Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot study
Background: Iliac crest bone graft (ICBG) is considered the gold standard for spine surgical procedures to achieve a successful fusion due to its known osteoinductive and osteoconductive properties. However, complications related to harvesting procedure and donor site morbidity have been largely rep...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1050495/full |
| _version_ | 1811211375335178240 |
|---|---|
| author | Cristiana Griffoni Giuseppe Tedesco Valentina Canella Angelo Nataloni Alberto Zerbi Giovanni Tosini Alessandro Gasbarrini Giovanni Barbanti-Brodano |
| author_facet | Cristiana Griffoni Giuseppe Tedesco Valentina Canella Angelo Nataloni Alberto Zerbi Giovanni Tosini Alessandro Gasbarrini Giovanni Barbanti-Brodano |
| author_sort | Cristiana Griffoni |
| collection | DOAJ |
| description | Background: Iliac crest bone graft (ICBG) is considered the gold standard for spine surgical procedures to achieve a successful fusion due to its known osteoinductive and osteoconductive properties. However, complications related to harvesting procedure and donor site morbidity have been largely reported in the literature, favoring the development of a wide range of alternative products to be used as bone graft extenders or substitutes for spine fusion. Among all, ceramic-based biomaterials have been widely studied and employed in the last years as bone graft substitutes.Methods: We report here the results of a prospective pilot study aimed to evaluating the grade of ossification obtained by the use of an Mg-doped hydroxyapatite (HA) product to achieve postero-lateral fusion in degenerative spine diseases.Results: Results show a successful degree of fusion of about 62% at the 12-month follow-up and an improvement of quality of life and health status following surgery, as evaluated by clinical scores (ODI, VAS, and EQ-5L). No adverse events related to the material were reported.Conclusion: The present pilot study shows the effectiveness and the safety profile of an Mg-doped HA bone graft substitute used to achieve postero-lateral fusion in the treatment of degenerative spine diseases, laying down the basis for further larger clinical investigations. |
| first_indexed | 2024-04-12T05:12:04Z |
| format | Article |
| id | doaj.art-d45799627c9345e98e7caf3546b0e992 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T05:12:04Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-d45799627c9345e98e7caf3546b0e9922022-12-22T03:46:44ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-11-011010.3389/fbioe.2022.10504951050495Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot studyCristiana Griffoni0Giuseppe Tedesco1Valentina Canella2Angelo Nataloni3Alberto Zerbi4Giovanni Tosini5Alessandro Gasbarrini6Giovanni Barbanti-Brodano7Department of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyFinceramica Faenza S.p.A., Faenza, ItalyFinceramica Faenza S.p.A., Faenza, ItalyIstituti Clinici Iseni, Fondazione Iseni y Nervi, Lonate Pozzolo, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyDepartment of Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, Bologna, ItalyBackground: Iliac crest bone graft (ICBG) is considered the gold standard for spine surgical procedures to achieve a successful fusion due to its known osteoinductive and osteoconductive properties. However, complications related to harvesting procedure and donor site morbidity have been largely reported in the literature, favoring the development of a wide range of alternative products to be used as bone graft extenders or substitutes for spine fusion. Among all, ceramic-based biomaterials have been widely studied and employed in the last years as bone graft substitutes.Methods: We report here the results of a prospective pilot study aimed to evaluating the grade of ossification obtained by the use of an Mg-doped hydroxyapatite (HA) product to achieve postero-lateral fusion in degenerative spine diseases.Results: Results show a successful degree of fusion of about 62% at the 12-month follow-up and an improvement of quality of life and health status following surgery, as evaluated by clinical scores (ODI, VAS, and EQ-5L). No adverse events related to the material were reported.Conclusion: The present pilot study shows the effectiveness and the safety profile of an Mg-doped HA bone graft substitute used to achieve postero-lateral fusion in the treatment of degenerative spine diseases, laying down the basis for further larger clinical investigations.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1050495/fulllumbar degenerative disc diseasespinal fusionbone graft substituteBrantigan scorebioceramics |
| spellingShingle | Cristiana Griffoni Giuseppe Tedesco Valentina Canella Angelo Nataloni Alberto Zerbi Giovanni Tosini Alessandro Gasbarrini Giovanni Barbanti-Brodano Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot study Frontiers in Bioengineering and Biotechnology lumbar degenerative disc disease spinal fusion bone graft substitute Brantigan score bioceramics |
| title | Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot study |
| title_full | Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot study |
| title_fullStr | Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot study |
| title_full_unstemmed | Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot study |
| title_short | Ceramic bone graft substitute (Mg-HA) in spinal fusion: A prospective pilot study |
| title_sort | ceramic bone graft substitute mg ha in spinal fusion a prospective pilot study |
| topic | lumbar degenerative disc disease spinal fusion bone graft substitute Brantigan score bioceramics |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1050495/full |
| work_keys_str_mv | AT cristianagriffoni ceramicbonegraftsubstitutemghainspinalfusionaprospectivepilotstudy AT giuseppetedesco ceramicbonegraftsubstitutemghainspinalfusionaprospectivepilotstudy AT valentinacanella ceramicbonegraftsubstitutemghainspinalfusionaprospectivepilotstudy AT angelonataloni ceramicbonegraftsubstitutemghainspinalfusionaprospectivepilotstudy AT albertozerbi ceramicbonegraftsubstitutemghainspinalfusionaprospectivepilotstudy AT giovannitosini ceramicbonegraftsubstitutemghainspinalfusionaprospectivepilotstudy AT alessandrogasbarrini ceramicbonegraftsubstitutemghainspinalfusionaprospectivepilotstudy AT giovannibarbantibrodano ceramicbonegraftsubstitutemghainspinalfusionaprospectivepilotstudy |