Half-Dose Photodynamic Therapy as a Novel Treatment Protocol for Circumscribed Choroidal Hemangioma
We present a case series of four patients with circumscribed choroidal hemangioma (CCH) treated with half-dose PDT, proposing this as a novel treatment protocol. Four patients with CCH were included, and then evaluated using multimodal imaging, including optical coherence tomography (OCT), fluoresce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/11/1748 |
| _version_ | 1797467614179491840 |
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| author | David Pérez-González Michaella Goldstein Matias Iglicki Dinah Zur |
| author_facet | David Pérez-González Michaella Goldstein Matias Iglicki Dinah Zur |
| author_sort | David Pérez-González |
| collection | DOAJ |
| description | We present a case series of four patients with circumscribed choroidal hemangioma (CCH) treated with half-dose PDT, proposing this as a novel treatment protocol. Four patients with CCH were included, and then evaluated using multimodal imaging, including optical coherence tomography (OCT), fluorescein angiography, indocyanine green angiography, fundus autofluorescence, and ultrasound following treatment with half-dose and full-fluence PDT. Following half-dose PDT, all patients showed significant shrinkage of the hemangioma, functional improvement, and decrease of intra- and sub-retinal fluid. All patients remained stable after a single PDT treatment, with a follow-up of up to 60 months. No side effects were shown. This is the first report showing long term efficacy of half-dose PDT treatment in cases with CCH. The outcomes from this pilot study are comparable with results using full dose PDT protocols and it can be considered as a viable treatment option for CCH during the ongoing global verteporfin shortage. |
| first_indexed | 2024-03-09T18:56:10Z |
| format | Article |
| id | doaj.art-d454fff97d8b45df8435ad01da265ef1 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T18:56:10Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-d454fff97d8b45df8435ad01da265ef12023-11-24T05:30:19ZengMDPI AGLife2075-17292022-10-011211174810.3390/life12111748Half-Dose Photodynamic Therapy as a Novel Treatment Protocol for Circumscribed Choroidal HemangiomaDavid Pérez-González0Michaella Goldstein1Matias Iglicki2Dinah Zur3Ophthalmology Division, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo 6234906, IsraelOphthalmology Division, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo 6234906, IsraelPrivate Retina Practice, University of Buenos Aires, Buenos Aires 1414, ArgentinaOphthalmology Division, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo 6234906, IsraelWe present a case series of four patients with circumscribed choroidal hemangioma (CCH) treated with half-dose PDT, proposing this as a novel treatment protocol. Four patients with CCH were included, and then evaluated using multimodal imaging, including optical coherence tomography (OCT), fluorescein angiography, indocyanine green angiography, fundus autofluorescence, and ultrasound following treatment with half-dose and full-fluence PDT. Following half-dose PDT, all patients showed significant shrinkage of the hemangioma, functional improvement, and decrease of intra- and sub-retinal fluid. All patients remained stable after a single PDT treatment, with a follow-up of up to 60 months. No side effects were shown. This is the first report showing long term efficacy of half-dose PDT treatment in cases with CCH. The outcomes from this pilot study are comparable with results using full dose PDT protocols and it can be considered as a viable treatment option for CCH during the ongoing global verteporfin shortage.https://www.mdpi.com/2075-1729/12/11/1748choroidal hemangiomachoroidal tumorphotodynamic therapynovel treatment |
| spellingShingle | David Pérez-González Michaella Goldstein Matias Iglicki Dinah Zur Half-Dose Photodynamic Therapy as a Novel Treatment Protocol for Circumscribed Choroidal Hemangioma Life choroidal hemangioma choroidal tumor photodynamic therapy novel treatment |
| title | Half-Dose Photodynamic Therapy as a Novel Treatment Protocol for Circumscribed Choroidal Hemangioma |
| title_full | Half-Dose Photodynamic Therapy as a Novel Treatment Protocol for Circumscribed Choroidal Hemangioma |
| title_fullStr | Half-Dose Photodynamic Therapy as a Novel Treatment Protocol for Circumscribed Choroidal Hemangioma |
| title_full_unstemmed | Half-Dose Photodynamic Therapy as a Novel Treatment Protocol for Circumscribed Choroidal Hemangioma |
| title_short | Half-Dose Photodynamic Therapy as a Novel Treatment Protocol for Circumscribed Choroidal Hemangioma |
| title_sort | half dose photodynamic therapy as a novel treatment protocol for circumscribed choroidal hemangioma |
| topic | choroidal hemangioma choroidal tumor photodynamic therapy novel treatment |
| url | https://www.mdpi.com/2075-1729/12/11/1748 |
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