Risk factors of 30-day and long-term mortality and outcomes in open repair of thoracoabdominal aortic aneurysm
Abstract Background Open repair of thoracoabdominal aortic aneurysm (TAAA) was characterized by significant risk of postoperative mortality and morbidity. The aim of this study was to determine the perioperative predictors of early and long-term mortality in patients undergoing open repair of TAAA....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13019-024-02666-2 |
| _version_ | 1797219624009334784 |
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| author | Sudena Wang Chunrong Wang Yuchen Gao Yu Tian Jia Liu Yuefu Wang |
| author_facet | Sudena Wang Chunrong Wang Yuchen Gao Yu Tian Jia Liu Yuefu Wang |
| author_sort | Sudena Wang |
| collection | DOAJ |
| description | Abstract Background Open repair of thoracoabdominal aortic aneurysm (TAAA) was characterized by significant risk of postoperative mortality and morbidity. The aim of this study was to determine the perioperative predictors of early and long-term mortality in patients undergoing open repair of TAAA. Besides, the postoperative outcomes in patients with open repair of TAAA were described. Methods This is a single-center retrospective study, and 146 patients with open repair of TAAA from January 4, 2011, to November 22, 2018 was involved. Categorical variables were analyzed by the Chi-square test or Fisher’s exact test, and continuous variables were analyzed by the independent sample t-test and the WilCoxon rank-sum test. Multivariate Logistic regression and Cox regression were applied to identify the predictors of 30-day and long-term mortality, respectively. The Kaplan Meier curves were used to illustrate survival with the Log-rank test. Results The 30-day mortality was 9.59% (n = 14). Older than 50 years, the intraoperative volume of red blood cell (RBC) and epinephrine use were independently associated with postoperative 30-day mortality in open repair of TAAA. Long-term mortality was 17.12% (n = 25) (median of 3.5 years (IQR = 2–5 years) of follow-up). Prior open thoracoabdominal aortic aneurysm (TAAA) repair, aortic cross-clamping (ACC) time, intraoperative volume of RBC and use of epinephrine were independently correlated with long-term mortality. Conclusions Identifying perioperative risk factors of early and long-term mortaliy is crucial for surgeons. Intraoperative volume of RBC and use of epinephrine were predictors of both early and long-term mortality. In addition, patients of advanced age, prior open repair of TAAA and prolonged ACC time should be paid more attention. |
| first_indexed | 2024-04-24T12:36:36Z |
| format | Article |
| id | doaj.art-d4568350d07f42b88e41bad55dac16ed |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-04-24T12:36:36Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-d4568350d07f42b88e41bad55dac16ed2024-04-07T11:30:08ZengBMCJournal of Cardiothoracic Surgery1749-80902024-04-011911810.1186/s13019-024-02666-2Risk factors of 30-day and long-term mortality and outcomes in open repair of thoracoabdominal aortic aneurysmSudena Wang0Chunrong Wang1Yuchen Gao2Yu Tian3Jia Liu4Yuefu Wang5Department of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Surgery Intensive Care Unit, Beijing Shijitan Hospital, Capital Medical UniversityAbstract Background Open repair of thoracoabdominal aortic aneurysm (TAAA) was characterized by significant risk of postoperative mortality and morbidity. The aim of this study was to determine the perioperative predictors of early and long-term mortality in patients undergoing open repair of TAAA. Besides, the postoperative outcomes in patients with open repair of TAAA were described. Methods This is a single-center retrospective study, and 146 patients with open repair of TAAA from January 4, 2011, to November 22, 2018 was involved. Categorical variables were analyzed by the Chi-square test or Fisher’s exact test, and continuous variables were analyzed by the independent sample t-test and the WilCoxon rank-sum test. Multivariate Logistic regression and Cox regression were applied to identify the predictors of 30-day and long-term mortality, respectively. The Kaplan Meier curves were used to illustrate survival with the Log-rank test. Results The 30-day mortality was 9.59% (n = 14). Older than 50 years, the intraoperative volume of red blood cell (RBC) and epinephrine use were independently associated with postoperative 30-day mortality in open repair of TAAA. Long-term mortality was 17.12% (n = 25) (median of 3.5 years (IQR = 2–5 years) of follow-up). Prior open thoracoabdominal aortic aneurysm (TAAA) repair, aortic cross-clamping (ACC) time, intraoperative volume of RBC and use of epinephrine were independently correlated with long-term mortality. Conclusions Identifying perioperative risk factors of early and long-term mortaliy is crucial for surgeons. Intraoperative volume of RBC and use of epinephrine were predictors of both early and long-term mortality. In addition, patients of advanced age, prior open repair of TAAA and prolonged ACC time should be paid more attention.https://doi.org/10.1186/s13019-024-02666-2Open repair of descending thoracic and abdominal aortic aneurysmMortalityRisk factorsMortality |
| spellingShingle | Sudena Wang Chunrong Wang Yuchen Gao Yu Tian Jia Liu Yuefu Wang Risk factors of 30-day and long-term mortality and outcomes in open repair of thoracoabdominal aortic aneurysm Journal of Cardiothoracic Surgery Open repair of descending thoracic and abdominal aortic aneurysm Mortality Risk factors Mortality |
| title | Risk factors of 30-day and long-term mortality and outcomes in open repair of thoracoabdominal aortic aneurysm |
| title_full | Risk factors of 30-day and long-term mortality and outcomes in open repair of thoracoabdominal aortic aneurysm |
| title_fullStr | Risk factors of 30-day and long-term mortality and outcomes in open repair of thoracoabdominal aortic aneurysm |
| title_full_unstemmed | Risk factors of 30-day and long-term mortality and outcomes in open repair of thoracoabdominal aortic aneurysm |
| title_short | Risk factors of 30-day and long-term mortality and outcomes in open repair of thoracoabdominal aortic aneurysm |
| title_sort | risk factors of 30 day and long term mortality and outcomes in open repair of thoracoabdominal aortic aneurysm |
| topic | Open repair of descending thoracic and abdominal aortic aneurysm Mortality Risk factors Mortality |
| url | https://doi.org/10.1186/s13019-024-02666-2 |
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