on the T2*-W images and susceptibility value in QSM changed 24 and 150%, respectively. Conclusion: The preclinical case report provides valuable insights into the potential of susceptibility-based MRI using ALA + FAC to apply as a robust discriminator between necrotic and viable tumors.http://www.sciencedirect.com/science/article/pii/S240584402404386XGlioblastoma multiformeGadolinium-enhancing necrosisActive metabolically contours5-Aminolevulinic acidQuantitative susceptibility mapping |
| spellingShingle | Anita Ebrahimpour Mehdi Khoobi Nader Riyahi Alam Mahboubeh Masoumbeigi Fatemeh Tirgar Tayyebeh Ebrahimi Reliable differentiation of necrosis and active metabolically contours of glioblastoma multiforme using susceptibility-based imaging Heliyon Glioblastoma multiforme Gadolinium-enhancing necrosis Active metabolically contours 5-Aminolevulinic acid Quantitative susceptibility mapping |
| title | Reliable differentiation of necrosis and active metabolically contours of glioblastoma multiforme using susceptibility-based imaging |
| title_full | Reliable differentiation of necrosis and active metabolically contours of glioblastoma multiforme using susceptibility-based imaging |
| title_fullStr | Reliable differentiation of necrosis and active metabolically contours of glioblastoma multiforme using susceptibility-based imaging |
| title_full_unstemmed | Reliable differentiation of necrosis and active metabolically contours of glioblastoma multiforme using susceptibility-based imaging |
| title_short | Reliable differentiation of necrosis and active metabolically contours of glioblastoma multiforme using susceptibility-based imaging |
| title_sort | reliable differentiation of necrosis and active metabolically contours of glioblastoma multiforme using susceptibility based imaging |
| topic | Glioblastoma multiforme Gadolinium-enhancing necrosis Active metabolically contours 5-Aminolevulinic acid Quantitative susceptibility mapping |
| url | http://www.sciencedirect.com/science/article/pii/S240584402404386X |
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