The degree of cortical plasticity correlates with cognitive performance in patients with Multiple Sclerosis
Background: Cortical reorganization and plasticity may compensate for structural damage in Multiple Sclerosis (MS). It is important to establish sensitive methods to measure these compensatory mechanisms, as they may be of prognostic value. Objective: To investigate the association between the degre...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Brain Stimulation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X22000353 |
| _version_ | 1818329780472250368 |
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| author | Carolin Balloff Iris-Katharina Penner Meng Ma Iason Georgiades Lina Scala Nina Troullinakis Jonas Graf David Kremer Orhan Aktas Hans-Peter Hartung Sven Günther Meuth Alfons Schnitzler Stefan Jun Groiss Philipp Albrecht |
| author_facet | Carolin Balloff Iris-Katharina Penner Meng Ma Iason Georgiades Lina Scala Nina Troullinakis Jonas Graf David Kremer Orhan Aktas Hans-Peter Hartung Sven Günther Meuth Alfons Schnitzler Stefan Jun Groiss Philipp Albrecht |
| author_sort | Carolin Balloff |
| collection | DOAJ |
| description | Background: Cortical reorganization and plasticity may compensate for structural damage in Multiple Sclerosis (MS). It is important to establish sensitive methods to measure these compensatory mechanisms, as they may be of prognostic value. Objective: To investigate the association between the degree of cortical plasticity and cognitive performance and to compare plasticity between MS patients and healthy controls (HCs). Methods: The amplitudes of the motor evoked potential (MEP) pre and post quadripulse stimulation (QPS) applied over the contralateral motor cortex served as measure of the degree of cortical plasticity in 63 patients with relapsing-remitting MS (RRMS) and 55 matched HCs. The main outcomes were the correlation coefficients between the difference of MEP amplitudes post and pre QPS and the Symbol Digit Modalities Test (SDMT) and Brief Visuospatial Memory Test-Revised (BVMT-R), and the QPSxgroup interaction in a mixed model predicting the MEP amplitude. Results: SDMT and BVMT-R correlated significantly with QPS-induced cortical plasticity in RRMS patients. Plasticity was significantly reduced in patients with cognitive impairment compared to patients with preserved cognitive function and the degree of plasticity differentiated between both patient groups. Interestingly, the overall RRMS patient cohort did not show reduced plasticity compared to HCs. Conclusions: We provide first evidence that QPS-induced plasticity may inform about the global synaptic plasticity in RRMS which correlates with cognitive performance as well as clinical disability. Larger longitudinal studies on patients with MS are needed to investigate the relevance and prognostic value of this measure for disease progression and recovery. |
| first_indexed | 2024-12-13T12:53:30Z |
| format | Article |
| id | doaj.art-d457609703ad4b9b8103a8a318438e55 |
| institution | Directory Open Access Journal |
| issn | 1935-861X |
| language | English |
| last_indexed | 2024-12-13T12:53:30Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Stimulation |
| spelling | doaj.art-d457609703ad4b9b8103a8a318438e552022-12-21T23:45:15ZengElsevierBrain Stimulation1935-861X2022-03-01152403413The degree of cortical plasticity correlates with cognitive performance in patients with Multiple SclerosisCarolin Balloff0Iris-Katharina Penner1Meng Ma2Iason Georgiades3Lina Scala4Nina Troullinakis5Jonas Graf6David Kremer7Orhan Aktas8Hans-Peter Hartung9Sven Günther Meuth10Alfons Schnitzler11Stefan Jun Groiss12Philipp Albrecht13Department of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, GermanyDepartment of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, Germany; Cogito Center for Applied Neurocognition and Neuropsychological Research, 40225, Düsseldorf, Germany; Department of Neurology, Inselspital, University Hospital Bern, 3010, Bern, SwitzerlandDepartment of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, GermanyDepartment of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, GermanyDepartment of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, GermanyDepartment of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, GermanyDepartment of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, GermanyDepartment of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, GermanyDepartment of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, GermanyDepartment of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, Germany; Brain and Mind Center, University of Sydney, NSW, 2006, Australia; Department of Neurology, Medical University of Vienna, 1090, Vienna, AustriaDepartment of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, GermanyDepartment of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, GermanyDepartment of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, Germany; Corresponding author. Department of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, Germany.Department of Neurology, Medical Faculty, Heinrich-Heine University, 40225, Duesseldorf, GermanyBackground: Cortical reorganization and plasticity may compensate for structural damage in Multiple Sclerosis (MS). It is important to establish sensitive methods to measure these compensatory mechanisms, as they may be of prognostic value. Objective: To investigate the association between the degree of cortical plasticity and cognitive performance and to compare plasticity between MS patients and healthy controls (HCs). Methods: The amplitudes of the motor evoked potential (MEP) pre and post quadripulse stimulation (QPS) applied over the contralateral motor cortex served as measure of the degree of cortical plasticity in 63 patients with relapsing-remitting MS (RRMS) and 55 matched HCs. The main outcomes were the correlation coefficients between the difference of MEP amplitudes post and pre QPS and the Symbol Digit Modalities Test (SDMT) and Brief Visuospatial Memory Test-Revised (BVMT-R), and the QPSxgroup interaction in a mixed model predicting the MEP amplitude. Results: SDMT and BVMT-R correlated significantly with QPS-induced cortical plasticity in RRMS patients. Plasticity was significantly reduced in patients with cognitive impairment compared to patients with preserved cognitive function and the degree of plasticity differentiated between both patient groups. Interestingly, the overall RRMS patient cohort did not show reduced plasticity compared to HCs. Conclusions: We provide first evidence that QPS-induced plasticity may inform about the global synaptic plasticity in RRMS which correlates with cognitive performance as well as clinical disability. Larger longitudinal studies on patients with MS are needed to investigate the relevance and prognostic value of this measure for disease progression and recovery.http://www.sciencedirect.com/science/article/pii/S1935861X22000353Cortical plasticityCognitionMultiple sclerosisRepetitive transcranial magnetic stimulationQuadripulse stimulation |
| spellingShingle | Carolin Balloff Iris-Katharina Penner Meng Ma Iason Georgiades Lina Scala Nina Troullinakis Jonas Graf David Kremer Orhan Aktas Hans-Peter Hartung Sven Günther Meuth Alfons Schnitzler Stefan Jun Groiss Philipp Albrecht The degree of cortical plasticity correlates with cognitive performance in patients with Multiple Sclerosis Brain Stimulation Cortical plasticity Cognition Multiple sclerosis Repetitive transcranial magnetic stimulation Quadripulse stimulation |
| title | The degree of cortical plasticity correlates with cognitive performance in patients with Multiple Sclerosis |
| title_full | The degree of cortical plasticity correlates with cognitive performance in patients with Multiple Sclerosis |
| title_fullStr | The degree of cortical plasticity correlates with cognitive performance in patients with Multiple Sclerosis |
| title_full_unstemmed | The degree of cortical plasticity correlates with cognitive performance in patients with Multiple Sclerosis |
| title_short | The degree of cortical plasticity correlates with cognitive performance in patients with Multiple Sclerosis |
| title_sort | degree of cortical plasticity correlates with cognitive performance in patients with multiple sclerosis |
| topic | Cortical plasticity Cognition Multiple sclerosis Repetitive transcranial magnetic stimulation Quadripulse stimulation |
| url | http://www.sciencedirect.com/science/article/pii/S1935861X22000353 |
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